Abstract: Systems and methods include causing presentation of a first cluster in association with an event of the first cluster, the first cluster from a first set of clusters of events. Each event includes a time stamp and event data. Based on the presentation of the first cluster, an extraction rule corresponding to the event of the first cluster is received from a user. Similarities in the event data between the events are determined based on the received extraction rule. The events are grouped into a second set of clusters based on the determined similarities. Presentation is caused of a second cluster in association with an event of the second cluster, where the second cluster is from the second set of clusters.

Abstract: Embodiments of the present disclosure provide techniques for performing searches of event records by leveraging reference values in an inverted index. A method of searching comprises accessing a query associated with a first set of event records in a field searchable data store, each event record comprising a time-stamped portion of raw machine data. The method further comprises evaluating the query and generating results for the query by accessing an inverted index, wherein each entry in the inverted index comprises at least one field, a corresponding at least one field value and a reference value that identifies a location in the field searchable data store where an associated event record is stored. The method further comprises performing a search to filter out a second set of event records and retrieving the second set of event records from the field searchable data store using reference values in the inverted index.

Abstract: Disclosed herein are compositions comprising non-naturally occurring zinc finger domains, fusion proteins comprising these zinc finger domains, polynucleotides encoding these proteins, cells expressing these proteins and pharmaceutical compositions comprising these proteins or polynucleotides as well as methods of modifying an Htt gene using these compositions for treating or preventing Huntington's Disease.

Abstract: A data intake and query system executes a search query at a first execution time for querying events having associated time stamps within a first time period characterized by a first start time and a first end time. The first start time is computed based upon a time indicated by reference time information stored prior to execution of the search query. The system determines whether execution of the search query completed successfully based upon a first search result obtained from executing the search query. If the first execution of the search query was not successful, the system computes for a second execution of the search query after the first execution, a second time period using the reference time information. The second execution is configured to query events with associated timestamps that fall within a second time period that includes the first time period and an additional time period.

Abstract: Disclosed herein are variants of a Cas nuclease, polynucleotide encoding the same, compositions thereof, expression vectors, and methods of use thereof, for the generation of transgenic cells, tissues, plants, and animals. The compositions, vectors, and methods of the present invention are also useful in gene therapy and cell therapy techniques.

Abstract: The present disclosure is in the field of diagnostics and therapeutics for Alzheimer's Disease.

Abstract: Disclosed herein are compositions comprising non-naturally occurring zinc finger domains, fusion proteins comprising these zinc finger domains, polynucleotides encoding these proteins, cells expressing these proteins and pharmaceutical compositions comprising these proteins or polynucleotides as well as methods of modifying an Htt gene using these compositions for treating or preventing Huntington's Disease.

Abstract: Systems and methods for rule-based data stream processing by data collection, indexing, and visualization systems. An example method includes: receiving, by the computer system, an input data stream comprising raw machine data; processing the raw machine data by a data processing pipeline that produces transformed machine data, wherein the data processing pipeline comprises an ordered plurality of pipeline stages, wherein a pipeline stage of the ordered plurality of pipeline stages applies a rule of a set of rules to an input of the pipeline stage, wherein the rule specifies an action to be performed on the input of the pipeline stage responsive to evaluating a conditional expression applied to the input of the pipeline stage, wherein the action generates an output of the pipeline stage, and wherein the rule is selected based on a source type associated with the input data stream; and supplying the transformed machine data to a data collection, indexing, and visualization system.

Abstract: Systems and methods include causing presentation of a first cluster in association with an event of the first cluster, the first cluster from a first set of clusters of events. Each event includes a time stamp and event data. Based on the presentation of the first cluster, an extraction rule corresponding to the event of the first cluster is received from a user. Similarities in the event data between the events are determined based on the received extraction rule. The events are grouped into a second set of clusters based on the determined similarities. Presentation is caused of a second cluster in association with an event of the second cluster, where the second cluster is from the second set of clusters.

Abstract: Disclosed is a technique that can be performed by a server computer system. The technique can include executing a machine learning process to generate a machine learning model based on global data collected from one or more electronic devices, wherein the machine learning model is described by model data. The technique can further include encapsulating the model data in a markup language document. The technique can further include sending, over a network, the markup language document to at least one electronic device of the one or more electronic devices to cause the at least one electronic device to update a local device machine learning model.

Abstract: Provided herein are methods and compositions for treating genetic blood cell diseases, e.g. sickle cell disease and thalassemia, by correcting genetic mutation or inserting exogenous globin gene using CRISPR/Cas system.

Abstract: The present disclosure is in the field of diagnostics and therapeutics for Alzheimer's Disease.

Abstract: Embodiments of the present disclosure provide techniques for emitting structured and dynamic fields from an accelerated data model. The method comprises evaluating a query to search a data model, wherein the data model is defined by a set of events and at least one structured field from fields associated with the set of events. Each event comprises a time-stamped portion of raw machine data and is stored in a field searchable data store. A summarization table is associated with the data model and comprises a plurality of entries comprising reference values, wherein a respective summarization table entry comprises: the at least one structured field; a respective field value; and a reference value.

Abstract: The present disclosure is in the field of modulation of Htt gene expression and HTT protein levels.

Abstract: A search request received at a computer of a search support system is processed by analyzing the received search request to identify request parameters and connecting to a system index of the search support system that is referenced in the request parameters. An external result provider (ERP) process is initiated that establishes communication between the search support system and a data source external to the search support system, for a virtual index referenced in the request parameters. Thus, the ERP process provides an interface between the search support system and external data sources, such as by third parties. The ERP process can operate in a streaming mode (providing real-time search results with minimal processing) and/or a reporting mode (providing results with a greater delay and processing extent) and can switch between modes. The search request results are received from the connected system indexes and the referenced virtual indexes.

Abstract: A search request received at a computer of a search support system is processed by analyzing the received search request to identify request parameters and connecting to a system index of the search support system that is referenced in the request parameters. An external result provider (ERP) process is initiated that establishes communication between the search support system and a data source external to the search support system, for a virtual index referenced in the request parameters. Thus, the ERP process provides an interface between the search support system and external data sources, such as by third parties. The ERP process can operate in a streaming mode (providing realtime search results with minimal processing) and/or a reporting mode (providing results with a greater delay and processing extent) and can switch between modes. The search request results are received from the connected system indexes and the referenced virtual indexes.

Abstract: Embodiments of the present disclosure provide techniques for performing searches of event records by leveraging reference values in an inverted index. A method of searching comprises accessing a query associated with a first set of event records in a field searchable data store, each event record comprising a time-stamped portion of raw machine data. The method further comprises evaluating the query and generating results for the query by accessing an inverted index, wherein each entry in the inverted index comprises at least one field, a corresponding at least one field value and a reference value that identifies a location in the field searchable data store where an associated event record is stored. The method further comprises performing a search to filter out a second set of event records and retrieving the second set of event records from the field searchable data store using reference values in the inverted index.

Abstract: A processing device performs a preliminary grouping of data items in a dataset to define one or more clusters and for each cluster, identifies a set of search terms for a search query that would retrieve data items in the cluster upon execution of the search query against the dataset.

Abstract: Systems and methods for rule-based data stream processing by data collection, indexing, and visualization systems. An example method includes: receiving, by the computer system, an input data stream comprising raw machine data; processing the raw machine data by a data processing pipeline that produces transformed machine data, wherein the data processing pipeline comprises an ordered plurality of pipeline stages, wherein a pipeline stage of the ordered plurality of pipeline stages applies a rule of a set of rules to an input of the pipeline stage, wherein the rule specifies an action to be performed on the input of the pipeline stage responsive to evaluating a conditional expression applied to the input of the pipeline stage, wherein the action generates an output of the pipeline stage, and wherein the rule is selected based on a source type associated with the input data stream; and supplying the transformed machine data to a data collection, indexing, and visualization system.

Abstract: The present disclosure is in the field of modulation of Htt gene expression and HTT protein levels.