Abstract: Compounds such as those represented by Formula I can be potent for the Kv7.2/7.3 heteromultimer. These compounds may be used to treat a number of medical conditions, and may be included in dosage forms, pharmaceutical compositions, or medicaments.

Abstract: Techniques discussed herein relate to improved data recovery techniques within cloud computing environments. The disclosed techniques utilize consistency groups that are identified for volumes corresponding to a compute instance. A plurality of resource identifiers uniquely identifying a respective cloud computing resource of the cloud computing environment can be maintained. A cloud computing instance corresponding to a resource identifier may be identified and volume metadata associated with that resource identifier is obtained. The volume metadata identifying at least one of a block volume or boot volume. A consistency group is generated for the identified volume devices for the computing instance and one or more schedules can be generated with which various snapshots of the volume devices of the group are to be subsequently generated.

Abstract: Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

Abstract: Described herein are orally-bioavailable nucleoside analogs and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of coronavirus infections, including SARS-CoV-2 infection.

Abstract: The present disclosure provides broad-spectrum carbapenem derivatives and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such derivatives and/or compositions.

Abstract: Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

Abstract: Techniques discussed herein relate to improved data recovery techniques within cloud computing environments. The disclosed techniques utilize consistency groups that are identified for volumes corresponding to a compute instance. A plurality of resource identifiers uniquely identifying a respective cloud computing resource of the cloud computing environment can be maintained. A cloud computing instance corresponding to a resource identifier may be identified and volume metadata associated with that resource identifier is obtained. The volume metadata identifying at least one of a block volume or boot volume. A consistency group is generated for the identified volume devices for the computing instance and one or more schedules can be generated with which various snapshots of the volume devices of the group are to be subsequently generated.

Abstract: Disclosed herein are NLRP3 inflammasome inhibitors and compositions thereof. Also disclosed herein are methods including administering a therapeutically effective amount of a composition comprising at least one NLRP3 inflammasome inhibitor to a subject in need thereof.

Abstract: Described herein are orally-bioavailable nucleoside analogs and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of coronavirus infections, including SARS-CoV-2 infection.

Abstract: Described herein are orally-bioavailable nucleoside analogs and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of coronavirus infections, including SARS-CoV-2 infection.

Abstract: The present disclosure provides broad-spectrum carbapenem derivatives and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such derivatives and/or compositions.

Abstract: Described herein are hepatitis B capsid assembly modulator compounds of formula (I) and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.

Abstract: Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

Abstract: Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.

Abstract: Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.

Abstract: Image analytics systems, methods, and computer program products to autonomously analyze an image to identify and detect features in the image, such as the horizon, and/or identify and detect objects of interest therein, such as, smoke or possible smoke. The image is captured, for example, by RGB cameras, and depicts a scene to be analyzed. The intelligent image analytic system is configured to provide alerts and/or other information to one or more concerned parties and/or computing systems to take an appropriate response.

Abstract: Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.

Abstract: Described herein are orally-bioavailable nucleoside analogs and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of coronavirus infections, including SARS-CoV-2 infection.

Abstract: Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.

Abstract: Disclosed herein are crystalline forms of ((2-Ethylbutanoyl)oxy)methyl (R)-2-hydroxy-3-propionamido-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylate. Also disclosed herein are methods of treating a bacterial with a crystalline form of ((2-Ethylbutanoyl)oxy)methyl (R)-2-hydroxy-3-propionamido-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylate.