Abstract: A dishwasher appliance includes a tub defining a wash chamber with a diverter assembly at a bottom of the wash chamber, and a wash conduit is positioned in the wash chamber. The wash conduit includes a first supply channel extending between the diverter assembly and a wash conduit outlet, and a second supply channel separate from the first supply channel in the wash conduit. The second supply channel extends between the diverter assembly and an upper spray assembly. The second supply channel includes a first outlet and a second outlet. The second supply channel is configured such that wash fluid is flowable through the second supply channel along a flow path through the second supply channel, and a center of the first outlet of the second supply channel is positioned offset from a center of the flow path through the second supply channel.

Abstract: A dishwasher appliance includes a tub that defines a wash chamber, a third rack assembly slidably positioned in the wash chamber above a second rack assembly, and a third spray assembly positioned within the third rack assembly. The third spray assembly is configured to direct wash fluid at articles located in the third rack assembly. The dishwasher appliance also includes a caddy that is positionable on the third spray assembly. The caddy includes a plurality of mounting projections at a bottom side of the caddy. The mounting projections are configured to engage the third spray assembly in order to locate the caddy on the third spray assembly.

Abstract: A dishwasher appliance includes a tub defining a wash chamber and a wash conduit in the wash chamber. A third rack assembly is slidably positioned in the wash chamber above the second rack assembly with a third spray assembly positioned within the third rack assembly. The third spray assembly is configured to direct wash fluid at articles located in the third rack assembly. The third spray assembly includes a protrusion positioned at a bottom portion of the third spray assembly. The protrusion is attachable to the third rack assembly in order to mount the third spray assembly to the third rack assembly.

Abstract: A dishwasher appliance includes a tub defining a wash chamber and a wash conduit disposed in the wash chamber on a rear wall of the tub. A third rack assembly is slidably positioned in the wash chamber above a second rack assembly with a third spray assembly positioned within the third rack assembly. The third spray assembly is configured to direct wash fluid at articles located in the third rack assembly. The third spray assembly includes an inlet nozzle at one end. The inlet nozzle is offset from the wash conduit outlet in the lateral direction. A portion of the wash conduit extends along the vertical direction between the second and third rack assemblies.

Abstract: This disclosure describes, among other things, techniques for waking a user by changing the user's sleep environment. In one example, a method includes receiving, at a central controller of an air mattress system, at least one user alarm setting, generating, via the central controller, at least one instruction based on the received user alarm setting, and transmitting, from the central controller, the at least one instruction to a first component of the air mattress system to adjust a feature of the first component.

Abstract: A dishwasher appliance includes a tub that defines a wash chamber, and a diverter assembly at a bottom of the wash chamber. The dishwasher appliance also includes a wash conduit in the wash chamber. The wash conduit includes a first supply channel extending between the diverter assembly and a wash conduit outlet, and a second supply channel extending between the diverter assembly and an upper spray assembly. An inlet comprises both a first supply channel inlet and a second supply channel inlet. The first supply channel inlet and the second supply channel inlet are co-planar. The first supply channel inlet and the second supply channel inlet are different shapes.

Abstract: Systems and methods for identifying options for order fulfillment using an API are provided. The system receives, via the API, an order inquiry comprising customer information and item information about an item sold via a merchant website. The order inquiry can be received in response to a customer placing the item in an electronic shopping cart. The item information includes an item identifier and a quantity. The customer information includes a customer address. Using the item information and the customer information, the system identifies warehouse nodes and carriers via which the item can be delivered to the customer. The system confirms inventory of the item in the warehouse nodes. For each warehouse node with sufficient inventory, the system identifies shipping options for the item, including levels of service, cutoff order times, and prices. The system then generates fulfillment options for the item and provides the options to the merchant website.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-8 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: A method may include serially joining different video clips from videos of different historical competitions to form a composite video competition, the different video clips comprising an indeterminate subset of clips drawn from a larger pool of clips, wherein each clip from a historical competition has an associated partial result contribution to a final result of the historical competition further include presenting a result during the composite video competition, the result comprising a linked combination of the partial result contributions from the different video clips.

Abstract: A shaft coupler having first and second spindles adapted to be secured to a first and second output shafts of first and second motors, respectively. A locker ring is assembled to the first spindle, and a locker carrier is assembled to the second spindle. A coil is carried by the locker carrier and switches between an energized state wherein the coil shifts the locker ring to slide into engagement with the second spindle to lock the first and second output shafts together, and a deenergized state wherein a spring biases the locker ring out of engagement with the second spindle to unlock the first and second output shafts from each other. A first set of locking teeth are disengaged from a second set of locking teeth when the coil is deenergized, and are engaged when the coil is energized.

Abstract: A spray system includes a spray device with a housing enclosing an electrostatic power supply that generates an electrostatic charging voltage and a nozzle assembly including a liquid tip that receives a spray liquid and an air stream and emits an atomized spray and an electrode coupled to receive the electrostatic charging voltage and configured to inductively charge the spray. A base unit includes a liquid source that supplies the spray liquid, an air source that supplies the air stream and a power source that supplies power for the electrostatic power supply. A tether couples the spray device to the base unit. The tether includes a liquid supply line coupling the liquid source to the liquid tip, an air supply line coupling the air source to the liquid tip, and a power supply line coupling the power source to the electrostatic power supply.

Abstract: Water-soluble unit dose article containing a laundry detergent composition containing a capsule having a core and a shell.

Abstract: The invention comprises anti-ROR1 chimeric antigen receptor (CAR) T cells (CAR-T cells) natural killer cells (CAR-NK cells), compositions comprising the cells and methods of making and using the same, including methods of treatment of ROR1-expressing tumors.

Abstract: A dishwasher appliance includes a tub defining a wash chamber and a wash conduit in the wash chamber. A third rack assembly is slidably positioned in the wash chamber above a second rack assembly with a third spray assembly positioned within the third rack assembly. The third spray assembly is configured to direct wash fluid at articles located in the third rack assembly. The third spray assembly includes an inlet nozzle that is removably couplable to the wash conduit. The inlet nozzle is offset in the lateral direction from a water jet lane of the third spray assembly and is offset in the vertical direction from a washing plane of the third spray assembly. A flow diverter is disposed at the inlet nozzle. The flow diverter is configured to direct flow in at least two directions within the third spray assembly.

Abstract: A dishwasher appliance includes a tub defining a wash chamber. A first rack assembly is slidably positioned within the wash chamber. A first spray assembly is positioned in the wash chamber and configured to direct wash fluids at the first rack assembly. A second rack assembly is slidably positioned in the wash chamber above the first rack assembly. A second spray assembly is positioned in the wash chamber and configured to direct wash fluids at the second rack assembly. A third rack assembly is slidably positioned in the wash chamber above the second rack assembly. A third spray assembly is positioned over the third rack assembly and configured to direct wash fluid at articles located in the third rack assembly. The third rack assembly includes a wire framework defining the perimeter of the third rack assembly. A wire insert is configured to removably couple to the wire framework. The wire insert includes a wire floor portion.

Abstract: A thermoelectric converter including a thermoelectric generator and a radiation source. The thermoelectric generator includes a hot source, a cold source, n-type material, and p-type material. The radiation source emits ionizing radiation that increases electrical conductivity. Also detailed is a method of using radiation to reach high efficiency with a thermoelectric converter that includes providing a thermoelectric generator and a radiation source, with the thermoelectric generator including a hot source, a cold source, n-type material, and p-type material, and emitting ionizing radiation with the radiation source to increase the electrical conductivity which strips electrons in the n-type material, the p-type material, or both the n-type material and p-type material from their nuclei with the electrons then free to move within the material.

Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

Abstract: The present invention relates to compositions comprising constituents, derivatives or extracts of cannabis. The invention also relates to uses of such compositions and methods of manufacturing them.

Abstract: A child-resistant closure, comprising: an inner shell and an outer shell; wherein the inner shell includes at least one inner lug; wherein the outer shell includes at least one outer lug; wherein the outer lug is movable relative to the inner lug between an engaged position and a disengaged position; wherein in the disengaged position the outer lug is able to rotate past the inner lug when rotated in an opening direction; wherein in the engaged position the outer lug engages the inner lug when rotated in an opening direction to cause opening direction rotation of the inner shell; and an annular band disposed on the inner shell between an inner shell top panel and a shelf; wherein the shelf is disposed axially lower than the top panel; wherein the at least one inner lug extends upwardly from the shelf.

Abstract: The present invention relates to compositions comprising a constituent, derivative or extract of Cannabis in a water soluble matrix. The invention also relates to uses of such compositions and methods of manufacturing them.