Abstract: Provided are chimeric antigen receptors (CARs) having antigenic specificity for B-cell Maturation Antigen (SLAMF7). Also provided are related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs. Methods of treating or preventing cancer in a mammal are also provided.

Abstract: A temperature exposure indicator includes a reservoir of meltable material having a melting point at an activation threshold of the temperature exposure indicator. The temperature exposure indicator also includes a light scattering material having voids and an indicia overlayed by the light scattering material such that the indicia is initially obscured by the light scattering material prior to the meltable material being exposed to a temperature above the activation threshold. The reservoir is in fluid communication with the light scattering material, such that the meltable material, when exposed to a temperature at or above the activation threshold, is configured to melt and flow into the voids of the light scattering material thereby causing the light scattering material to transition from an obscuring form to a non-obscuring form so that the indicia is viewable through the light scattering material.

Abstract: The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a) melanoma antigen family A (MAGE A)-3 in the context of HLA-A1 or b) MAGE-A12 in the context of HLA-Cw7. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are further provided by the invention.

Abstract: The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a) melanoma antigen family A (MAGE A)-3 in the context of HLA-A1 or b) MAGE-A12 in the context of HLA-Cw7. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are further provided by the invention.

Abstract: Techniques for sending encrypted data includes establishing a plurality of different links between a first node and a different second node. The different links are different physical layer links or different virtual private network (VPN) links or some combination. The method also includes encrypting plaintext using a first value for an encryption parameter to produce ciphertext. Further, the method includes sending a first plurality of messages that indicate the ciphertext using at least one link of the plurality of different links. Still further, the method includes sending a different second plurality of messages that indicate the first value for the encryption parameter using at least one different link of the plurality of different links without introducing a random bit error.

Abstract: Provided are chimeric antigen receptors (CARs) having antigenic specificity for B-cell Maturation Antigen (SLAMF7). Also provided are related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs. Methods of treating or preventing cancer in a mammal are also provided.

Abstract: Disclosed are methods of selectively expanding a number of T cells. The methods may comprise: modifying human T cells to express a TCR, wherein the TCR comprises a murine constant region; producing a population of cells comprising a number of human T cells expressing the TCR and a number of human T cells not expressing the TCR; and culturing the population of cells in the presence of (i) irradiated feeder cells, (ii) one or more cytokines, and (iii) an antibody, or an antigen-binding portion thereof, wherein the antibody has antigenic specificity for the murine constant region of the TCR, so as to selectively expand the number of T cells expressing the TCR over the number of T cells not expressing the TCR. Also disclosed are related populations of cells, pharmaceutical compositions, and methods of treating or preventing cancer.

Abstract: Techniques for sending encrypted data includes establishing a plurality of different links between a first node and a different second node. The different links are different physical layer links or different virtual private network (VPN) links or some combination. The method also includes encrypting plaintext using a first value for an encryption parameter to produce ciphertext. Further, the method includes sending a first plurality of messages that indicate the ciphertext using at least one link of the plurality of different links. Still further, the method includes sending a different second plurality of messages that indicate the first value for the encryption parameter using at least one different link of the plurality of different links without introducing a random bit error.

Abstract: Disclosed herein are systems and methods for sending packet replication over sets of bonded diverse packet paths with packet merge and deduplication at the bonded packet paths' egress thereby providing reduced packet loss, latency, and jitter while simultaneously providing high availability. Collectively these sets of bonded packet paths conveying replicated packets compose a virtual overlay network spanning diverse paths, and potentially diverse providers, and diverse network technologies. A control system continuously monitors the reachability and quality of synthetic or both synthetic traffic and bonded packet path traffic across all possible paths as input to the control system that dynamically while taking into account path cost manages the sets of bonded packet paths.

Abstract: An electrical contact terminal includes a base portion for positioning and retaining the electrical contact terminal within a connector housing, an insulation displacement connecting portion extending upwardly from the base portion and comprising a pair of spaced apart arms defining an opening therebetween for receiving and making electrical contact with an electrical conductor, and a contact portion extending downwardly from the base portion and configured to float when the electrical contact terminal is retained and positioned within a connector housing. The contact portion includes a first arm, a second arm, and an arcuate base portion. The first arm extends downwardly and includes a first end attached to the base portion and an opposite second end. The second arm extends downwardly and includes a free first end closer to the base portion and an opposite second end farther from the base portion. The second arm is configured to deflect when making electrical contact with a mating contact pin.

Abstract: Provided herein are methods for manufacturing T cells. In certain embodiments, methods for manufacturing T cells which express a cell surface receptor that recognizes a specific antigenic moiety on the surface of a target cell are provided.

Abstract: The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a) melanoma antigen family A (MAGE A)-3 in the context of HLA-A1 or b) MAGE-A12 in the context of HLA-Cw7. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are further provided by the invention.

Abstract: An electrical connector includes an insulative connector housing including a longitudinal body portion and first and second pairs of opposing end portions. The body portion has a plurality of contact openings extending therein in an insertion direction for supporting a plurality of electrical contact terminals. The first and second pairs of opposing end portions extend from opposing ends of the body portion in the insertion direction. At least one end portion in each pair of opposing end portions includes a ridge extending in the insertion direction for guiding a cover latch along a side surface of the ridge and guiding a strain relief latch along an opposing side surface of the ridge. The ridge has an inclined top surface for resiliently deflecting a cover latch and an inclined side surface for resiliently deflecting a strain relief latch. The ridge has an end portion for latching onto a cover latch and a strain relief latch.

Abstract: An electrical connector includes an insulative connector housing including a longitudinal body portion and first and second pairs of opposing end portions. The body portion has a plurality of contact openings extending therein in an insertion direction for supporting a plurality of electrical contact terminals. The first and second pairs of opposing end portions extend from opposing ends of the body portion in the insertion direction. At least one end portion in each pair of opposing end portions includes a ridge extending in the insertion direction for guiding a cover latch along a side surface of the ridge and guiding a strain relief latch along an opposing side surface of the ridge. The ridge has an inclined top surface for resiliently deflecting a cover latch and an inclined side surface for resiliently deflecting a strain relief latch. The ridge has an end portion for latching onto a cover latch and a strain relief latch.

Abstract: An electrical connector includes an insulative connector housing including a longitudinal body portion and first and second pairs of opposing end portions. The body portion has a plurality of contact openings extending therein in an insertion direction for supporting a plurality of electrical contact terminals. The first and second pairs of opposing end portions extend from opposing ends of the body portion in the insertion direction. At least one end portion in each pair of opposing end portions includes a ridge extending in the insertion direction for guiding a cover latch along a side surface of the ridge and guiding a strain relief latch along an opposing side surface of the ridge. The ridge has an inclined top surface for resiliently deflecting a cover latch and an inclined side surface for resiliently deflecting a strain relief latch. The ridge has an end portion for latching onto a cover latch and a strain relief latch.

Abstract: An electrical contact terminal includes a base portion for positioning and retaining the electrical contact terminal within a connector housing, an insulation displacement connecting portion extending upwardly from the base portion and comprising a pair of spaced apart arms defining an opening therebetween for receiving and making electrical contact with an electrical conductor, and a contact portion extending downwardly from the base portion and configured to float when the electrical contact terminal is retained and positioned within a connector housing. The contact portion includes a first arm, a second arm, and an arcuate base portion. The first arm extends downwardly and includes a first end attached to the base portion and an opposite second end. The second arm extends downwardly and includes a free first end closer to the base portion and an opposite second end farther from the base portion. The second arm is configured to deflect when making electrical contact with a mating contact pin.

Abstract: An electrical contact terminal includes a base portion for positioning and retaining the electrical contact terminal within a connector housing, an insulation displacement connecting portion extending upwardly from the base portion and comprising a pair of spaced apart arms defining an opening therebetween for receiving and making electrical contact with an electrical conductor, and a contact portion extending downwardly from the base portion and configured to float when the electrical contact terminal is retained and positioned within a connector housing. The contact portion includes a first arm, a second arm, and an arcuate base portion. The first arm extends downwardly and includes a first end attached to the base portion and an opposite second end. The second arm extends downwardly and includes a free first end closer to the base portion and an opposite second end farther from the base portion. The second arm is configured to deflect when making electrical contact with a mating contact pin.

Abstract: An electrical contact terminal includes a base portion for positioning and retaining the electrical contact terminal within a connector housing, an insulation displacement connecting portion extending upwardly from the base portion and comprising a pair of spaced apart arms defining an opening therebetween for receiving and making electrical contact with an electrical conductor, and a contact portion extending downwardly from the base portion and configured to float when the electrical contact terminal is retained and positioned within a connector housing. The contact portion includes a first arm, a second arm, and an arcuate base portion. The first arm extends downwardly and includes a first end attached to the base portion and an opposite second end. The second arm extends downwardly and includes a free first end closer to the base portion and an opposite second end farther from the base portion. The second arm is configured to deflect when making electrical contact with a mating contact pin.

Abstract: An electrical contact terminal includes a base portion for positioning and retaining the electrical contact terminal within a connector housing, an insulation displacement connecting portion extending upwardly from the base portion and comprising a pair of spaced apart arms defining an opening therebetween for receiving and making electrical contact with an electrical conductor, and a contact portion extending downwardly from the base portion and configured to float when the electrical contact terminal is retained and positioned within a connector housing. The contact portion includes a first arm, a second arm, and an arcuate base portion. The first arm extends downwardly and includes a first end attached to the base portion and an opposite second end. The second arm extends downwardly and includes a free first end closer to the base portion and an opposite second end farther from the base portion. The second arm is configured to deflect when making electrical contact with a mating contact pin.

Abstract: A strain relief for an electrical cable includes a longitudinal base portion including curved side portions extending upwardly from opposing longitudinal sides thereof, and first and second opposing strain relief latches extending from opposing lateral sides of the base portion. Each latch includes a curved connecting portion extending from a lateral side of the base portion first curving upwardly and then curving downwardly and terminating at an arm portion that extends downwardly. The arm portion is configured to resiliently deflect outwardly to accommodate secure attachment of the strain relief to an electrical connector.