Patents by Inventor Steven A. Fontana
Steven A. Fontana has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160128321Abstract: Disclosed are compounds that are conjugates of ladder frame polyether compounds and biologically active compounds or research compounds, pharmaceutical formulations comprising the conjugates, and methods of transporting the conjugates across biological membranes.Type: ApplicationFiled: January 13, 2016Publication date: May 12, 2016Inventors: Andrea Bourdelais, Daniel G. Baden, Alan Goodman, Steven Fontana
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Publication number: 20150342872Abstract: A method of administering a suspension of paclitaxel particles into the peritoneum is provided. A corresponding method of treating a disease, disorder or condition that is therapeutically responsive to paclitaxel is also provided. The methods provide improvements over comparator formulations containing an equivalent dose of paclitaxel.Type: ApplicationFiled: November 18, 2014Publication date: December 3, 2015Applicant: CRITITECH, INC.Inventors: Stephen K. WILLIAMSON, Charles J. DECEDUE, Steven A. FONTANA, Michael BALTEZOR
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Publication number: 20120077778Abstract: Disclosed are compounds that are conjugates of ladder frame polyether compounds and biologically active compounds or research compounds, pharmaceutical formulations comprising the conjugates, and methods of transporting the conjugates across biological membranes.Type: ApplicationFiled: September 29, 2010Publication date: March 29, 2012Inventors: Andrea Bourdelais, Daniel Baden, Allan Goodman, Steven Fontana
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Patent number: 6312723Abstract: Pharmaceutical formulations, in oral unit dosage forms, have one or more active ingredients or pharmaceutically acceptable salts, solvates, hydrates, or combinations thereof combined with at least one cyclodextrin.Type: GrantFiled: July 31, 2000Date of Patent: November 6, 2001Inventors: Robert R. Whittle, Frederick D. Sancilio, Grayson Walker Stowell, Douglas John Jenkins, Linda B. Whittall, Glenn Alan Meyer, Steven A. Fontana
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Patent number: 6268385Abstract: The present invention provides pharmaceutical formulations comprising compositions one or more of certain active pharmaceutical ingredients or pharmaceutically acceptable salts, solvates, hydrates, or combinations thereof wherein the ratio of said one or more active pharmaceutical ingredients in said formulations is essentially the same as the ratio of said active pharmaceutical ingredients in the corresponding, non-formulated drug substance. Methods for using the same are included.Type: GrantFiled: August 24, 2000Date of Patent: July 31, 2001Inventors: Robert R. Whittle, Frederick D. Sancilio, Grayson Walker Stowell, Douglas John Jenkins, Linda B. Whittall, Steven A. Fontana
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Patent number: 6262086Abstract: Pharmaceutical oral unit dosage forms are comprised of, per dosage unit, one or more active ingredients or pharmaceutically acceptable salts, solvates, hydrates, or combinations thereof.Type: GrantFiled: July 31, 2000Date of Patent: July 17, 2001Inventors: Robert R. Whittle, Frederick D. Sancilio, Grayson Walker Stowell, Douglas John Jenkins, Linda B. Whittall, Steven A. Fontana
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Patent number: 5770612Abstract: The present invention provides a method of alleviating one or more menstrual symptoms in a woman comprising administering to said woman in need of treatment an effective amount of a compound having the formula ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, --CH.sub.3, --CO--(C.sub.1 -C.sub.6 alkyl), or --CO--Ar in which Ar is optionally substituted phenyl; andR.sup.2 is selected from the group consisting of pyrrolidino, hexamethyleneimino and piperidino; or a pharmaceutically acceptable salt or solvate thereof.The present invention also provides the aforementioned method and further comprises administering to said woman an effective amount of at least one pharmaceutical agent selected from the group consisting of an analgesic, a diuretic, and an antihistamine, and compositions therefore.Type: GrantFiled: May 16, 1995Date of Patent: June 23, 1998Assignee: Eli Lilly and CompanyInventor: Steven A. Fontana
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Patent number: 5760061Abstract: The present invention provides a method of alleviating one or more menstrual symptoms in a woman comprising administering to said woman in need of treatment an effective amount of a compound having the formula ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, --CH.sub.3, --CO--(C.sub.1 -C.sub.6 alkyl), or --CO--Ar in which Ar is optionally substituted phenyl; andR.sup.2 is selected from the group consisting of pyrrolidino, hexamethyleneimino and piperidino; or a pharmaceutically acceptable salt or solvate thereof.The present invention also provides the aforementioned method and further comprises administering to said woman an effective amount of at least one pharmaceutical agent selected from the group consisting of an analgesic, a diuretic, and an antihistamine, and compositions therefore.Type: GrantFiled: May 16, 1995Date of Patent: June 2, 1998Assignee: Eli Lilly and CompanyInventor: Steven A. Fontana
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Patent number: 5599822Abstract: The present invention provides a method for minimizing the bone loss effect of a compound of formula II ##STR1## or a pharmaceutically acceptable salt thereof, wherein said formula II compound is administered to a mammal in need of treatment, comprising concurrently or sequentially administering to said mammal an effective amount of a compound of formula I ##STR2##Type: GrantFiled: June 6, 1995Date of Patent: February 4, 1997Assignee: Eli Lilly and CompanyInventors: George J. Cullinan, Steven A. Fontana
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Patent number: 5554600Abstract: The present invention provides a method for inhibiting endometriosis comprising administering to a woman in need of treatment an effective amount of a compound of formula I ##STR1## wherein R is hydrogen or methyl;R.sup.1 and R.sup.2 each are methyl or ethy, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached represent a saturated heterocyclic group; andX is bromo, chloro, fluoro, or hydrogen; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: January 20, 1995Date of Patent: September 10, 1996Assignee: Eli Lilly and CompanyInventor: Steven A. Fontana
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Patent number: 5554628Abstract: The present invention provides a method of minimizing the uterotrophic effect of non-steroidal antiestrogen compounds of formula II ##STR1## and wherein the variables are as defined in the specification and wherein said formula II compound is administered to a woman for the treatment or prevention of breast carcinoma, comprising concurrently or sequentially administering to said woman a compound of formula I ##STR2## wherein the variables are as defined in the specification.Type: GrantFiled: September 20, 1994Date of Patent: September 10, 1996Assignee: Eli Lilly and CompanyInventors: Henry U. Bryant, Steven A. Fontana
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Patent number: 5550150Abstract: A method of inhibiting one or more symptom of premenstrual syndrome/late luteal phase dysphoric disorder comprising administering to a female human in need of treatment an effective amount of a compound having the formula ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, --CH.sub.3, --CO--(C.sub.1 -C.sub.6 alkyl), or --CO--Ar, in which Ar is optionally substituted phenyl;R.sup.2 is selected from the group consisting of pyrrolidino, hexamethyleneimino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.Type: GrantFiled: August 29, 1994Date of Patent: August 27, 1996Assignee: Eli Lilly and CompanyInventor: Steven A. Fontana
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Patent number: 5550164Abstract: The present invention provides novel methods of inhibiting uterine fibroid disease and endometriosis in women comprising administering to a woman in need of treatment an effective amount of a compound of formula I ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different provided that, when R.sup.1 and R.sup.2 are the same, each is a methyl or ethyl group, and, when R.sup.1 and R.sup.2 are different, one of them is a methyl or ethyl group and the other is a benzyl group, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: April 4, 1995Date of Patent: August 27, 1996Assignee: Eli Lilly and CompanyInventor: Steven A. Fontana
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Patent number: 5489587Abstract: The present invention provides methods for inhibiting bone loss comprising administering to a mammal in need of treatment of a bone loss inhibiting amount of a compound of formula I ##STR1## wherein R is hydrogen or methyl;R.sup.1 and R.sup.2 each are methyl or ethyl, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached represent a saturated heterocyclic group; andX is bromo, chloro, fluoro, or hydrogen; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: January 20, 1995Date of Patent: February 6, 1996Assignee: Eli Lilly and CompanyInventor: Steven A. Fontana
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Patent number: 5462950Abstract: The present invention provides a method of alleviating one or more menstrual symptoms in a woman comprising administering to said woman in need of treatment an effective amount of a compound having the formula ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, --CH.sub.3, --CO--(C.sub.1 -C.sub.6 alkyl), or --CO--Ar in which Ar is optionally substituted phenyl; andR.sup.2 is selected from the group consisting of pyrrolidino, hexamethyleneimino and piperidino; or a pharmaceutically acceptable salt or solvate thereof.The present invention also provides the aforementioned method and further comprises administering to said woman an effective amount of at least one pharmaceutical agent selected from the group consisting of an analgesic, a diuretic, and an antihistamine, and compositions therefore.Type: GrantFiled: December 21, 1993Date of Patent: October 31, 1995Assignee: Eli Lilly and CompanyInventor: Steven A. Fontana
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Patent number: 5455275Abstract: The present invention provides novel methods of inhibiting uterine fibroid disease and endometriosis in women comprising administering to a woman in need of treatment an effective amount of a compound of formula I ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different provided that, when R.sup.1 and R.sup.2 are the same, each is a methyl or ethyl group, and, when R.sup.1 and R.sup.2 are different, one of them is a methyl or ethyl group and the other is a benzyl group, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 11, 1994Date of Patent: October 3, 1995Assignee: Eli Lilly and CompanyInventor: Steven A. Fontana
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Patent number: 5426123Abstract: The present invention provides a novel method of lowering serum cholesterol in humans comprising ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different provided that, when R.sup.1 and R.sup.2 are the same, each is a methyl or ethyl group, and, when R.sup.1 and R.sup.2 are different, one of them is a methyl or ethyl group and the other is a benzyl group, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 11, 1994Date of Patent: June 20, 1995Assignee: Eli Lilly and CompanyInventor: Steven A. Fontana
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Patent number: 5389670Abstract: A method of inhibiting one or more symptom of premenstrual syndrome/late luteal phase dysphoric disorder comprising administering to a female human in need of treatment an effective amount of a compound having the formula ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, --CH.sub.3, --CO--(C.sub.1 -C.sub.6 alkyl), or --CO--Ar, in which Ar is optionally substituted phenyl;R.sup.2 is selected from the group consisting of pyrrolidino, hexamethyleneimino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.Type: GrantFiled: December 21, 1993Date of Patent: February 14, 1995Assignee: Eli Lilly CompanyInventor: Steven A. Fontana
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Patent number: 5384332Abstract: The present invention provides novel methods of inhibiting aortal smooth muscle cell proliferation, particularly restenosis, in humans, comprising administering to a human in need of treatment an effective amount of a compound of formula I ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different provided that, when R.sup.1 and R.sup.2 are the same, each is a methyl or ethyl group, and, when R.sup.1 and R.sup.2 are different, one of them is a methyl or ethyl group and the other is a benzyl group, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 11, 1994Date of Patent: January 24, 1995Assignee: Eli Lilly and CompanyInventor: Steven A. Fontana