Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a proximal member having a proximal end, a distal end, and a proximal diameter. The guide extension catheter may additionally include a collar member attached to an extension portion of the proximal member, where the extension portion may be located at the distal end of the proximal member. The extension portion may allow a delivery device to be inserted through the guide extension catheter to extend along a surface of the extension portion and align with a lumen of a distal sheath of the guide extension catheter.

Abstract: A balloon system for balloon aortic valvuloplasty includes a delivery catheter, an outer expandable member coupled to the delivery catheter, and an inner balloon disposed within the outer expandable member. The outer expandable member has a first length, and a preset hourglass shape defined by first and second bulbous portions separated by a waist region. The inner balloon is non-compliant and has a second length shorter than the first length.

Abstract: Intravascular imaging catheters and methods for making and using intravascular imaging catheters are disclosed. An example intravascular imaging catheter may include an elongate catheter shaft having a distal end region and a proximal region. The distal end region may include a side port. An imaging core may be disposed within the elongate catheter shaft. The imaging core may include an imaging device configured to be slidable within the elongate catheter shaft and through the side port.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a proximal member having a proximal end, a distal end, and a proximal diameter. The guide extension catheter may additionally include a collar member attached to the distal end of the proximal member, the collar member comprising a base portion and one or more ribs connected to the base portion and extending distally away from the base portion. In still some additional embodiments, the guide extension catheter may further include a distal sheath member attached to the collar member, the distal sheath member having a distal diameter larger than the proximal diameter.

Abstract: An apparatus for treating a total occlusion in a blood vessel may include a self-orienting device including an elongate shaft and an inflatable orienting element. The shaft includes an inflation lumen having a first noncircular shape and a working lumen having a second noncircular shape. The inflatable orienting element includes first and second inflatable members extending laterally from the shaft. An outer diameter of the shaft is 0.045 inches or less, a cross-sectional area of the first noncircular cross-sectional shape is at least 0.00013 square inches, and a cross-sectional area of the second noncircular cross-sectional shape is at least 0.00056 square inches. The shaft may include a distal tail extending distally from the inflatable orienting element, the distal tail being at least 15 millimeters long. The shaft may include a plurality of first apertures communicating with the working lumen and disposed in the distal tail.

Abstract: A recanalization catheter for facilitating reentry into a lumen of a vessel having an occlusion therein from a subintimal space in a wall of the vessel. The recanalization catheter includes a catheter shaft extending distally from a hub. The catheter shaft defines a guidewire lumen extending therethrough. First and second inflatable balloon members are disposed on a distal end region of the catheter shaft. The catheter shaft includes an inflation lumen in fluid communication with the first and second inflatable balloon members. A lateral opening which is in communication with the guidewire lumen opens to an exterior of the catheter shaft between the first and second inflatable balloon members on a first side of the catheter shaft. The catheter shaft also includes an imaging lumen extending through the catheter shaft configured to receive an IVUS imaging device therein.

Abstract: Intravascular imaging devices as well as methods for making and using intravascular imaging devices are disclosed. An intravascular imaging device, may include a catheter shaft assembly including a telescoping assembly and a catheter body. The catheter body may include a hypotube region, an imaging window region, and a distal end region having a guidewire lumen formed therein. At least a portion of the hypotube region may have a plurality of slots formed therein. An imaging core may be disposed within the catheter shaft assembly.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a proximal member having a proximal end, a distal end, and a proximal diameter. The guide extension catheter may additionally include a collar member attached to an extension portion of the proximal member, where the extension portion may be located at the distal end of the proximal member. The extension portion may allow a delivery device to be inserted through the guide extension catheter to extend along a surface of the extension portion and align with a lumen of a distal sheath of the guide extension catheter.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a proximal member having a proximal end, a distal end, and a proximal diameter. The guide extension catheter may additionally include a collar member attached to an extension portion of the proximal member, where the extension portion may be located at the distal end of the proximal member. The extension portion may allow a delivery device to be inserted through the guide extension catheter to extend along a surface of the extension portion and align with a lumen of a distal sheath of the guide extension catheter.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a proximal member having a proximal end, a distal end, and a proximal diameter. The guide extension catheter may additionally include a collar member attached to the distal end of the proximal member, the collar member comprising a base portion and one or more ribs connected to the base portion and extending distally away from the base portion. In still some additional embodiments, the guide extension catheter may further include a distal sheath member attached to the collar member, the distal sheath member having a distal diameter larger than the proximal diameter.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a proximal member having a proximal end, a distal end, and a proximal diameter. The guide extension catheter may additionally include a collar member attached to the distal end of the proximal member, the collar member comprising a base portion and one or more ribs connected to the base portion and extending distally away from the base portion. In still some additional embodiments, the guide extension catheter may further include a distal sheath member attached to the collar member, the distal sheath member having a distal diameter larger than the proximal diameter.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a proximal shaft having a first outer diameter. A distal sheath may be attached to the proximal shaft and may have a second outer diameter greater than the first outer diameter. The distal sheath may be designed to extend past a coronary ostium and into a coronary artery so that another medical device can pass therethrough toward the coronary artery. An expandable balloon may be coupled to the distal sheath.

Abstract: A catheter system (100) for treating a treatment site (106) within or adjacent to the vessel wall of a blood vessel (108), or the heart valve, includes an energy source (124), a balloon (104), an energy guide (122A), and a balloon integrity protection system (142). The energy source (124) generates energy. The balloon (104) is positionable substantially adjacent to the treatment site (106). The balloon (104) has a balloon wall (130) that defines a balloon interior (146). The balloon (104) is configured to retain a balloon fluid (132) within the balloon interior (146). The energy guide (122A) is configured to receive energy from the energy source (124) and guide the energy into the balloon interior (146) so that plasma is formed in the balloon fluid (132) within the balloon interior (146). The balloon integrity protection system (142) is operatively coupled to the balloon (104).

Abstract: In some examples, formatting semi-structured data in a database includes obtaining semi-structured data in a column store database, assigning the semi-structured data to a semi-structured column with a key and value format, and formatting the semi-structured data with an optimal search format.

Abstract: Imaging medical device systems and methods for making and using imaging medical device systems are disclosed. An example imaging medical device system may include an elongate shaft having a distal end region. An imaging assembly may be disposed within the elongate shaft. The imaging assembly may include a drive cable, a housing coupled to the drive cable, and a transducer coupled to the housing. A bubble-reducing member may be disposed adjacent to the drive cable.

Abstract: Medical devices, medical device systems, and methods for using the same are disclosed. An example medical device system may include a guide catheter having a proximal end, a distal end, and a lumen extending therebetween. The guide catheter may be designed to guide a therapeutic catheter to a target site. A guidewire may be disposed within the lumen of the guide catheter. The system may also include a trap balloon catheter including a catheter shaft and a balloon coupled to the catheter shaft. The trap balloon catheter may be designed to extend through the lumen of the guide catheter to a position adjacent to the distal end of the guide catheter. A trap balloon retainer may be coupled to the catheter shaft. The trap balloon retainer may be designed to prevent a distal end of the trap balloon catheter from extending distally beyond the distal end of the guide catheter.

Abstract: Disclosed are anti-HAAH antibodies and derivatives thereof conjugated to cytotoxic, cytostatic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods for the treatment of HAAH-expressing cancers, comprising administering to a subject the disclosed pharmaceutical compositions.

Abstract: In an example, data from a source location is merged into a target location containing existing data, in which the source location and the target location contain tuples of data. For each tuple in the source location, during a single operation, a determination is made as to whether there is a matched tuple in the target location that satisfies a predetermined condition. For each matched tuple that satisfies the predetermined condition, the matched tuple in the target location is updated with a count value that is equal to a count of the matched tuple in the source location and the target location. In addition, for each tuple that does not have a matched tuple that satisfies the predetermined condition, the unmatched tuple is inserted into the target location.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a proximal member having a proximal end, a distal end, and a proximal diameter. The guide extension catheter may additionally include a collar member attached to the distal end of the proximal member, the collar member comprising a base portion and one or more ribs connected to the base portion and extending distally away from the base portion. In still some additional embodiments, the guide extension catheter may further include a distal sheath member attached to the collar member, the distal sheath member having a distal diameter larger than the proximal diameter.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a proximal member having a proximal end, a distal end, and a proximal diameter. The guide extension catheter may additionally include a collar member attached to the distal end of the proximal member, the collar member comprising a base portion and one or more ribs connected to the base portion and extending distally away from the base portion. In still some additional embodiments, the guide extension catheter may further include a distal sheath member attached to the collar member, the distal sheath member having a distal diameter larger than the proximal diameter.