Abstract: An ozone delivery system for delivering and manufacturing a measured amount of an ozone/oxygen admixture, which is able to measure, control, report and differentiate between delivered-ozone and absorbed-dose of ozone. Improved gas-fluid contacting devices that maximize gas-fluid mass transfer may be included. All gas contacting surfaces of the system, including one or more gas-fluid contacting devices are made from ozone-inert construction materials that generally do not absorb ozone or introduce amounts of contaminants or deleterious byproducts of oxidation into a fluid or non-fluid target from ozone oxidation.

Abstract: An ozone delivery system for delivering and manufacturing a measured amount of an ozone/oxygen admixture, which is able to measure, control, report and differentiate between delivered-ozone and absorbed-dose of ozone. Improved gas-fluid contacting devices that maximize gas-fluid mass transfer may be included. All gas contacting surfaces of the system, including one or more gas-fluid contacting devices are made from ozone-inert construction materials that generally do not absorb ozone or introduce amounts of contaminants or deleterious byproducts of oxidation into a fluid or non-fluid target from ozone oxidation.

Abstract: Methods are provided for treatment of acute ischemic brain stroke based on the delivery of a measured amount of ozone to a sample of a mammalian patient's blood, blood fractionate or other biological fluid through the use of an ozone delivery system. The ozone-treated fluid, having absorbed a quantifiable absorbed-dose of ozone, is subsequently reinfused into the same patient and the autologous blood sample provides therapeutic effects to the patient, such as reduction in edema associated with the ischemic penumbra, improvement in impaired blood flow to the area surrounding the infarct, relaxation of the vascular endothelium and reduction of inflammation.

Abstract: Methods for therapeutic treatment of inflammatory conditions in a mammalian patient provide clinical benefits including reduction of inflammation, vasorelaxation, reduction in edema and increased blood flow, the methods generally comprising extracorporeal treatment of blood, blood fractionate, or other biological fluid to expose such fluids to a precise, measured amount of ozone to produce a blood or biological fluid having a quantified absorbed dose of ozone, and reinfusing the treated biological fluid to the patient to provide therapeutic effects beneficial in the treatment of inflammatory disorders and related symptoms or conditions.

Abstract: Methods of treating cardiovascular diseases, including atherosclerosis, peripheral arterial occlusive disease, congestive heart failure, hypertension, cerebrovascular disease, dyslipidemia and vasospastic disorders such as Raynaud's disease, in a mammalian patient involve extracorporeally subjecting an amount of blood, blood fractionate or other biological fluid from a patient to a measured amount of ozone delivered by an ozone delivery system, resulting in the absorption of a quantifiable absorbed-dose of ozone and reinfusing the treated fluid into the patient to therapeutically treat cardiovascular disease and related conditions.

Abstract: An ozone delivery system for delivering and manufacturing a measured amount of an ozone/oxygen admixture, which is able to measure, control, report and differentiate between delivered-ozone and absorbed-dose of ozone. Improved gas-fluid contacting devices that maximize gas-fluid mass transfer may be included. All gas contacting surfaces of the system, including one or more gas-fluid contacting devices are made from ozone-inert construction materials that generally do not absorb ozone or introduce amounts of contaminants or deleterious byproducts of oxidation into a fluid or non-fluid target from ozone oxidation.

Abstract: A method to inactivate viruses in a biological fluid and a non-fluid target to produce a non-infectious biological fluid or non-fluid target. The method involves subjecting an amount of a fluid or a target containing a virus including lipid-enveloped viruses, to an amount of ozone delivered by an ozone delivery system. The method may provide for maintaining the biological integrity of the biological fluid or the non-fluid target. All gas contacting surfaces of the system, including one or more gas-fluid contact devices are made from ozone-inert construction.

Abstract: An ozone delivery system for delivering and manufacturing a measured amount of an ozone/oxygen admixture, which is able to measure, control, report and differentiate between delivered-ozone and absorbed-dose of ozone. Improved gas-fluid contacting devices that maximize gas-fluid mass transfer may be included. All gas contacting surfaces of the system, including one or more gas-fluid contacting devices are made from ozone-inert construction materials that generally do not absorb ozone or introduce amounts of contaminants or deleterious byproducts of oxidation into a fluid or non-fluid target from ozone oxidation.

Abstract: A method to inactivate viruses in a biological fluid and a non-fluid target to produce a non-infectious biological fluid or non-fluid target. The method involves subjecting an amount of a fluid or a target containing a virus including lipid-enveloped viruses, to an amount of ozone delivered by an ozone delivery system. The method may provide for maintaining the biological integrity of the biological fluid or the non-fluid target. All gas contacting surfaces of the system, including one or more gas-fluid contact devices are made from ozone-inert construction.

Abstract: An ozone delivery system for delivering and manufacturing a measured amount of an ozone/oxygen admixture, which is able to measure, control, report and differentiate between delivered-ozone and absorbed-dose of ozone. Improved gas-fluid contacting devices that maximize gas-fluid mass transfer may be included. All gas contacting surfaces of the system, including one or more gas-fluid contacting devices are made from ozone-inert construction materials that generally do not absorb ozone or introduce amounts of contaminants or deleterious byproducts of oxidation into a fluid or non-fluid target from ozone oxidation.