Abstract: A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making bispecific antibodies having universal light chains using mice as described herein, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, and host cells are provided. Bispecific antibodies capable of binding first and second antigens are provided, wherein the first and second antigens are separate epitopes of a single protein or separate epitopes on two different proteins are provided.

Abstract: A system, method, and apparatus for Internet Protocol television streaming are disclosed. An example apparatus includes a plurality of remote access points. Each remote access point provides line termination for television programming received via a data feed from a television service provider. The respective remote access point is specifically assigned to an application operating on a client device for maintaining a one-to-one correspondence between the application and the respective data feed from the television service provider.

Abstract: A punch item management tool may be provided that coordinates and guides the process of taking a punch item from creation to completion. As one possibility, the punch item management tool may coordinate and guide the interactions between a creator of a punch item, a punch item manager for the punch item, and one or more assignees that are expected to perform work on the punch item. As another possibility, the punch item management tool may coordinate and guide the interactions between an individual serving the dual role of creator and punch item manager for a punch item and one or more assignees that are expected to perform work on the punch item. In either case, the punch item management tool may provide a user interface including various views through which these individuals may interact with one or more punch items.

Abstract: Non-human animals comprising a human or humanized IL-4 and/or IL-4R? nucleic acid sequence are provided. Non-human animals that comprise a replacement of the endogenous IL-4 gene and/or IL-4R? gene with a human IL-4 gene and/or IL-4R? gene in whole or in part, and methods for making and using the non-human animals, are described. Non-human animals comprising a human or humanized IL-4 gene under control of non-human IL-4 regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4-encoding sequence with human IL-4-encoding sequence at an endogenous non-human IL-4 locus. Non-human animals comprising a human or humanized IL-4R? gene under control of non-human IL-4R? regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4R?-encoding sequence with human or humanized IL-4R?-encoding sequence at an endogenous non-human C IL-4R? locus.

Abstract: Shoulder joint implants are disclosed herein for use in shoulder reconstruction that are configured to facilitate the inclusion a central bone screw for augmented bone fixation. The implant can include a baseplate (or metaglene) configured to secure a glenosphere or other prosthetic component to the glenoid. To facilitate lateral or proximal insertion of a central bone screw through the implant, a throughbore defined along the central axis of the metaglene can be widened to accommodate the maximum diameter of the screw. To enable fixation of the glenosphere to the metaglene, a collet can be configured to engage the smaller diameter of a glenosphere coupling element and inserted into the central throughbore. The collet and the bone screw can be separate parts, thereby making insertion of the bone screw optional. Alternatively, the collet and bone screw can be integrated together to form a unitary construct.

Abstract: Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided.

Abstract: Genetically modified non-human animals are provided that may be used to model human hematopoietic cell development, function, or disease. The genetically modified non-human animals comprise a nucleic acid encoding human IL-6 operably linked to an IL-6 promoter. In some instances, the genetically modified non-human animal expressing human IL-6 also expresses at least one of human M-CSF, human IL-3, human GM-CSF, human SIRPa or human TPO. In some instances, the genetically modified non-human animal is immunodeficient. In some such instances, the genetically modified non-human animal is engrafted with healthy or diseased human hematopoietic cells. Also provided are methods for using the subject genetically modified non-human animals in modeling human hematopoietic cell development, function, and/or disease, as well as reagents and kits thereof that find use in making the subject genetically modified non-human animals and/or practicing the subject methods.

Abstract: The invention relates to a system (400) comprising a vehicle (402), an arm assembly (408), first and second cable portions (410a, 410b), at least one cable actuator (406), and an air supply line. The vehicle has a pneumatic source of pressurized air. The arm assembly has an end effector releasably coupled to an end of an axially-extendable arm coupled to the vehicle. The end effector has a gladhand coupling portion. The air supply line can be coupled to the end effector and can deliver pressurized air from the pneumatic source to a braking system of the trailer when the gladhand coupling portion is coupled to the gladhand receptacle of a trailer. After coupling to the gladhand receptacle, the end effector can be disconnected from the arm assembly to allow the remainder of the arm assembly to be stowed.

Abstract: Genetically modified non-human animals expressing human EPO from the animal genome are provided. Also provided are methods for making non-human animals expressing human EPO from the non-human animal genome, and methods for using non-human animals expressing human EPO from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human erythropoiesis and erythrocyte function; in modeling human pathogen infection of erythrocytes; in in vivo screens for agents that modulate erythropoiesis and/or erythrocyte function, e.g. in a healthy or a diseased state; in in vivo screens for agents that are toxic to erythrocytes or erythrocyte progenitors; in in vivo screens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on erythrocytes or erythrocyte progenitors; in in vivo screens of erythrocytes or erythrocyte progenitors from an individual to predict the responsiveness of an individual to a disease therapy.

Abstract: Systems and methods are provided for splicing airframe components. One embodiment is a method for assembling an airframe of an aircraft. The method includes forming a first skin of a first circumferential section of fuselage, the first skin including a distal portion comprising a lip and a shoulder, aligning a second skin of a second circumferential section of fuselage with the shoulder such that the lip overlaps the second skin, and affixing the first skin and the second skin together via a circumferential splice.

Abstract: Mice, embryos, cells, and tissues having a restricted immunoglobulin heavy chain locus and an ectopic sequence encoding one or more ADAM6 proteins are provided. In various embodiments, mice are described that have humanized endogenous immunoglobulin heavy chain loci and are capable of expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof that is functional in a male mouse. Mice, embryos, cells, and tissues having an immunoglobulin heavy chain locus characterized by a single human VH gene segment, a plurality of human DH gene segments and a plurality of human JH gene segments and capable expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof are also provided.

Abstract: The present application is directed to a closure for a container having a generally annular neck defining a container opening having a central axis, the closure including: an annular top wall having opposed inner and outer surfaces; a generally annular skirt extending downwardly from the inner surface of the top wall, the generally annular skirt having opposed outer and inner surfaces; and an elastic annular seal member extending downwardly from an inner surface of the top wall, the annular seal member adapted to engage the inner surface of the neck of the container.

Abstract: A system for providing a quick response (QR) code associated with an injection system is disclosed. The system includes the injection system and at least one processor. The at least one processor is programmed or configured to: receive data associated with the injection system; generate a network resource based on the data associated with the injection system, wherein, when generating the network resource, the at least one processor is programmed or configured to encode the data associated with the injection system into the network resource; generate a QR code based on the network resource; and display the QR code on a display screen of the injection system.

Abstract: A system, method, and apparatus for Internet Protocol television streaming are disclosed. An example apparatus includes a plurality of remote access points. Each remote access point provides line termination for television programming received via a data feed from a television service provider. The respective remote access point is specifically assigned to an application operating on a client device for maintaining a one-to-one correspondence between the application and the respective data feed from the television service provider.

Abstract: A system, method, and apparatus for Internet Protocol television streaming are disclosed. An example apparatus includes a receiver configured to receive encrypted television programming via a secure communication channel from a remote access point that receives the television programming via a data feed from a television service provider. The example receiver is configured to decrypt the encrypted television programming, decode the decrypted television programming, and select at least one of a channel or content of the decoded and decrypted television programming based on input received from a user via an interface. The example apparatus also includes a display device configured to receive and display the selected at least one of a channel or content of the decoded and decrypted television programming.

Abstract: A packaged electrical device that includes a cured adhesive layer and a cured layer of die attach material coupled between a semiconductor die and a substrate. The packaged electrical device may also include wire bonds coupled between the substrate and leads of the semiconductor die. In addition, the packaged electrical device may be encapsulated in molding compound. A method for fabricating a packaged electrical device. The method includes printing a layer of die attach material over a semiconductor wafer and applying a layer of 2-in-1 die attach film over the layer of die attach material. The method also includes singulating the semiconductor wafer to create a semiconductor die and placing the semiconductor die onto a substrate. In addition the method includes wire bonding the substrate to leads of the semiconductor die and encapsulating the device in molding compound.

Abstract: The present application is directed to a closure for a container having a generally annular neck defining a container opening having a central axis, the closure including: an annular top wall having opposed inner and outer surfaces; a generally annular skirt extending downwardly from the inner surface of the top wall, the generally annular skirt having opposed outer and inner surfaces; and an elastic annular seal member extending downwardly from an inner surface of the top wall, the annular seal member adapted to engage the inner surface of the neck of the container.

Abstract: Systems, methods, and apparatuses for installing a software product using timestamp validation and system identification validation are disclosed. An example method to lock a software product in a software wrapper includes determining a unique hard drive serial number of a user device to which the software product is to be installed and generating a hash number of the unique hard drive serial number. The example method also includes determining a campaign identifier of the software product from a secure variable within the software product and generating a date-time code based on a current date and time. The method further includes assembling the date-time code and the campaign identifier into an unlock code, encrypting the unlock code using the hash number as a passphrase key to create an encrypted unlock code, and applying the encrypted unlock code to an end of a filename of an installer using a command line parameter.

Abstract: A mobile hologram apparatus is disclosed. An example apparatus includes a sheet folded along preformed creases into a pyramid structure configured to be actuated between a compressed state and an uncompressed state. The pyramid structure has a base section and a top section connected by four side sections. The pyramid structure in the compressed state has a height that is less than 1/10th the height of the pyramid structure in the uncompressed state. The apparatus also includes an elastic band connected to a perimeter of the base section of the pyramid structure and configured to cause the pyramid structure to self-actuate from the compressed state to the uncompressed state.