Patents by Inventor Steven A. Reese

Steven A. Reese has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11150460
    Abstract: Disclosed is a cell culture microscopy slide comprising an optically transparent generally flat supporting surface (20) including upper and lower opposed substrate surfaces (27,28). A peripheral frame (40) surrounds the substrate (20), the frame (40) having a lower frame surface (44) and an upper frame surface (42). The lower frame surface (44) and the lower substrate surface (28) are generally flush. The upper frame surface (42) lies above the upper substrate surface (27), to form a well (32), and the upper and lower frame surfaces (42,44) are continuously flat and generally parallel. The substrate is preferably glass having a thickness of 1.7 mm.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: October 19, 2021
    Assignee: LEICA MICROSYSTEMS CMS GMBH
    Inventors: Paul C. Goodwin, Jeremy R. Cooper, Steven A. Reese, Kathryn Buckanan, Jeffrey D. Bert, James T. Newberry
  • Patent number: 10067330
    Abstract: Methods and apparatus are described for delivering index-matching immersion liquid in high numerical-aperture optical microscopy and lithography. An array of immersion liquid droplets is delivered to a specimen substrate or specimen substrate cover by an immersion liquid printing apparatus. An immersion liquid reservoir provides immersion liquid to the printer by a precision pump. The printer delivers immersion liquid to the substrate or substrate cover in arrays of immersion liquid droplets of defined volumes and array patterns. The volumes and patterns of array droplets delivered to the substrate or substrate cover are optimized to maintain adequate immersion liquid between the substrate or substrate cover and an immersion objective while avoiding the formation of air bubbles in the immersion liquid and the accumulation of excess volumes of immersion liquid.
    Type: Grant
    Filed: June 7, 2016
    Date of Patent: September 4, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: William M. Dougherty, Paul C. Goodwin, Steven A. Reese, David A. Stewart
  • Patent number: 9507136
    Abstract: Illumination system for a microscope system capable of being mode-switchable between a first and a second illumination mode, comprising one source of light for providing a collimated beam of light, at least one selector mirror capable of being positioned in at least two positions to redirect the beam of light in two different beam paths, the first beam path being a direct exit beam path wherein the selector mirror redirects the beam of light along an exit beam path to provide a first illumination mode, the second beam path is a mirror loop path comprising two or more mirrors arranged to redirect the beam of light onto the selector mirror such that it is redirected by the selector mirror a second time along the exit beam path, and wherein mirror loop path comprises at least one optical element arranged to optically alter the beam of light to provide the second illumination mode.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: November 29, 2016
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: Jeremy R. Cooper, William M. Dougherty, Steven A. Reese
  • Publication number: 20160282597
    Abstract: Methods and apparatus are described for delivering index-matching immersion liquid in high numerical-aperture optical microscopy and lithography. An array of immersion liquid droplets is delivered to a specimen substrate or specimen substrate cover by an immersion liquid printing apparatus. An immersion liquid reservoir provides immersion liquid to the printer by a precision pump. The printer delivers immersion liquid to the substrate or substrate cover in arrays of immersion liquid droplets of defined volumes and array patterns. The volumes and patterns of array droplets delivered to the substrate or substrate cover are optimized to maintain adequate immersion liquid between the substrate or substrate cover and an immersion objective while avoiding the formation of air bubbles in the immersion liquid and the accumulation of excess volumes of immersion liquid.
    Type: Application
    Filed: June 7, 2016
    Publication date: September 29, 2016
    Inventors: William M. Dougherty, Paul C. Goodwin, Steven A. Reese, David A. Stewart
  • Patent number: 9366851
    Abstract: Methods and apparatus are described for delivering index-matching immersion liquid in high numerical-aperture optical microscopy and lithography. An array of immersion liquid droplets is delivered to a specimen substrate or specimen substrate cover by an immersion liquid printing apparatus. An immersion liquid reservoir provides immersion liquid to the printer by a precision pump. The printer delivers immersion liquid to the substrate or substrate cover in arrays of immersion liquid droplets of defined volumes and array patterns. The volumes and patterns of array droplets delivered to the substrate or substrate cover are optimized to maintain adequate immersion liquid between the substrate or substrate cover and an immersion objective while avoiding the formation of air bubbles in the immersion liquid and the accumulation of excess volumes of immersion liquid.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: June 14, 2016
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: William M. Dougherty, Paul C. Goodwin, Steven A. Reese, David A. Stewart
  • Patent number: 9256066
    Abstract: Irradiance control systems (“ICSs”) that control the irradiance of a beam of light are disclosed. ICSs include in a beam translator and a beam launch. The beam translator translates the beam substantially perpendicular to the propagating direction of the beam with a desired displacement so that the beam launch can remove a portion of the translated beam and the beam can be output with a desired irradiance. The beam launch attenuates the irradiance of the beam based on the amount by which the beam is translated. ISCs can be incorporated into fluorescent microscopy instruments to provide high-speed, fine-tune control over the irradiance of excitation beams.
    Type: Grant
    Filed: January 16, 2012
    Date of Patent: February 9, 2016
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: Jeremy R. Cooper, Steven A. Reese, William M. Dougherty
  • Publication number: 20140320958
    Abstract: Illumination system for a microscope system capable of being mode-switchable between a first and a second illumination mode, comprising one source of light for providing a collimated beam of light, at least one selector mirror capable of being positioned in at least two positions to redirect the beam of light in two different beam paths, the first beam path being a direct exit beam path wherein the selector mirror redirects the beam of light along an exit beam path to provide a first illumination mode, the second beam path is a mirror loop path comprising two or more mirrors arranged to redirect the beam of light onto the selector mirror such that it is redirected by the selector mirror a second time along the exit beam path, and wherein mirror loop path comprises at least one optical element arranged to optically alter the beam of light to provide the second illumination mode.
    Type: Application
    Filed: November 14, 2012
    Publication date: October 30, 2014
    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: Jeremy R. Cooper, William M. Dougherty, Steven A. Reese
  • Patent number: 8115150
    Abstract: A new optical substrate design allows a target to be illuminated with minimal illumination of undesired surfaces within the image collection ray path.
    Type: Grant
    Filed: December 30, 2008
    Date of Patent: February 14, 2012
    Assignee: Applied Precision, Inc.
    Inventors: Carl S. Brown, Steven A. Reese
  • Patent number: 7683345
    Abstract: A system and method employing photokinetic techniques in cell biology imaging applications are disclosed. Systems and methods of acquiring image data of an object may comprise: selectively inducing photoactivation of material at a site on the object; performing an optical axis integration scan; simultaneously executing a time delay integration scan sequence; and processing acquired image data in accordance with one or more desired analyses. Various methodologies and applications may include, inter alia, selective photobleaching of a site on the object, diffusion rate, velocity, and wave-front propagation analyses, multi-dimensional analyses of dispersion characteristics, biomolecular binding in cellular organelles, and photoactivation assisted systematic image segmentation for the study of cellular components.
    Type: Grant
    Filed: August 4, 2008
    Date of Patent: March 23, 2010
    Assignee: Applied Precision, Inc.
    Inventors: Paul C. Goodwin, Carl S. Brown, Steven A. Reese
  • Patent number: 7608840
    Abstract: A system and method employing photokinetic techniques in cell biology imaging applications are disclosed. Systems and methods of acquiring image data of an object may comprise: selectively inducing photoactivation of material at a site on the object; performing an optical axis integration scan; simultaneously executing a time delay integration scan sequence; and processing acquired image data in accordance with one or more desired analyses. Various methodologies and applications may include, inter alia, selective photobleaching of a site on the object, diffusion rate, velocity, and wave-front propagation analyses, multi-dimensional analyses of dispersion characteristics, biomolecular binding in cellular organelles, and photoactivation assisted systematic image segmentation for the study of cellular components.
    Type: Grant
    Filed: August 4, 2008
    Date of Patent: October 27, 2009
    Assignee: Applied Precision, LLC
    Inventors: Paul C. Goodwin, Carl S. Brown, Steven A. Reese
  • Publication number: 20090206238
    Abstract: A new optical substrate design allows a target to be illuminated with minimal illumination of undesired surfaces within the image collection ray path.
    Type: Application
    Filed: December 30, 2008
    Publication date: August 20, 2009
    Applicant: Applied Precision, Inc. Delaware corporation
    Inventors: Carl S. Brown, Steven A. Reese
  • Publication number: 20090109416
    Abstract: Methods and apparatus are described for delivering index-matching immersion liquid in high numerical-aperture optical microscopy and lithography. An array of immersion liquid droplets is delivered to a specimen substrate or specimen substrate cover by an immersion liquid printing apparatus. An immersion liquid reservoir provides immersion liquid to the printer by a precision pump. The printer delivers immersion liquid to the substrate or substrate cover in arrays of immersion liquid droplets of defined volumes and array patterns. The volumes and patterns of array droplets delivered to the substrate or substrate cover are optimized to maintain adequate immersion liquid between the substrate or substrate cover and an immersion objective while avoiding the formation of air bubbles in the immersion liquid and the accumulation of excess volumes of immersion liquid.
    Type: Application
    Filed: September 11, 2008
    Publication date: April 30, 2009
    Applicant: APPLIED PRECISION, INC.
    Inventors: WILLIAM M. DOUGHERTY, Paul C. Goodwin, Steven A. Reese, David A. Stewart
  • Publication number: 20090026386
    Abstract: A system and method employing photokinetic techniques in cell biology imaging applications are disclosed. Systems and methods of acquiring image data of an object may comprise: selectively inducing photoactivation of material at a site on the object; performing an optical axis integration scan; simultaneously executing a time delay integration scan sequence; and processing acquired image data in accordance with one or more desired analyses. Various methodologies and applications may include, inter alia, selective photobleaching of a site on the object, diffusion rate, velocity, and wave-front propagation analyses, multi-dimensional analyses of dispersion characteristics, biomolecular binding in cellular organelles, and photoactivation assisted systematic image segmentation for the study of cellular components.
    Type: Application
    Filed: August 4, 2008
    Publication date: January 29, 2009
    Applicant: Applied Precision, LLC
    Inventors: Paul C. Goodwin, Carl S. Brown, Steven A. Reese
  • Publication number: 20090028413
    Abstract: A system and method employing photokinetic techniques in cell biology imaging applications are disclosed. Systems and methods of acquiring image data of an object may comprise: selectively inducing photoactivation of material at a site on the object; performing an optical axis integration scan; simultaneously executing a time delay integration scan sequence; and processing acquired image data in accordance with one or more desired analyses. Various methodologies and applications may include, inter alia, selective photobleaching of a site on the object, diffusion rate, velocity, and wave-front propagation analyses, multi-dimensional analyses of dispersion characteristics, biomolecular binding in cellular organelles, and photoactivation assisted systematic image segmentation for the study of cellular components.
    Type: Application
    Filed: August 4, 2008
    Publication date: January 29, 2009
    Applicant: Applied Precision, LLC
    Inventors: Paul C. Goodwin, Carl S. Brown, Steven A. Reese
  • Patent number: 7408176
    Abstract: A system and method employing photokinetic techniques in cell biology imaging applications are disclosed. Systems and methods of acquiring image data of an object may comprise: selectively inducing photoactivation of material at a site on the object; performing an optical axis integration scan; simultaneously executing a time delay integration scan sequence; and processing acquired image data in accordance with one or more desired analyses. Various methodologies and applications may include, inter alia, selective photobleaching of a site on the object, diffusion rate, velocity, and wave-front propagation analyses, multi-dimensional analyses of dispersion characteristics, biomolecular binding in cellular organelles, and photoactivation assisted systematic image segmentation for the study of cellular components.
    Type: Grant
    Filed: June 18, 2004
    Date of Patent: August 5, 2008
    Assignee: Applied Precision, LLC
    Inventors: Paul C. Goodwin, Carl S. Brown, Steven A. Reese
  • Patent number: 7283253
    Abstract: An image acquisition system and method employing multi-axis integration (MAI) may incorporate both optical axis integration (OAI) and time-delay integration (TDI) techniques. Disclosed MAI systems and methods may integrate image data in the z direction as the data are acquired, projecting the image data prior to deconvolution. Lateral translation of the image plane during the scan in the z direction may allow large areas to be imaged in a single scan sequence.
    Type: Grant
    Filed: March 13, 2003
    Date of Patent: October 16, 2007
    Assignee: Applied Precision, LLC
    Inventors: Steven A. Reese, Carl S. Brown, Paul C. Goodwin
  • Publication number: 20040108641
    Abstract: A system and method of selectively fastening a substrate to a limited travel staging system are disclosed. In accordance with one aspect of a substrate holder, a securing mechanism may be manually or automatically moved in a repeatable manner such that a selected region of a substrate can be moved into the precision travel range of a highly accurate staging system. Some embodiments of a substrate holder may comprise an indexing system enabling referenced movements such that one or more selected substrate regions may be moved relative to the stage.
    Type: Application
    Filed: September 5, 2003
    Publication date: June 10, 2004
    Inventors: Steven A. Reese, Peter C. Lombrozo, James A. Roecker, Paul C. Goodwin
  • Publication number: 20030222197
    Abstract: An image acquisition system and method employing multi-axis integration (MAI) may incorporate both optical axis integration (OAI) and time-delay integration (TDI) techniques. Disclosed MAI systems and methods may integrate image data in the z direction as the data are acquired, projecting the image data prior to deconvolution. Lateral translation of the image plane during the scan in the z direction may allow large areas to be imaged in a single scan sequence.
    Type: Application
    Filed: March 13, 2003
    Publication date: December 4, 2003
    Inventors: Steven A. Reese, Carl S. Brown, Paul C. Goodwin
  • Publication number: 20020005493
    Abstract: The method of illumination of a microarray sample may contribute to the signal-to-background ratio. An oblique illumination technique is used to reduce the reflections from the sample to the detector. The sample may also be moved to the backside of the sample support to reduce the reflections caused by the sample support. In addition, a parallel scanning technique may be used to ensure proper alignment of the sample.
    Type: Application
    Filed: April 4, 2001
    Publication date: January 17, 2002
    Inventors: Steven A. Reese, Steven C. Quarre, Carl S. Brown, Paul C. Goodwin