Patents by Inventor Steven A. Reese
Steven A. Reese has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11150460Abstract: Disclosed is a cell culture microscopy slide comprising an optically transparent generally flat supporting surface (20) including upper and lower opposed substrate surfaces (27,28). A peripheral frame (40) surrounds the substrate (20), the frame (40) having a lower frame surface (44) and an upper frame surface (42). The lower frame surface (44) and the lower substrate surface (28) are generally flush. The upper frame surface (42) lies above the upper substrate surface (27), to form a well (32), and the upper and lower frame surfaces (42,44) are continuously flat and generally parallel. The substrate is preferably glass having a thickness of 1.7 mm.Type: GrantFiled: May 29, 2015Date of Patent: October 19, 2021Assignee: LEICA MICROSYSTEMS CMS GMBHInventors: Paul C. Goodwin, Jeremy R. Cooper, Steven A. Reese, Kathryn Buckanan, Jeffrey D. Bert, James T. Newberry
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Patent number: 10067330Abstract: Methods and apparatus are described for delivering index-matching immersion liquid in high numerical-aperture optical microscopy and lithography. An array of immersion liquid droplets is delivered to a specimen substrate or specimen substrate cover by an immersion liquid printing apparatus. An immersion liquid reservoir provides immersion liquid to the printer by a precision pump. The printer delivers immersion liquid to the substrate or substrate cover in arrays of immersion liquid droplets of defined volumes and array patterns. The volumes and patterns of array droplets delivered to the substrate or substrate cover are optimized to maintain adequate immersion liquid between the substrate or substrate cover and an immersion objective while avoiding the formation of air bubbles in the immersion liquid and the accumulation of excess volumes of immersion liquid.Type: GrantFiled: June 7, 2016Date of Patent: September 4, 2018Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: William M. Dougherty, Paul C. Goodwin, Steven A. Reese, David A. Stewart
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Patent number: 9507136Abstract: Illumination system for a microscope system capable of being mode-switchable between a first and a second illumination mode, comprising one source of light for providing a collimated beam of light, at least one selector mirror capable of being positioned in at least two positions to redirect the beam of light in two different beam paths, the first beam path being a direct exit beam path wherein the selector mirror redirects the beam of light along an exit beam path to provide a first illumination mode, the second beam path is a mirror loop path comprising two or more mirrors arranged to redirect the beam of light onto the selector mirror such that it is redirected by the selector mirror a second time along the exit beam path, and wherein mirror loop path comprises at least one optical element arranged to optically alter the beam of light to provide the second illumination mode.Type: GrantFiled: November 14, 2012Date of Patent: November 29, 2016Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Jeremy R. Cooper, William M. Dougherty, Steven A. Reese
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Publication number: 20160282597Abstract: Methods and apparatus are described for delivering index-matching immersion liquid in high numerical-aperture optical microscopy and lithography. An array of immersion liquid droplets is delivered to a specimen substrate or specimen substrate cover by an immersion liquid printing apparatus. An immersion liquid reservoir provides immersion liquid to the printer by a precision pump. The printer delivers immersion liquid to the substrate or substrate cover in arrays of immersion liquid droplets of defined volumes and array patterns. The volumes and patterns of array droplets delivered to the substrate or substrate cover are optimized to maintain adequate immersion liquid between the substrate or substrate cover and an immersion objective while avoiding the formation of air bubbles in the immersion liquid and the accumulation of excess volumes of immersion liquid.Type: ApplicationFiled: June 7, 2016Publication date: September 29, 2016Inventors: William M. Dougherty, Paul C. Goodwin, Steven A. Reese, David A. Stewart
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Patent number: 9366851Abstract: Methods and apparatus are described for delivering index-matching immersion liquid in high numerical-aperture optical microscopy and lithography. An array of immersion liquid droplets is delivered to a specimen substrate or specimen substrate cover by an immersion liquid printing apparatus. An immersion liquid reservoir provides immersion liquid to the printer by a precision pump. The printer delivers immersion liquid to the substrate or substrate cover in arrays of immersion liquid droplets of defined volumes and array patterns. The volumes and patterns of array droplets delivered to the substrate or substrate cover are optimized to maintain adequate immersion liquid between the substrate or substrate cover and an immersion objective while avoiding the formation of air bubbles in the immersion liquid and the accumulation of excess volumes of immersion liquid.Type: GrantFiled: September 20, 2012Date of Patent: June 14, 2016Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: William M. Dougherty, Paul C. Goodwin, Steven A. Reese, David A. Stewart
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Patent number: 9256066Abstract: Irradiance control systems (“ICSs”) that control the irradiance of a beam of light are disclosed. ICSs include in a beam translator and a beam launch. The beam translator translates the beam substantially perpendicular to the propagating direction of the beam with a desired displacement so that the beam launch can remove a portion of the translated beam and the beam can be output with a desired irradiance. The beam launch attenuates the irradiance of the beam based on the amount by which the beam is translated. ISCs can be incorporated into fluorescent microscopy instruments to provide high-speed, fine-tune control over the irradiance of excitation beams.Type: GrantFiled: January 16, 2012Date of Patent: February 9, 2016Assignee: GE Healthcare Bio-Sciences Corp.Inventors: Jeremy R. Cooper, Steven A. Reese, William M. Dougherty
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Publication number: 20140320958Abstract: Illumination system for a microscope system capable of being mode-switchable between a first and a second illumination mode, comprising one source of light for providing a collimated beam of light, at least one selector mirror capable of being positioned in at least two positions to redirect the beam of light in two different beam paths, the first beam path being a direct exit beam path wherein the selector mirror redirects the beam of light along an exit beam path to provide a first illumination mode, the second beam path is a mirror loop path comprising two or more mirrors arranged to redirect the beam of light onto the selector mirror such that it is redirected by the selector mirror a second time along the exit beam path, and wherein mirror loop path comprises at least one optical element arranged to optically alter the beam of light to provide the second illumination mode.Type: ApplicationFiled: November 14, 2012Publication date: October 30, 2014Applicant: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Jeremy R. Cooper, William M. Dougherty, Steven A. Reese
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Patent number: 8115150Abstract: A new optical substrate design allows a target to be illuminated with minimal illumination of undesired surfaces within the image collection ray path.Type: GrantFiled: December 30, 2008Date of Patent: February 14, 2012Assignee: Applied Precision, Inc.Inventors: Carl S. Brown, Steven A. Reese
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Patent number: 7683345Abstract: A system and method employing photokinetic techniques in cell biology imaging applications are disclosed. Systems and methods of acquiring image data of an object may comprise: selectively inducing photoactivation of material at a site on the object; performing an optical axis integration scan; simultaneously executing a time delay integration scan sequence; and processing acquired image data in accordance with one or more desired analyses. Various methodologies and applications may include, inter alia, selective photobleaching of a site on the object, diffusion rate, velocity, and wave-front propagation analyses, multi-dimensional analyses of dispersion characteristics, biomolecular binding in cellular organelles, and photoactivation assisted systematic image segmentation for the study of cellular components.Type: GrantFiled: August 4, 2008Date of Patent: March 23, 2010Assignee: Applied Precision, Inc.Inventors: Paul C. Goodwin, Carl S. Brown, Steven A. Reese
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Patent number: 7608840Abstract: A system and method employing photokinetic techniques in cell biology imaging applications are disclosed. Systems and methods of acquiring image data of an object may comprise: selectively inducing photoactivation of material at a site on the object; performing an optical axis integration scan; simultaneously executing a time delay integration scan sequence; and processing acquired image data in accordance with one or more desired analyses. Various methodologies and applications may include, inter alia, selective photobleaching of a site on the object, diffusion rate, velocity, and wave-front propagation analyses, multi-dimensional analyses of dispersion characteristics, biomolecular binding in cellular organelles, and photoactivation assisted systematic image segmentation for the study of cellular components.Type: GrantFiled: August 4, 2008Date of Patent: October 27, 2009Assignee: Applied Precision, LLCInventors: Paul C. Goodwin, Carl S. Brown, Steven A. Reese
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Publication number: 20090206238Abstract: A new optical substrate design allows a target to be illuminated with minimal illumination of undesired surfaces within the image collection ray path.Type: ApplicationFiled: December 30, 2008Publication date: August 20, 2009Applicant: Applied Precision, Inc. Delaware corporationInventors: Carl S. Brown, Steven A. Reese
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Publication number: 20090109416Abstract: Methods and apparatus are described for delivering index-matching immersion liquid in high numerical-aperture optical microscopy and lithography. An array of immersion liquid droplets is delivered to a specimen substrate or specimen substrate cover by an immersion liquid printing apparatus. An immersion liquid reservoir provides immersion liquid to the printer by a precision pump. The printer delivers immersion liquid to the substrate or substrate cover in arrays of immersion liquid droplets of defined volumes and array patterns. The volumes and patterns of array droplets delivered to the substrate or substrate cover are optimized to maintain adequate immersion liquid between the substrate or substrate cover and an immersion objective while avoiding the formation of air bubbles in the immersion liquid and the accumulation of excess volumes of immersion liquid.Type: ApplicationFiled: September 11, 2008Publication date: April 30, 2009Applicant: APPLIED PRECISION, INC.Inventors: WILLIAM M. DOUGHERTY, Paul C. Goodwin, Steven A. Reese, David A. Stewart
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Publication number: 20090026386Abstract: A system and method employing photokinetic techniques in cell biology imaging applications are disclosed. Systems and methods of acquiring image data of an object may comprise: selectively inducing photoactivation of material at a site on the object; performing an optical axis integration scan; simultaneously executing a time delay integration scan sequence; and processing acquired image data in accordance with one or more desired analyses. Various methodologies and applications may include, inter alia, selective photobleaching of a site on the object, diffusion rate, velocity, and wave-front propagation analyses, multi-dimensional analyses of dispersion characteristics, biomolecular binding in cellular organelles, and photoactivation assisted systematic image segmentation for the study of cellular components.Type: ApplicationFiled: August 4, 2008Publication date: January 29, 2009Applicant: Applied Precision, LLCInventors: Paul C. Goodwin, Carl S. Brown, Steven A. Reese
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Publication number: 20090028413Abstract: A system and method employing photokinetic techniques in cell biology imaging applications are disclosed. Systems and methods of acquiring image data of an object may comprise: selectively inducing photoactivation of material at a site on the object; performing an optical axis integration scan; simultaneously executing a time delay integration scan sequence; and processing acquired image data in accordance with one or more desired analyses. Various methodologies and applications may include, inter alia, selective photobleaching of a site on the object, diffusion rate, velocity, and wave-front propagation analyses, multi-dimensional analyses of dispersion characteristics, biomolecular binding in cellular organelles, and photoactivation assisted systematic image segmentation for the study of cellular components.Type: ApplicationFiled: August 4, 2008Publication date: January 29, 2009Applicant: Applied Precision, LLCInventors: Paul C. Goodwin, Carl S. Brown, Steven A. Reese
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Patent number: 7408176Abstract: A system and method employing photokinetic techniques in cell biology imaging applications are disclosed. Systems and methods of acquiring image data of an object may comprise: selectively inducing photoactivation of material at a site on the object; performing an optical axis integration scan; simultaneously executing a time delay integration scan sequence; and processing acquired image data in accordance with one or more desired analyses. Various methodologies and applications may include, inter alia, selective photobleaching of a site on the object, diffusion rate, velocity, and wave-front propagation analyses, multi-dimensional analyses of dispersion characteristics, biomolecular binding in cellular organelles, and photoactivation assisted systematic image segmentation for the study of cellular components.Type: GrantFiled: June 18, 2004Date of Patent: August 5, 2008Assignee: Applied Precision, LLCInventors: Paul C. Goodwin, Carl S. Brown, Steven A. Reese
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Patent number: 7283253Abstract: An image acquisition system and method employing multi-axis integration (MAI) may incorporate both optical axis integration (OAI) and time-delay integration (TDI) techniques. Disclosed MAI systems and methods may integrate image data in the z direction as the data are acquired, projecting the image data prior to deconvolution. Lateral translation of the image plane during the scan in the z direction may allow large areas to be imaged in a single scan sequence.Type: GrantFiled: March 13, 2003Date of Patent: October 16, 2007Assignee: Applied Precision, LLCInventors: Steven A. Reese, Carl S. Brown, Paul C. Goodwin
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Publication number: 20040108641Abstract: A system and method of selectively fastening a substrate to a limited travel staging system are disclosed. In accordance with one aspect of a substrate holder, a securing mechanism may be manually or automatically moved in a repeatable manner such that a selected region of a substrate can be moved into the precision travel range of a highly accurate staging system. Some embodiments of a substrate holder may comprise an indexing system enabling referenced movements such that one or more selected substrate regions may be moved relative to the stage.Type: ApplicationFiled: September 5, 2003Publication date: June 10, 2004Inventors: Steven A. Reese, Peter C. Lombrozo, James A. Roecker, Paul C. Goodwin
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Publication number: 20030222197Abstract: An image acquisition system and method employing multi-axis integration (MAI) may incorporate both optical axis integration (OAI) and time-delay integration (TDI) techniques. Disclosed MAI systems and methods may integrate image data in the z direction as the data are acquired, projecting the image data prior to deconvolution. Lateral translation of the image plane during the scan in the z direction may allow large areas to be imaged in a single scan sequence.Type: ApplicationFiled: March 13, 2003Publication date: December 4, 2003Inventors: Steven A. Reese, Carl S. Brown, Paul C. Goodwin
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Publication number: 20020005493Abstract: The method of illumination of a microarray sample may contribute to the signal-to-background ratio. An oblique illumination technique is used to reduce the reflections from the sample to the detector. The sample may also be moved to the backside of the sample support to reduce the reflections caused by the sample support. In addition, a parallel scanning technique may be used to ensure proper alignment of the sample.Type: ApplicationFiled: April 4, 2001Publication date: January 17, 2002Inventors: Steven A. Reese, Steven C. Quarre, Carl S. Brown, Paul C. Goodwin