Abstract: The present invention provides methods, compositions, kits, systems and apparatus that are useful for isolating nucleic acid molecules from a sample. In particular, the methods generally relate to normalizing the concentration of target nucleic acid molecules from a sample. In one aspect, the invention relates to purifying a primer extension product from a primer extension reaction mixture. In some aspects, nucleic acid molecules obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing.

Abstract: The present invention provides methods, compositions, kits, systems and apparatus that are useful for isolating nucleic acid molecules from a sample. In particular, the methods generally relate to normalizing the concentration of target nucleic acid molecules from a sample. In one aspect, the invention relates to purifying a primer extension product from a primer extension reaction mixture. In some aspects, nucleic acid molecules obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing.

Abstract: The present invention provides methods, compositions, kits, systems and apparatus that are useful for isolating nucleic acid molecules from a sample. In particular, the methods generally relate to normalizing the concentration of target nucleic acid molecules from a sample. In one aspect, the invention relates to purifying a primer extension product from a primer extension reaction mixture. In some aspects, nucleic acid molecules obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing.

Abstract: The present invention provides methods, compositions, kits, systems and apparatus that are useful for isolating nucleic acid molecules from a sample. In particular, the methods generally relate to normalizing the concentration of target nucleic acid molecules from a sample. In one aspect, the invention relates to purifying a primer extension product from a primer extension reaction mixture. In some aspects, nucleic acid molecules obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing.

Abstract: The present invention provides methods, compositions, kits, systems and apparatus that are useful for isolating nucleic acid molecules from a sample. In particular, the methods generally relate to normalizing the concentration of target nucleic acid molecules from a sample. In one aspect, the invention relates to purifying a primer extension product from a primer extension reaction mixture. In some aspects, nucleic acid molecules obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing.

Abstract: The present invention provides methods, compositions, kits, systems and apparatus that are useful for isolating nucleic acid molecules from a sample. In particular, the methods generally relate to normalizing the concentration of target nucleic acid molecules from a sample. In one aspect, the invention relates to purifying a primer extension product from a primer extension reaction mixture. In some aspects, nucleic acid molecules obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing.

Abstract: The present invention provides methods, compositions, kits, systems and apparatus that are useful for isolating nucleic acid molecules from a sample. In particular, the methods generally relate to normalizing the concentration of target nucleic acid molecules from a sample. In one aspect, the invention relates to purifying a primer extension product from a primer extension reaction mixture. In some aspects, nucleic acid molecules obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing.

Abstract: The present invention provides methods, compositions, kits, systems and apparatus that are useful for isolating nucleic acid molecules from a sample. In particular, the methods generally relate to normalizing the concentration of target nucleic acid molecules from a sample. In one aspect, the invention relates to purifying a primer extension product from a primer extension reaction mixture. In some aspects, nucleic acid molecules obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing.

Abstract: The present invention relates to, in part, methods, reagents and apparatuses for the detection of agents. The present invention also relates, in part, to compositions including, but not limited to, flow cells, assay chambers, reagent reservoir delivery units and devices for holding an assay chamber. The present invention also provides various components and combinations of components for various detection apparatuses. The present invention also relates to a portable agent detection apparatus that can be used in the field or at a point of care and is not limited to specialized laboratories or limited to use by highly skilled users.

Abstract: The present invention relates to, in part, methods, reagents and apparatuses for the detection of agents. The present invention also relates, in part, to compositions including, but not limited to, flow cells, assay chambers, reagent reservoir delivery units and devices for holding an assay chamber. The present invention also provides various components and combinations of components for various detection apparatuses. The present invention also relates to a portable agent detection apparatus that can be used in the field or at a point of care and is not limited to specialized laboratories or limited to use by highly skilled users.

Abstract: A wheel end assembly for a vehicle includes an axle tube and a housing secured to the end of the axle tube. A hub includes a drive flange located axially outward from the housing and a spindle projecting from the drive flange into the housing. The hub spindle has a substantially solid body with drive splines about an external surface of the spindle. Rolling elements are located between the hub spindle and the housing for enabling the hub to rotate about an axis. The hub includes an inner race defining an inner raceway located around and carried by the hub spindle for engagement with the rolling elements. An axle shaft is positioned within the axle tube and includes splines that are coupled to the external drive splines of the hub. The axle shaft includes a substantially hollow end positioned within the housing having the shaft splines positioned within an inner surface of the hollow end of the axle shaft.

Abstract: A modeling and simulation apparatus and method for simulating a complex system includes linking together a plurality of computerized models. The models include at least one process model and one or more of a product model, information model and computer console emulator model. Communication clients for each model are connected to a communication server. The method includes transmitting a message from a communication client of a model to the communication server, the message including a class of information and a unique identifier corresponding to the class of information being transmitted; sorting messages received at the communication server into groups according to unique identifiers; queuing the messages within each group temporally; storing the grouped and queued messages at the communication server; and retrieving the transmitted message from the communication server using a second communication client of a second model.

Abstract: A wheel end assembly for a vehicle includes an axle tube and a housing secured to the end of the axle tube. A hub includes a drive flange located beyond the housing and a spindle projecting from the drive flange into the housing. The hub spindle has a substantially solid body with drive splines about an external surface of the spindle. Rolling elements are located between the hub spindle and the housing for enabling the hub to rotate about an axis. An axle shaft is positioned within the axle tube and includes splines that are coupled to the external drive splines of the hub.

Abstract: A solid axle for the driving wheels of an automotive vehicle has axle tubes through which axle shafts extend. Each tube at its outboard end is fitted with a wheel end, including a housing that is secured firmly to the tube, a hub having a drive flange located beyond the housing and a spindle that projects into the housing, and an antifriction bearing located between the housing and the hub spindle. Each axle shaft at its outboard end has a drive spindle that emerges from shoulder. The drive spindle projects through the hub at the end of its axle shaft and beyond the hub is deformed outwardly over a surface of the hub in the provision of a formed end, so that the hub is captured between the shoulder and the formed end, thus unifying the axle shaft and wheel end.

Abstract: An antifriction bearing A capable of transferring radial loads as well as thrust in both axial directions. The bearing A comprises an outer race (2) having a primary raceway (20) and a back face (22), the back face (22) further having a reverse thrust raceway (26) beyond the small end of the primary raceway (20). The bearing A also comprises an inner race (4) having another primary raceway (30). Rolling elements (6) are arranged in a single row between the primary raceways (20, 30) of the races (2, 4). A backing plate is carried by the inner race (4) and presented opposite the back face (2)2 of the outer race (2). An antifriction device (10) is located between the reverse thrust raceway (42) of the backing plate (8) and the reverse thrust raceway (26) of the outer race (2).

Abstract: An automotive vehicle has road wheels that are coupled to suspension uprights of the vehicle through wheel ends that have the capacity to monitor lateral loads that act on the road wheels at tire patches where the road wheels contact a road surface. Each wheel end offsets displacements that would be produced within the wheel end by vertical loads with displacements that would be produced by moments induced by the vertical loads, so that the remaining displacements within the wheel end reflect essentially lateral loads exerted at the tire patch. The wheel end contains a sensor and a target that the sensor monitors to detect the presence and magnitude of the displacements and hence the magnitude and direction of the lateral force at the tire patch. The sensor may also monitor angular velocity, angular position, and temperature.

Abstract: A hub assembly for coupling the road wheel of a vehicle to the suspension system of the vehicle includes a hub provided with a spindle, a housing surrounding the spindle of the hub, and an antifriction bearing located between the spindle and the housing. The bearing includes tapered rollers arranged in two rows as well as a pair tapered inner raceways carried by the spindle and a pair of tapered outer raceways carried by the housing. One of the tapered inner raceways is on a race that is initially separate from the housing, and this race has a recess that opens axially out of its end. The spindle has an integrally formed end that is received in the recess. The spindle and inner race may be engaged with splines and the inner race may further have an axial extension provided with an external spline that is selectively engaged by a connect-disconnect ring on a CV joint.

Abstract: Compounds of the formula ##STR1## wherein X is (--CR.sub.4 R.sub.4 --).sub.m in which m is 0 or 1;Y is (--CR.sub.5 R.sub.6 --).sub.n in which n is 0, 1 or 2;Z is (--CR.sub.7 R.sub.7 --).sub.p in which p is 1, 2, or 3; the sum of m+n+p is an integer of 2 to 5, inclusive;R.sub.2 and R.sub.3 each is H or alkyl, and the like;R.sub.1 is H or alkyl; andW is an unsaturated moiety, are useful as plant growth regulators and herbicides.

Abstract: Compounds of the formula ##STR1## wherein X is (--CR.sub.4 R.sub.4 --).sub.m in which m is 0 or 1;Y is (--CR.sub.5 R.sub.6 --).sub.n in which n is 0, 1 or 2;Z is (--CR.sub.7 R.sub.7 --).sub.p in which p is 1, 2 or 3;the sum of m+n+p is an integer of 2 to 5, inclusive;R.sub.2 and R.sub.3 each is H or alkyl, and the like;R.sub.1 is H or alkyl; andW is an unsaturated moiety, are useful as plant growth regulators and herbicides.

Abstract: Compounds of the formula ##STR1## wherein X is (--CR.sub.4 R.sub.4 --).sub.m in which m is 0 or 1;Y is (--CR.sub.5 R.sub.6 --).sub.n in which n is 0, 1 or 2;Z is (--CR.sub.7 R.sub.7 --).sub.p in which p is 1, 2 or 3;the sum of m+n+p is an integer of 2 to 5, inclusive;R.sub.2 and R.sub.3 each is H or alkyl, and the like;R.sub.1 is H or alkyl; andW is an unsaturated moiety, are useful as plant growth regulators and herbicides. Novel intermediates are also disclosed.