Abstract: A computer-implemented method for facilitating cardiac rehabilitation among eligible users is disclosed. The method includes the steps of (1) receiving health information associated with one or more users; (2) for each user of the one or more users: determining, based on health information associated with the user, a respective eligibility of the user for cardiac rehabilitation; (3) determining, based on the respective eligibilities, that at least one user of the one or more users is eligible for cardiac rehabilitation; (4) generating a treatment plan for the at least one user, where the treatment plan pertains to a cardiac rehabilitation that is specific to the at least one user; and (5) assigning the treatment plan to at least one electromechanical machine to enable the user to perform the cardiac rehabilitation.

Abstract: Systems, methods, and computer-readable media for assigning remote monitoring sessions. The system includes an electromechanical machine, one or more sensors, and one or more processing devices. The electromechanical machine is configured to be manipulated by a user while performing a treatment plan. The one or more sensors are configured to determine measurements of one or more vital signs associated with the user. The one or more processing devices are configured to receive a request to conduct a monitored session of the user performing the treatment plan. The one or more processing devices are also configured to determine whether conducting the monitored session with a computing device will violate one or more remote monitoring rules. The one or more processing device are further configured to initiate the monitored session by displaying the measurements on a display of the computing device while the user performs the treatment plan.

Abstract: A computer-implemented system includes an interface comprising a display configured to display interface presentation data pertaining to a user using an electromechanical machine to perform a treatment plan and one or more processing devices configured to receive selected measurement information associated with the user and treatment plan information associated with the treatment plan, generate the interface presentation data based on the selected measurement information and the treatment plan information, and enable the interface to present, in a portion of the display, the interface presentation data for the user. The portion of the display includes one or more graphical elements that present, in real-time or near real-time, at least one type of the selected measurement information and the treatment plan information.

Abstract: Disclosed is an isolated or purified T cell receptor (TCR), wherein the TCR has antigenic specificity for a mutated human RAS amino acid sequence with a substitution of glycine at position 13 with aspartic acid. The TCRs may recognize G13D RAS presented by an HLA-DQ heterodimer. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

Abstract: A computer-implemented system includes an interface comprising a display configured to display interface presentation data pertaining to a plurality of users each using a respective electromechanical machine to perform a treatment plan and one or more processing devices configured to receive selected measurement information associated with each of the plurality of users, generate the interface presentation data based on the selected measurement information; and enable the interface to present, in respective portions of the display, the interface presentation data for each of the plurality of users.

Abstract: A computer-implemented system includes one or more processing devices configured to receive attribute data associated with a user, generate, based on the attribute data and a first health issue of the user, a selected set of the attribute data, the first health issue corresponding to a first long-term care health issue of the user, determine, based on the selected set of the attribute data, a first probability associated with treating the first health issue, generate, based on the first probability, a treatment plan that includes one or more exercises directed to modifying the first probability, and modify, based on at least one of the first probability and a second probability, the treatment plan. The second probability is associated with treating a second health issue of the user. A treatment apparatus is configured to implement the treatment plan while the treatment apparatus is being manipulated by the user.

Abstract: A smart exercise device includes an interface comprising a smart mirror configured to present information pertaining to a treatment plan being performed by a user while the user interacts with the smart exercise device. A processing device is configured to cause the smart exercise device to perform one or more functions related to the treatment plan, such as cause one or more preventative actions to be performed based on whether the processing device receives one or more messages, cause one or more content items to be presented to the user on the interface, assign the treatment plan to the smart exercise device based on a determined eligibility of the user, and implement the treatment plan to reduce a probability of a cardiac intervention for the user.

Abstract: Computer-implemented systems, computer-implemented methods, and tangible, non-transitory computer-readable media for detecting abnormal heart rhythms of a user performing treatment plan with an electromechanical machine. The system includes, in one embodiment, an electromechanical machine, one or more sensors, and one or more processing devices. The electromechanical machine is configured to be manipulated by a user while the user is performing a treatment plan. The one or more sensors are configured to determine one or more measurements associated with the user. The one or more processing devices are configured to receive, from the one or more sensors while the user performs the treatment plan, the one or more measurements associated with the user. The one or more processing devices also configured to determine, using one or more machine learning models, a probability that the one or more measurements indicate that the user satisfies a threshold for a condition associated with an abnormal heart rhythm.

Abstract: A treadmill comprises a pair of rollers and a belt coupled to and extending between the pair of rollers. The belt encircles a support platform suspended between the pair of rollers. A motor is operatively coupled to one of the pair of rollers to rotate the one of the pair of rollers such that rotation of the rollers causes the belt to rotate around the support platform suspended between the pair of rollers. The treadmill further comprises a processing device configured to cause the treadmill to perform an action associated with a use of the treadmill by the user based on whether the processing device receives certain messages; cause content items to be presented to the user; assign the treatment plan to the treadmill based on a determined eligibility of the user; and implement the treatment plan to reduce a probability of a cardiac intervention for the user.

Abstract: The embodiments set forth a technique implemented by a computing device. The technique includes the steps of (1) receiving one or more characteristics associated with a user, wherein the one or more characteristics comprise personal information, performance information, measurement information, cohort information, familial information, comorbidity information, healthcare professional information, or some combination thereof; (2) determining, based on the one or more characteristics, one or more conditions of the user, wherein the one or more conditions pertain to cardiac health, pulmonary health, bariatric health, oncologic health, cardio-oncologic health, or some combination thereof; (3) based on the one or more conditions, identifying, using one or more trained machine learning models, one or more subgroups to present via the display, wherein the one or more subgroups represent different partitions of the one or more characteristics; and (4) presenting, via the display, the one or more subgroups.

Abstract: Disclosed is a T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of human papillomavirus (HPV) 16 E6, E629-38. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of a condition in a mammal and methods of treating or preventing a condition in a mammal, wherein the condition is cancer, HPV 16 infection, or HPV-positive premalignancy.

Abstract: A computer-implemented method including receiving, at a computing device, a first treatment plan designed to treat a sexual performance health issue of a user. The first treatment plan comprises at least two exercise sessions that, based on the sexual performance health issue, enable the user to perform an exercise at different exertion levels. While the user uses a treatment apparatus to perform the first treatment plan for the user, the computing device receives cardiovascular data from one or more sensors configured to measure the cardiovascular data associated with the user, and transmits the cardiovascular data. A machine learning model is used to generate a second treatment plan that modifies at least one exertion level, and the modification is based on a standardized measure comprising perceived exertion, the cardiovascular data, and the cardiovascular health issue of the user. The method includes receiving the second treatment plan.

Abstract: A computer-implemented system includes one or more processing devices configured to receive attribute data associated with a user, generate, based on a pulmonary condition of the user, a selected set of the attribute data, determine, based on the selected set of the attribute data, a first probability of improving a pulmonary condition of the user subsequent to at least one of a pulmonary procedure being performed on the user, a pulmonary treatment being performed on the user, and a pulmonary diagnosis, and generate, based on the first probability, a treatment plan that includes one or more exercises directed to modifying the first probability. A treatment apparatus is configured to enable implementation of the treatment plan.

Abstract: Disclosed are isolated or purified T cell receptors (TCRs) having antigenic specificity for human p53R273C or human p53Y220C. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

Abstract: The invention provides methods of increasing the efficacy of a T cell therapy in a patient in need thereof. The invention includes methods of identifying a patient who would respond well to a T cell therapy or conditioning a patient prior to a T cell therapy so that the patient responds well to a T cell therapy. The conditioning involves administering one or more preconditioning agents prior to a T cell therapy and identifying biomarker cytokines prior to administering a T cell therapy.

Abstract: A computer-implemented system includes one or more processing devices configured to receive attribute data associated with a user, generate, based on at least one of a first bariatric procedure to be performed on the user and a second bariatric procedure already performed on the user, a selected set of the attribute data, determine, based on the selected set of the attribute data, at least one of a first probability of being eligible for the first bariatric procedure to be performed on the user and a second probability of improving a bariatric condition of the user subsequent to the second bariatric procedure being performed on the user, and generate, based on the at least one of the first probability and the second probability, a treatment plan that includes one or more exercises directed to modifying the at least one of the first probability and the second probability, and a treatment apparatus configured for implementation of the treatment plan.

Abstract: Disclosed are methods of isolating T cells and TCRs having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation. Also disclosed are related methods of preparing a population of cells, populations of cells, TCRs, pharmaceutical compositions, and methods of treating or preventing cancer.

Abstract: A computer-implemented system includes one or more processing devices configured to receive comorbidity information that includes a plurality of comorbidities or comorbidity-related conditions associated with a user, generate a selected set of the comorbidity information, determine, based on the selected set of the comorbidity information, respective probabilities of a plurality of different outcomes related to the comorbidity information, and generate, based on the respective probabilities and the selected set of the comorbidity information, a treatment plan comprising one or more exercises directed to changing the respective probabilities. A treatment apparatus is configured to implement the treatment plan while the treatment apparatus is being manipulated by the user.

Abstract: A computer-implemented system includes one or more processing devices configured to receive user information associated with a user, generate a selected set of the user information, determine, based on the selected set of the user information, at least one of a first probability of surviving one or more procedures and a second probability indicating an improvement, resulting from the one or more procedures, in quality-of-life metrics for the user, generate, based on the at least one of the first probability and the second probability and on the selected set of the user information, one or more recommendations of whether the user should undergo the one or more procedures, and generate, based on the one or more recommendations, a treatment plan that includes one or more exercises directed to modifying the at least one of the first probability and the second probability.