Patents by Inventor Steven A. Smith

Steven A. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FOOTWEAR WITH MULTI-MATERIAL OUTSOLE
    Publication number: 20240228775
    Abstract: A footwear article comprises: an outsole comprising: an outsole body comprising a first polyurethane polymeric material attached to one or more tread cleats comprising a nitrile butadiene rubber polymeric material; and a footwear upper affixed to the outsole, the footwear upper comprising a second polyurethane polymeric material. Footwear articles, including boots, overshoes, and/or work shoes, are effective to meet or exceed slip resistance in accordance with ASTM F3445-21. Methods of making the footwear articles are also described.
    Type: Application
    Filed: October 16, 2023
    Publication date: July 11, 2024
    Applicant: Tingley Rubber Corporation
    Inventors: James P. Towey, Robert N. Petersen, Steven A. Smith, Timothy L. Cullen
  • FOOTWEAR WITH MULTI-MATERIAL OUTSOLE
    Publication number: 20240132720
    Abstract: A footwear article comprises: an outsole comprising: an outsole body comprising a first polyurethane polymeric material attached to one or more tread cleats comprising a nitrile butadiene rubber polymeric material; and a footwear upper affixed to the outsole, the footwear upper comprising a second polyurethane polymeric material. Footwear articles, including boots, overshoes, and/or work shoes, are effective to meet or exceed slip resistance in accordance with ASTM F3445-21. Methods of making the footwear articles are also described.
    Type: Application
    Filed: October 15, 2023
    Publication date: April 25, 2024
    Applicant: Tingley Rubber Corporation
    Inventors: James P. Towey, Robert N. Petersen, Steven A. Smith, Timothy L. Cullen
  • Prodrugs of fencamfamine
    Patent number: 11919836
    Abstract: Disclosed herein are pharmaceutical compositions comprising fencamfamine or fencamfamine related prodrug derivatives for targeted therapeutic applications and methods of synthesizing the compositions.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: March 5, 2024
    Assignee: Praxis Bioresearch, LLC
    Inventors: Sandeep Patil, Ron Bihovsky, Steven A Smith, Yuhua Ji, Valentino Stella, Daniel D. Long, Daniel Marquess
  • Prodrugs of fencamfamine
    Patent number: 11731935
    Abstract: Disclosed herein are pharmaceutical compositions comprising fencamfamine or fencamfamine related prodrug derivatives for targeted therapeutic applications and methods of synthesizing the compositions.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: August 22, 2023
    Assignee: Praxis Bioresearch, LLC
    Inventors: Sandeep Patil, Ron Bihovsky, Steven A Smith, Yuhua Ji, Valentino Stella, Daniel D. Long, Daniel Marquess
  • CANCER TREATMENT METHODS
    Publication number: 20230165968
    Abstract: The invention provides methods for treating cancer in a subject comprising administering an immunoconjugate of formula: Ab-[TA]r or a pharmaceutically acceptable salt thereof, wherein “Ab” is an antibody construct that has an antigen binding domain that binds human epidermal growth factor receptor type 2 (HER2) and “TA” is a therapeutic agent of formula: wherein n is from about 2 to about 25 and r is an average therapeutic agent to antibody ratio from 1 to 10, to a subject having cancer.
    Type: Application
    Filed: February 25, 2021
    Publication date: June 1, 2023
    Applicant: BOLT BIOTHERAPEUTICS, INC.
    Inventors: Shelley Erin ACKERMAN, Michael N. ALONSO, David DORNAN, Marcin L. KOWANETZ, Robert S. SIKORSKI, Steven A. SMITH
  • COMBINATIONS OF MENIN INHIBITORS AND CYP3A4 INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20230165858
    Abstract: The present invention is directed to combinations of menin inhibitors with one or more CYP3A4 inhibitors, pharmaceutical compositions thereof, and methods of treating cancer and other diseases mediated by the menin-MLL interaction.
    Type: Application
    Filed: April 7, 2021
    Publication date: June 1, 2023
    Inventors: Gerard M. MCGEEHAN, Peter ORDENTLICH, Galit ROSEN, Steven A. SMITH
  • BOOTS WITH GUSSET
    Publication number: 20230157414
    Abstract: A boot comprises: an outsole and a polymeric upper affixed to the outsole. The upper comprises an upper body and a gusset, which comprises a relaxed position and an expanded position, wherein the gusset moves from the relaxed position to the expanded position to accommodate a wearer's leg upon donning of the boot.
    Type: Application
    Filed: January 23, 2023
    Publication date: May 25, 2023
    Applicant: Tingley Rubber Corporation
    Inventors: James P. Towey, Steven A. Smith, Robert N. Petersen
  • Liquid formulations of (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a] pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
    Patent number: 11484535
    Abstract: A liquid formulation of (S)—N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide, pharmaceutically acceptable salts thereof, or a combination thereof and the use of the liquid formulation in the treatment of pain, cancer, inflammation, and certain infectious diseases are disclosed.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: November 1, 2022
    Assignee: Loxo Oncology, Inc.
    Inventors: Mark Reynolds, Steven A Smith
  • Crystalline salts and polymorphs of a P2X3 antagonist
    Patent number: 11230533
    Abstract: Provided are novel salts and polymorphs of 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonamide, which are potentially useful for modulating a condition mediated by a P2X3 or P2X2/3 receptor. Also provided are pharmaceutical formulations and methods of administration and dosing of these salts and polymorphs to subjects in need thereof.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: January 25, 2022
    Assignee: AFFERENT PHARMACEUTICALS, INC.
    Inventors: Prabha Ibrahim, Ronald Charles Hawley, Anthony P. Ford, Steven A. Smith
  • Boots with polymeric foam shell and exposed sock liner
    Patent number: 11172725
    Abstract: A boot comprises: a shell comprising a first foamed polymeric material; a sock liner comprising a second foamed polymeric material, the sock liner having an exposed section and an enclosed section; and an adhesive layer affixing the shell and the enclosed section of the sock liner; wherein there is an absence of intermingling of the second surface of the enclosed section of the sock liner with the inner surface of the shell. Methods of making and using the boot are also provided.
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: November 16, 2021
    Assignee: Tingley Rubber Corporation
    Inventors: Robert N. Petersen, Steven A. Smith, James P. Towey, Michael S. Zedalis
  • PRODRUGS OF FENCAMFAMINE
    Publication number: 20200399203
    Abstract: Disclosed herein are pharmaceutical compositions comprising fencamfamine or fencamfamine related prodrug derivatives for targeted therapeutic applications and methods of synthesizing the compositions.
    Type: Application
    Filed: April 14, 2020
    Publication date: December 24, 2020
    Inventors: Sandeep Patil, Ron Bihovsky, Steven A. Smith, Yuhua Ji, Valentino Stella, Daniel D. Long, Daniel Marquess
  • Polyvinyl chloride safety boots
    Patent number: 10856605
    Abstract: A boot comprises: an outsole and an upper affixed to the outsole, the upper comprising a polyvinyl chloride (PVC) upper body and a composite toe cap. The composite toe cap comprises a fiberglass reinforced polymer, and the composite toe cap comprises a tapered surface.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: December 8, 2020
    Assignee: Tingley Rubber Corporation
    Inventors: Steven A. Smith, James P. Towey, Robert N. Petersen, Wang Sheng Ming
  • LIQUID FORMULATIONS OF (S)-N-(5-((R)-2-(2,5-DIFLUOROPHENYL)-PYRROLIDIN-1-YL)-PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)-3-HYDROXYPYRROLIDINE-1-CARBOXAMIDE
    Publication number: 20200338079
    Abstract: A liquid formulation of (S)—N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide, pharmaceutically acceptable salts thereof, or a combination thereof and the use of the liquid formulation in the treatment of pain, cancer, inflammation, and certain infectious diseases are disclosed.
    Type: Application
    Filed: April 27, 2020
    Publication date: October 29, 2020
    Inventors: Mark Reynolds, Steven A Smith
  • CRYSTALLINE SALTS AND POLYMORPHS OF A P2X3 ANTAGONIST
    Publication number: 20200255386
    Abstract: Provided are novel salts and polymorphs of 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonamide, which are potentially useful for modulating a condition mediated by a P2X3 or P2X2/3 receptor. Also provided are pharmaceutical formulations and methods of administration and dosing of these salts and polymorphs to subjects in need thereof.
    Type: Application
    Filed: April 30, 2020
    Publication date: August 13, 2020
    Applicant: Afferent Pharmaceuticals, Inc.
    Inventors: Prabha Ibrahim, Ronald Charles Hawley, Anthony P. Ford, Steven A. Smith
  • Crystalline salts and polymorphs of a P2X3 antagonist
    Patent number: 10676444
    Abstract: Provided are novel salts and polymorphs of 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonamide, which are potentially useful for modulating a condition mediated by a P2X3 or P2X2/3 receptor. Also provided are pharmaceutical formulations and methods of administration and dosing of these salts and polymorphs to subjects in need thereof.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: June 9, 2020
    Assignee: Afferent Pharmaceuticals, Inc.
    Inventors: Prabha Ibrahim, Ronald Charles Hawley, Anthony P. Ford, Steven A. Smith
  • Liquid formulations of (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
    Patent number: 10668072
    Abstract: A liquid formulation of (S)—N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide, pharmaceutically acceptable salts thereof, or a combination thereof and the use of the liquid formulation in the treatment of pain, cancer, inflammation, and certain infectious diseases are disclosed.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: June 2, 2020
    Assignee: Loxo Oncology, Inc.
    Inventors: Mark Reynolds, Steven A. Smith
  • Prodrugs of fencamfamine
    Patent number: 10662146
    Abstract: Disclosed herein are pharmaceutical compositions with fencamfamine or fencamfamine related prodrug derivatives. The pharmaceutical compositions are for targeted therapeutic applications including, but not limited to, treating cancer-related fatigue, apathy in Alzheimer's Disease, major depression, and attention deficit-hyperactivity disorder. Also disclosed are methods of synthesizing the pharmaceutical compositions with fencamfamine or fencamfamine related prodrug derivatives.
    Type: Grant
    Filed: September 13, 2016
    Date of Patent: May 26, 2020
    Assignee: PRAXIS BIORESEARCH, LLC
    Inventors: Sandeep Patil, Ron Bihovsky, Steven A. Smith, Yuhua Ji, Valentino Stella, Daniel D. Long, Daniel Marquess
  • Boots With Polymeric Foam Shell And Exposed Sock Liner
    Publication number: 20200113270
    Abstract: A boot comprises: a shell comprising a first foamed polymeric material; a sock liner comprising a second foamed polymeric material, the sock liner having an exposed section and an enclosed section; and an adhesive layer affixing the shell and the enclosed section of the sock liner; wherein there is an absence of intermingling of the second surface of the enclosed section of the sock liner with the inner surface of the shell. Methods of making and using the boot are also provided.
    Type: Application
    Filed: October 9, 2019
    Publication date: April 16, 2020
    Inventors: Robert N. Petersen, Steven A. Smith, James P. Towey, Michael S. Zedalis
  • CRYSTALLINE SALTS AND POLYMORPHS OF A P2X3 ANTAGONIST
    Publication number: 20190315698
    Abstract: Provided are novel salts and polymorphs of 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonamide, which are potentially useful for modulating a condition mediated by a P2X3 or P2X2/3 receptor. Also provided are pharmaceutical formulations and methods of administration and dosing of these salts and polymorphs to subjects in need thereof.
    Type: Application
    Filed: December 15, 2017
    Publication date: October 17, 2019
    Applicant: Afferent Pharmaceuticals, Inc.
    Inventors: Prabha Ibrahim, Ronald Charles Hawley, Anthony P. Ford, Steven A. Smith
  • LIQUID FORMULATIONS OF (S)-N-(5-((R)-2-(2,5-DIFLUOROPHENYL)-PYRROLIDIN-1-YL)-PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)-3-HYDROXYPYRROLIDINE-1-CARBOXAMIDE
    Publication number: 20190216814
    Abstract: A liquid formulation of (S)—N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide, pharmaceutically acceptable salts thereof, or a combination thereof and the use of the liquid formulation in the treatment of pain, cancer, inflammation, and certain infectious diseases are disclosed.
    Type: Application
    Filed: November 26, 2018
    Publication date: July 18, 2019
    Inventors: Mark Reynolds, Steven A. Smith