Patents by Inventor Steven A. Weissman

Steven A. Weissman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR PREPARING AN ENANTIOMERICALLY ENRICHED, DEUTERATED SECONDARY ALCOHOL FROM A CORRESPONDING KETONE WITHOUT REDUCING DEUTERIUM INCORPORATION
    Publication number: 20150376665
    Abstract: The present invention provides a process for the preparation of enantiomerically enriched, deuterated secondary alcohols of Formula 1-A by employing ketoreductases or carbonyl reductases without reducing deuterium incorporation.
    Type: Application
    Filed: July 1, 2015
    Publication date: December 31, 2015
    Inventors: Ramanaiah C. Kanamarlapudi, Steven A. Weissman, Emerich Eisenreich, Xuejun Liu
  • Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
    Patent number: 9085788
    Abstract: The present invention provides a convenient and efficient process for the preparation of enantiomerically enriched, deuterated secondary alcohols without reducing deuterium incorporation.
    Type: Grant
    Filed: September 1, 2011
    Date of Patent: July 21, 2015
    Assignee: Concert Pharmaceuticals, Inc.
    Inventors: Ramanaiah C. Kanamarlapudi, Steven A. Weissman, Emerich Eisenreich, Xuejun Liu
  • Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
    Patent number: 9074233
    Abstract: The present invention provides a process for the preparation of enantiomerically enriched, deuterated secondary alcohols of Formula 1-A by employing ketoreductases or carbonyl reductases without reducing deuterium incorporation.
    Type: Grant
    Filed: September 1, 2011
    Date of Patent: July 7, 2015
    Assignee: Concert Pharmaceuticals, Inc.
    Inventors: Ramanaiah C. Kanamarlapudi, Steven A. Weissman, Emerich Eisenreich, Xuejun Liu
  • PROCESS FOR PREPARING AN ENANTIOMERICALLY ENRICHED, DEUTERATED SECONDARY ALCOHOL FROM A CORRESPONDING KETONE WITHOUT REDUCING DEUTERIUM INCORPORATION
    Publication number: 20140017739
    Abstract: The present invention provides a convenient and efficient process for the preparation of enantiomerically enriched, deuterated secondary alcohols without reducing deuterium incorporation.
    Type: Application
    Filed: September 1, 2011
    Publication date: January 16, 2014
    Applicant: CONCERT PHARMACEUTICALS, INC.
    Inventors: Ramanaiah C. Kanamarlapudi, Steven A. Weissman, Emerich Eisenreich, Xuejun Liu
  • PROCESS FOR PREPARING AN ENANTIOMERICALLY ENRICHED, DEUTERATED SECONDARY ALCOHOL FROM A CORRESPONDING KETONE WITHOUT REDUCING DEUTERIUM INCORPORATION
    Publication number: 20130280768
    Abstract: The present invention provides a process for the preparation of enantiomerically enriched, deuterated secondary alcohols of Formula 1-A by employing ketoreductases or carbonyl reductases without reducing deuterium incorporation.
    Type: Application
    Filed: September 1, 2011
    Publication date: October 24, 2013
    Applicant: CONCERT PHARMACEUTICALS, INC.
    Inventors: Ramanaiah C. Kanamarlapudi, Steven A. Weissman, Emerich Eisenreich, Xuejun Liu
  • Synthesis and crystalline forms of NPY5 antagonist
    Patent number: 7700611
    Abstract: The present invention relates to a process for producing crystalline trans-N-[1-(2-fluorophenyl)-S-pyrazoly]-3-ox-ospiro[6-azaisobenzofuran-1(3H),1?-cyclohexane]-4?-carboxamide and novel salts, hydrates and polymorphs thereof.
    Type: Grant
    Filed: July 24, 2006
    Date of Patent: April 20, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Russell R. Ferlita, Yuji Haga, Makoto Ishikawa, Keisuke Kamei, Shinji Kato, Hisaki Kojima, Aaron Moment, Nobuaki Nonoyama, Nobuya Satake, Kazuki Shigemori, Toshihiro Wada, Yaling Wang, Steven A. Weissman, Robert M. Wenslow
  • Cyanation of aromatic halides
    Patent number: 7595417
    Abstract: A practical, ligand-free cyanation of aryl bromides employs Pd catalyst in combination with a non-toxic cyanide source, Mn[Fe(CN)6] (M=K or Na; n is 3 or 4), or a hydrate thereof, and a base. The reactions are performed in a polar aprotic solvents and provide the corresponding aryl nitrile in 83-96% yield, typically in less than 5 h.
    Type: Grant
    Filed: November 14, 2005
    Date of Patent: September 29, 2009
    Assignee: Merck & Co., Inc.
    Inventor: Steven A. Weissman
  • Synthesis and Crystalline Forms of Npy5 Antagonist
    Publication number: 20090124648
    Abstract: The present invention relates to a process for producing crystalline trans-N-[1-(2-fluorophenyl)-S-pyrazoly]-3-ox-ospiro[6-azaisobenzofuran-1(3H),1?-cyclohexane]-4?-carboxamide and novel salts, hydrates and polymorphs thereof.
    Type: Application
    Filed: July 24, 2006
    Publication date: May 14, 2009
    Inventors: Russell R. Ferlita, Yuji Haga, Makoto Ishikawa, Keisuke Kamei, Shinji Kato, Hisaki Kojima, Aaron Moment, Nobuaki Nonoyama, Nobuya Satake, Kazuki Shigemori, Toshihiro Wada, Yaling Wang, Steven A. Weissman, Robert M. Wenslow
  • Process for making spirolactone compounds
    Patent number: 7482449
    Abstract: This invention relates to a process for making spirolactone compounds analogous to formula I.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: January 27, 2009
    Assignees: Merck & Co., Inc., Banyu Pharmaceutical Co., Ltd.
    Inventors: Ralph P. Volante, David M. Tschaen, Steven A. Weissman, Matthew Heileman, Toshiaki Mase, Takehiko Iida, Kenji Maeda, Toshihiro Wada, Hiroki Sato, Kenichi Asakawa
  • Process for making spirolactone compounds
    Publication number: 20080171888
    Abstract: This invention relates to a process for making spirolactone compounds analogous to formula I.
    Type: Application
    Filed: March 19, 2008
    Publication date: July 17, 2008
    Inventors: Ralph P. Volante, David M. Tschaen, Steven A. Weissman, Matthew Heileman, Toshiaki Mase, Takehiko Iida, Kenji Maeda, Toshihiro Wada, Hiroki Sato, Kenichi Asakawa
  • Process for making spirolactone compounds
    Patent number: 7368569
    Abstract: This invention relates to a process for making spirolactone compounds analogous to formula I
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: May 6, 2008
    Assignees: Merck & Co., Inc., Banyu Pharmaceutical Co., Ltd.
    Inventors: Ralph P. Volante, David M. Tschaen, Steven A. Weissman, Matthew Heileman, Toshiaki Mase, Takehiko Iida, Kenji Maeda, Toshihiro Wada, Hiroki Sato, Kenichi Asakawa
  • Phase transfer catalyzed glycosidation of an indolocarbazole
    Publication number: 20040024196
    Abstract: The present invention relates to a novel glycosidation process to make intermediates useful in the preparation of indolopyrrolocarbazole derivatives which inhibit the growth of tumor cells and are therefore useful in the treatment of cancer in mammals, and the like.
    Type: Application
    Filed: July 31, 2003
    Publication date: February 5, 2004
    Inventors: Daniel E Petrillo, Steven A. Weissman, Shouichi Hiraga, Nobuya Satake, Kai Rossen
  • Phase transfer catalyzed glycosidation of an indolocarbazole
    Patent number: 6555677
    Abstract: The present invention relates to a novel glycosidation process to make intermediates useful in the preparation of indolopyrrolocarbazole derivatives which inhibit the growth of tumor cells and are therefore useful in the treatment of cancer in mammals, and the like.
    Type: Grant
    Filed: October 22, 2001
    Date of Patent: April 29, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Daniel E. Petrillo, Steven A. Weissman, Shouichi Hiraga, Nobuya Satake, Kai Rossen
  • Phase transfer catalyzed glycosidation of an indolocarbazole
    Publication number: 20020058803
    Abstract: The present invention relates to a novel glycosidation process to make intermediates useful in the preparation of indolopyrrolocarbazole derivatives which inhibit the growth of tumor cells and are therefore useful in the treatment of cancer in mammals, and the like.
    Type: Application
    Filed: October 22, 2001
    Publication date: May 16, 2002
    Inventors: Daniel E. Petrillo, Steven A. Weissman, Shouichi Hiraga, Nobuya Satake, Kai Rossen
  • Process for preparing &bgr;-hydroxycarbamates and their conversion to oxazolidinones
    Patent number: 6372911
    Abstract: A process for preparing a &bgr;-hydroxy carbamate product is disclosed. The process comprises reacting an olefin compound containing at least one carbon-carbon double bond with a carbamate in an aqueous solvent and in the presence of a base, an osmium catalyst, a co-oxidant selected from a halohydantoin, a haloisocyanuric acid, and an alkali metal salt of a haloisocyanuric acid, and optionally an asymmetric ligand, to form a reaction mixture containing the &bgr;-hydroxy carbamate product. The process optionally further comprises treating the &bgr;-hydroxy carbamate product with additional base to form an oxazolidinone. The oxazolidinones are useful as chiral auxiliary agents and as intermediates for the formation of pharmaceutically active substances such as alpha 1 a adrenergic receptor antagonists. A process for preparing nitrogen-functionalized derivatives of the oxazolidinones is also disclosed.
    Type: Grant
    Filed: January 13, 2000
    Date of Patent: April 16, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Nancy Barta, Robert D. Larsen, Daniel R. Sidler, Steven A. Weissman
  • Process for the synthesis of substituted piperazinones via Mitsunobu reaction
    Patent number: 6160118
    Abstract: The present invention is directed to a process for synthesizing substituted piperazinones, which are useful intermediates for making farnesyl-protein transferase inhibitors, using a Mitsunobu reaction.
    Type: Grant
    Filed: June 23, 1999
    Date of Patent: December 12, 2000
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Stephanie Lewis, Steven A. Weissman
  • Process for making an epoxide
    Patent number: 5728840
    Abstract: A process for synthesizing the epoxide of the formula ##STR1## consists of, at a minimum, formation of a halohydrin from the allyl acetonide reactat, followed by base-induced cyclization, the epoxide product I being useful as an intermediate for the synthesis of inhibitors of renin or HIV protease or other proteases.
    Type: Grant
    Filed: August 8, 1995
    Date of Patent: March 17, 1998
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Kan K. Eng, Peter E. Maligres, Paul J. Reider, Kai Rossen, Ralph P. Volante, Veena Upadhyay, Steven A. Weissman
  • Process for preparing 4-tert-butyloxycarbonyl-(S)-piperazine-2-tert-butylcarboxamide
    Patent number: 5723615
    Abstract: An improved process using chiral hydrogenation is described for the synthesis in high yields of a 4-protected-(S)-piperazine-2-tert-butyl-carboxamide, an intermediate for an HIV protease inhibitor.
    Type: Grant
    Filed: June 18, 1996
    Date of Patent: March 3, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Kai Rossen, Steven A. Weissman, Jess Sager, David Askin, Paul J. Reider, Ralph P. Volante
  • Process for aromatic bromination
    Patent number: 5248817
    Abstract: A novel procedure for bromination of aromatic moieties utilizes N-bromosuccinimide or dibromodimethylhydantoin in an aqueous alkali medium. The bromination procedure is employed for the preparation of an intermediate used in the preparation of remoxipride, an antipsychotic compound.
    Type: Grant
    Filed: July 8, 1992
    Date of Patent: September 28, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Joseph Auerbach, Steven A. Weissman