Patents by Inventor Steven A. Weissman

Steven A. Weissman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Procedure for the preparation of 4-phenyl butyrate and uses thereof
    Patent number: 11014870
    Abstract: Provided is a process for preparing 4-phenyl-1-butyric acid, comprising: reacting 4-phenyl-1-butanol with sodium chlorite, a nitroxyl radical catalyst and sodium hypochlorite in an organic solvent and a phosphate buffer; and quenching the reaction with sodium sulfite to produce 4-phenyl-1-butyric. Also provided is 4-phenyl-1-butyric acid prepared by such a process.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: May 25, 2021
    Assignee: Horizon Therapeutics, LLC
    Inventors: Huai-Chueh Chang, Steven S. Pfeiffer, Vasilios H. Iskos, Maki Uragami, Steven Weissman, Andrew Thompson
  • PROCEDURE FOR THE PREPARATION OF 4-PHENYL BUTYRATE AND USES THEREOF
    Publication number: 20200002266
    Abstract: Provided is a process for preparing 4-phenyl-1-butyric acid, comprising: reacting 4-phenyl-1-butanol with sodium chlorite, a nitroxyl radical catalyst and sodium hypochlorite in an organic solvent and a phosphate buffer; and quenching the reaction with sodium sulfite to produce 4-phenyl-1-butyric. Also provided is 4-phenyl-1-butyric acid prepared by such a process.
    Type: Application
    Filed: May 7, 2019
    Publication date: January 2, 2020
    Inventors: Huai-Chueh CHANG, Steven S. PFEIFFER, Vasilios H. ISKOS, Maki URAGAMI, Steven WEISSMAN, Andrew THOMPSON
  • Procedure for the preparation of 4-phenyl butyrate and uses thereof
    Patent number: 10329236
    Abstract: Provided is a process for preparing 4-phenyl-1-butyric acid, comprising: reacting 4-phenyl-1-butanol with sodium chlorite, a nitroxyl radical catalyst and sodium hypochlorite in an organic solvent and a phosphate buffer; and quenching the reaction with sodium sulfite to produce 4-phenyl-1-butyric. Also provided is 4-phenyl-1-butyric acid prepared by such a process.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: June 25, 2019
    Assignee: Horizon Therapeutics, LLC
    Inventors: Huai-Chueh Chang, Steven S. Pfeiffer, Vasilios H. Iskos, Maki Uragami, Steven Weissman, Andrew Thompson
  • Procedure for the preparation of 4-phenyl butyrate and uses thereof
    Patent number: 9914692
    Abstract: Provided is a process for preparing 4-phenyl-1-butyric acid, comprising: reacting 4-phenyl-1-butanol with sodium chlorite, a nitroxyl radical catalyst and sodium hypochlorite in an organic solvent and a phosphate buffer; and quenching the reaction with sodium sulfite to produce 4-phenyl-1-butyric. Also provided is 4-phenyl-1-butyric acid prepared by such a process.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: March 13, 2018
    Assignee: Horizon Therapeutics, LLC
    Inventors: Huai-Chueh Chang, Steven S. Pfeiffer, Vasilios H. Iskos, Maki Uragami, Steven Weissman, Andrew Thompson
  • PROCEDURE FOR THE PREPARATION OF 4-PHENYL BUTYRATE AND USES THEREOF
    Publication number: 20170362160
    Abstract: Provided is a process for preparing 4-phenyl-1-butyric acid, comprising: reacting 4-phenyl-1-butanol with sodium chlorite, a nitroxyl radical catalyst and sodium hypochlorite in an organic solvent and a phosphate buffer; and quenching the reaction with sodium sulfite to produce 4-phenyl-1-butyric. Also provided is 4-phenyl-1-butyric acid prepared by such a process.
    Type: Application
    Filed: September 6, 2017
    Publication date: December 21, 2017
    Inventors: Huai-Chueh CHANG, Steven S. PFEIFFER, Vasilios H. ISKOS, Maki URAGAMI, Steven WEISSMAN, Andrew THOMPSON
  • PROCEDURE FOR THE PREPARATION OF 4-PHENYL BUTYRATE AND USES THEREOF
    Publication number: 20170342018
    Abstract: Provided is a process for preparing 4-phenyl-1-butyric acid, comprising: reacting 4-phenyl-1-butanol with sodium chlorite, a nitroxyl radical catalyst and sodium hypochlorite in an organic solvent and a phosphate buffer; and quenching the reaction with sodium sulfite to produce 4-phenyl-1-butyric. Also provided is 4-phenyl-1-butyric acid prepared by such a process.
    Type: Application
    Filed: May 25, 2016
    Publication date: November 30, 2017
    Inventors: Huai-Chueh Chang, Steven S. Pfeiffer, Vasilios H. Iskos, Maki Uragami, Steven Weissman, Andrew Thompson
  • PROCESS FOR PREPARING AN ENANTIOMERICALLY ENRICHED, DEUTERATED SECONDARY ALCOHOL FROM A CORRESPONDING KETONE WITHOUT REDUCING DEUTERIUM INCORPORATION
    Publication number: 20150376665
    Abstract: The present invention provides a process for the preparation of enantiomerically enriched, deuterated secondary alcohols of Formula 1-A by employing ketoreductases or carbonyl reductases without reducing deuterium incorporation.
    Type: Application
    Filed: July 1, 2015
    Publication date: December 31, 2015
    Inventors: Ramanaiah C. Kanamarlapudi, Steven A. Weissman, Emerich Eisenreich, Xuejun Liu
  • Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
    Patent number: 9085788
    Abstract: The present invention provides a convenient and efficient process for the preparation of enantiomerically enriched, deuterated secondary alcohols without reducing deuterium incorporation.
    Type: Grant
    Filed: September 1, 2011
    Date of Patent: July 21, 2015
    Assignee: Concert Pharmaceuticals, Inc.
    Inventors: Ramanaiah C. Kanamarlapudi, Steven A. Weissman, Emerich Eisenreich, Xuejun Liu
  • Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
    Patent number: 9074233
    Abstract: The present invention provides a process for the preparation of enantiomerically enriched, deuterated secondary alcohols of Formula 1-A by employing ketoreductases or carbonyl reductases without reducing deuterium incorporation.
    Type: Grant
    Filed: September 1, 2011
    Date of Patent: July 7, 2015
    Assignee: Concert Pharmaceuticals, Inc.
    Inventors: Ramanaiah C. Kanamarlapudi, Steven A. Weissman, Emerich Eisenreich, Xuejun Liu
  • Process for preparing N-substituted hydroxypyrimidinone carboxamides
    Patent number: 8686141
    Abstract: Processes for preparing certain N-arylalkyl-1-(alkyl or aralkyl)-2-acylaminoalkyl-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamides are disclosed. In one embodiment, the process comprises acylating the free amine in the corresponding N-arylalkyl-1-(alkyl or aralkyl)-2-aminoalkyl-5-ester protected hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide and then deprotecting the 5-hydroxy by base hydrolysis. The hydroxypyrimidinone carboxamide products of the process are HTV integrase inhibitors which are useful for treating HTV infection, treating AIDS, or delaying the onset or progression of AIDS. Certain esterified N-arylalkyl hydroxypyrimidinone carboxamides that can be employed as process intermediates are also disclosed.
    Type: Grant
    Filed: December 22, 2008
    Date of Patent: April 1, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Guy R. Humphrey, Ross A. Miller, Peter E. Maligres, Steven Weissman
  • PROCESS FOR PREPARING AN ENANTIOMERICALLY ENRICHED, DEUTERATED SECONDARY ALCOHOL FROM A CORRESPONDING KETONE WITHOUT REDUCING DEUTERIUM INCORPORATION
    Publication number: 20140017739
    Abstract: The present invention provides a convenient and efficient process for the preparation of enantiomerically enriched, deuterated secondary alcohols without reducing deuterium incorporation.
    Type: Application
    Filed: September 1, 2011
    Publication date: January 16, 2014
    Applicant: CONCERT PHARMACEUTICALS, INC.
    Inventors: Ramanaiah C. Kanamarlapudi, Steven A. Weissman, Emerich Eisenreich, Xuejun Liu
  • PROCESS FOR PREPARING AN ENANTIOMERICALLY ENRICHED, DEUTERATED SECONDARY ALCOHOL FROM A CORRESPONDING KETONE WITHOUT REDUCING DEUTERIUM INCORPORATION
    Publication number: 20130280768
    Abstract: The present invention provides a process for the preparation of enantiomerically enriched, deuterated secondary alcohols of Formula 1-A by employing ketoreductases or carbonyl reductases without reducing deuterium incorporation.
    Type: Application
    Filed: September 1, 2011
    Publication date: October 24, 2013
    Applicant: CONCERT PHARMACEUTICALS, INC.
    Inventors: Ramanaiah C. Kanamarlapudi, Steven A. Weissman, Emerich Eisenreich, Xuejun Liu
  • PROCESS FOR PREPARING N-SUBSTITUTED HYDROXYPYRIMIDINONE CARBOXAMIDES
    Publication number: 20100280244
    Abstract: Processes for preparing certain N-arylalkyl-1-(alkyl or aralkyl)-2-acylaminoalkyl-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamides are disclosed. In one embodiment, the process comprises acylating the free amine in the corresponding N-arylalkyl-1-(alkyl or aralkyl)-2-aminoalkyl-5-ester protected hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide and then deprotecting the 5-hydroxy by base hydrolysis. The hydroxypyrimidinone carboxamide products of the process are HTV integrase inhibitors which are useful for treating HTV infection, treating AIDS, or delaying the onset or progression of AIDS. Certain esterified N-arylalkyl hydroxypyrimidinone carboxamides that can be employed as process intermediates are also disclosed.
    Type: Application
    Filed: December 22, 2008
    Publication date: November 4, 2010
    Inventors: Guy R. Humphrey, Ross A. Miller, Peter E. Maligres, Steven Weissman
  • Synthesis and crystalline forms of NPY5 antagonist
    Patent number: 7700611
    Abstract: The present invention relates to a process for producing crystalline trans-N-[1-(2-fluorophenyl)-S-pyrazoly]-3-ox-ospiro[6-azaisobenzofuran-1(3H),1?-cyclohexane]-4?-carboxamide and novel salts, hydrates and polymorphs thereof.
    Type: Grant
    Filed: July 24, 2006
    Date of Patent: April 20, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Russell R. Ferlita, Yuji Haga, Makoto Ishikawa, Keisuke Kamei, Shinji Kato, Hisaki Kojima, Aaron Moment, Nobuaki Nonoyama, Nobuya Satake, Kazuki Shigemori, Toshihiro Wada, Yaling Wang, Steven A. Weissman, Robert M. Wenslow
  • Cyanation of aromatic halides
    Patent number: 7595417
    Abstract: A practical, ligand-free cyanation of aryl bromides employs Pd catalyst in combination with a non-toxic cyanide source, Mn[Fe(CN)6] (M=K or Na; n is 3 or 4), or a hydrate thereof, and a base. The reactions are performed in a polar aprotic solvents and provide the corresponding aryl nitrile in 83-96% yield, typically in less than 5 h.
    Type: Grant
    Filed: November 14, 2005
    Date of Patent: September 29, 2009
    Assignee: Merck & Co., Inc.
    Inventor: Steven A. Weissman
  • Synthesis and Crystalline Forms of Npy5 Antagonist
    Publication number: 20090124648
    Abstract: The present invention relates to a process for producing crystalline trans-N-[1-(2-fluorophenyl)-S-pyrazoly]-3-ox-ospiro[6-azaisobenzofuran-1(3H),1?-cyclohexane]-4?-carboxamide and novel salts, hydrates and polymorphs thereof.
    Type: Application
    Filed: July 24, 2006
    Publication date: May 14, 2009
    Inventors: Russell R. Ferlita, Yuji Haga, Makoto Ishikawa, Keisuke Kamei, Shinji Kato, Hisaki Kojima, Aaron Moment, Nobuaki Nonoyama, Nobuya Satake, Kazuki Shigemori, Toshihiro Wada, Yaling Wang, Steven A. Weissman, Robert M. Wenslow
  • Process for making spirolactone compounds
    Patent number: 7482449
    Abstract: This invention relates to a process for making spirolactone compounds analogous to formula I.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: January 27, 2009
    Assignees: Merck & Co., Inc., Banyu Pharmaceutical Co., Ltd.
    Inventors: Ralph P. Volante, David M. Tschaen, Steven A. Weissman, Matthew Heileman, Toshiaki Mase, Takehiko Iida, Kenji Maeda, Toshihiro Wada, Hiroki Sato, Kenichi Asakawa
  • Process for making spirolactone compounds
    Publication number: 20080171888
    Abstract: This invention relates to a process for making spirolactone compounds analogous to formula I.
    Type: Application
    Filed: March 19, 2008
    Publication date: July 17, 2008
    Inventors: Ralph P. Volante, David M. Tschaen, Steven A. Weissman, Matthew Heileman, Toshiaki Mase, Takehiko Iida, Kenji Maeda, Toshihiro Wada, Hiroki Sato, Kenichi Asakawa
  • Process for making spirolactone compounds
    Patent number: 7368569
    Abstract: This invention relates to a process for making spirolactone compounds analogous to formula I
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: May 6, 2008
    Assignees: Merck & Co., Inc., Banyu Pharmaceutical Co., Ltd.
    Inventors: Ralph P. Volante, David M. Tschaen, Steven A. Weissman, Matthew Heileman, Toshiaki Mase, Takehiko Iida, Kenji Maeda, Toshihiro Wada, Hiroki Sato, Kenichi Asakawa
  • Process for making spirolactone compounds
    Publication number: 20060241299
    Abstract: This invention relates to a process for making spirolactone compounds of general formula I, having an improved IA/IB ratio, according to the following shceme.
    Type: Application
    Filed: May 14, 2004
    Publication date: October 26, 2006
    Inventors: Ralph Volante, Steven Weissman, Takehiko Iida, Yuhei Yamamoto, Hiroki Sato, Kenji Maeda, Naotaka Sawada, Toshiaki Mase