Abstract: The natural product neurolenin D is isolated from Neurolaena lobata using continuous extraction, stirring over charcoal, flash column chromatography, and recrystallization. The secondary alcohol in this molecule is converted into a methane sulfonyl ester (mesylate) to generate a new molecule, neurolenin D mesylate. This previously unknown molecule has been tested for biological activity in assays for human toxicity, mutagenicity, and nematocidal potency. It is not toxic or mutagenic and demonstrates the ability to kill nematodes responsible for the neglected tropical disease lymphatic filariasis and is likely to have the same ability to kill other nematodes responsible for a wide range of diseases in humans, animals and plants. Additional esters of neurolenin D are claimed and procedures are outlined for their synthesis.

Abstract: Platforms, including devices, systems, kits, and methods, are provided for the differential detection of Dirofilaria immitis and Dirofilaria. repens in an animal host using parasite-specific DNA target capture techniques as well as polymerase chain reaction detection of those targets.

Abstract: Methods, processes, compositions and systems for preventing leaching effects from water pipes (such as lead, steel and copper) having an inner diameter of at least approximately 12 mm. 2-part thermoset resin coating is applied to the inner surfaces of the pipes where the curing agent can be a phenol free and plasticizer free adduct type. The coating can reduce heavy metals, such as lead, from leaching from installed pipes to less than approximately 10 ?g/L (10 ppb). When cured, specific leachates, Bisphenol A and Epichlorohydrin from the coatings will be (less than) <1 ?g/L (1 ppb) with overall TOC levels measured at (less than) <2.5 mg/L (2.5 ppm). Pipes can be returned to service within approximately 24 hours, and preferably within approximately 4 hours. The methods, processes, compositions and systems can work with non-metallic pipes having metal valves and/or metal fittings.

Abstract: Methods, processes, compositions and systems for preventing leaching effects from water pipes (such as lead, steel and copper) having an inner diameter of at least approximately 12 mm. 2-part thermoset resin coating is applied to the inner surfaces of the pipes where the curing agent can be a phenol free and plasticizer free adduct type. The coating can reduce heavy metals, such as lead, from leaching from installed pipes to less than approximately 10 ?g/L (10 ppb). When cured, specific leachates, Bisphenol A and Epichlorohydrin from the coatings will be (less than)<1 ?g/L (1 ppb) with overall TOC levels measured at (less than)<2.5 mg/L (2.5 ppm). Pipes can be returned to service within approximately 24 hours, and preferably within approximately 4 hours. The methods, processes, compositions and systems can work with non-metallic pipes having metal valves and/or metal fittings.

Abstract: Methods, processes, compositions and systems for preventing leaching effects from water pipes (such as lead, steel and copper) having an inner diameter of at least approximately 12 mm. 2-part thermoset resin coating is applied to the inner surfaces of the pipes where the curing agent can be a phenol free and plasticizer free adduct type. The coating can reduce heavy metals, such as lead, from leaching from installed pipes to less than approximately 10 ?g/L (10 ppb). When cured, specific leachates, Bisphenol A and Epichlorohydrin from the coatings will be (less than) <1 ?g/L (1 ppb) with overall TOC levels measured at (less than) <2.5 mg/L (2.5 ppm). Pipes can be returned to service within approximately 24 hours, and preferably within approximately 4 hours.

Abstract: Methods and systems for providing cleaning and providing barrier coatings to interior wall surfaces of small diameter nonmetal and composite piping systems in buildings, swimming pools, underground pipes, in-slab piping systems, piping under driveways and various liquid transmission lines. An entire piping system can be cleaned in one single pass by dry particulates forced by air throughout the building piping system by an external generator, and the entire piping system can be coated in one single pass by a machine connected exterior to the piping system. Small pipes can be protected by the effects of water corrosion, erosion and electrolysis, extending the life of piping systems such as plastics, PVC (polyvinyl chloride), composite materials, polybutylene.

Abstract: Methods and systems for cleaning, coating and sealing leaks in existing nonmetal pipes, in a single operation. A nonmetal piping system can be cleaned in one pass by dry particulates forced and pulled by air throughout the piping system by a generator and a vacuum. Nonmetal pipes with nonmetal fittings or nonmetal pipes with metal fittings or nonmetal pipes with a combination of metal and nonmetal fittings can be protected from wear by water erosion and rupturing, extending the life of pipes made of a nonmetal material selected from at least one of plastics, PVC (polyvinyl chloride), composite materials, or polybutylene. Coatings can be applied to nonmetal pipes having diameters up to approximately 6?. Leak sealants of at least approximately 4 mils thick can cover insides of nonmetal pipes, and can include novel mixtures of fillers and epoxy materials, and viscosity levels. A positive pressure can be maintained within the nonmetal pipes during applications.

Abstract: Methods and systems for cleaning, coating and sealing leaks in existing nonmetal pipes, in a single operation. A nonmetal piping system can be cleaned in one pass by dry particulates forced and pulled by air throughout the piping system by a generator and a vacuum. Nonmetal pipes with nonmetal fittings or nonmetal pipes with metal fittings or nonmetal pipes with a combination of metal and nonmetal fittings can be protected from wear by water erosion and rupturing, extending the life of pipes made of a nonmetal material selected from at least one of plastics, PVC (polyvinyl chloride), composite materials, or polybutylene. Coatings can be applied to nonmetal pipes having diameters up to approximately 6?. Leak sealants of at least approximately 4 mils thick can cover insides of nonmetal pipes, and can include novel mixtures of fillers and epoxy materials, and viscosity levels. A positive pressure can be maintained within the nonmetal pipes during applications.

Abstract: Methods and systems for providing cleaning and providing barrier coatings to interior wall surfaces of small diameter nonmetal and composite piping systems in buildings, swimming pools, underground pipes, in-slab piping systems, piping under driveways and various liquid transmission lines. An entire piping system can be cleaned in one single pass by dry particulates forced by air throughout the building piping system by an external generator, and the entire piping system can be coated in one single pass by a machine connected exterior to the piping system. Small pipes can be protected by the effects of water corrosion, erosion and electrolysis, extending the life of piping systems such as plastics, PVC (polyvinyl chloride), composite materials, polybutylene.

Abstract: Methods and systems for cleaning, coating and sealing leaks in existing pipes made of nonmetal materials selected from a nonmetal material selected from at least one of plastics, PVC (polyvinyl chloride), composite materials, or polybutylene, in a single operation. A piping system can be cleaned in one pass by dry particulates forced and pulled by air throughout the piping system by a generator and a vacuum. Pipes with nonmetal fittings or with metal fittings or pipes with a combination of metal and nonmetal fittings can be protected from wear by water erosion and rupturing, extending the life of pipes made of nonmetal materials selected from at least one of plastics, PVC (polyvinyl chloride), composite materials, or polybutylene. Coatings can be applied to pipes having diameters up to approximately 6?. Leak sealants of at least approximately 4 mils thick can cover insides of pipes, and can include novel mixtures of fillers and epoxy materials, and viscosity levels.

Abstract: Methods and systems for providing cleaning and providing barrier coatings to interior wall surfaces of small diameter nonmetal and composite piping systems in buildings, swimming pools, underground pipes, in-slab piping systems, piping under driveways and various liquid transmission lines. An entire piping system can be cleaned in one single pass by dry particulates forced by air throughout the building piping system by an external generator, and the entire piping system can be coated in one single pass by a machine connected exterior to the piping system. Small pipes can be protected by the effects of water corrosion, erosion and electrolysis, extending the life of piping systems such as plastics, PVC (polyvinyl chloride), composite materials, polybutylene.

Abstract: Methods, processes, compositions and systems for preventing leaching effects from water pipes (such as lead, steel and copper) having an inner diameter of at least approximately 12 mm. 2-part thermoset resin coating is applied to the inner surfaces of the pipes where the curing agent can be a phenol free and plasticizer free adduct type. The coating can reduce heavy metals, such as lead, from leaching from installed pipes to less than approximately 10 ?g/L (10 ppb). When cured, specific leachates, Bisphenol A and Epichlorohydrin from the coatings will be (less than) <1 ?g/L (1 ppb) with overall TOC levels measured at (less than) <2.5 mg/L (2.5 ppm). Pipes can be returned to service within approximately 24 hours, and preferably within approximately 4 hours.

Abstract: Methods and systems for providing cleaning and providing barrier coatings to interior wall surfaces of small diameter nonmetal and composite piping systems in buildings, swimming pools, underground pipes, in-slab piping systems, piping under driveways and various liquid transmission lines. An entire piping system can be cleaned in one single pass by dry particulates forced by air throughout the building piping system by an external generator, and the entire piping system can be coated in one single pass by a machine connected exterior to the piping system. Small pipes can be protected by the effects of water corrosion, erosion and electrolysis, extending the life of piping systems such as plastics, PVC (polyvinyl chloride), composite materials, polybutylene.

Abstract: Methods and systems for cleaning, coating and sealing leaks in existing nonmetal pipes, in a single operation. A nonmetal piping system can be cleaned in one pass by dry particulates forced and pulled by air throughout the piping system by a generator and a vacuum. Nonmetal pipes with nonmetal fittings or nonmetal pipes with metal fittings or nonmetal pipes with a combination of metal and nonmetal fittings can be protected from wear by water erosion and rupturing, extending the life of pipes made of a nonmetal material selected from at least one of plastics, PVC (polyvinyl chloride), composite materials, or polybutylene. Coatings can be applied to nonmetal pipes having diameters up to approximately 6?. Leak sealants of at least approximately 4 mils thick can cover insides of nonmetal pipes, and can include novel mixtures of fillers and epoxy materials, and viscosity levels. A positive pressure can be maintained within the nonmetal pipes during applications.

Abstract: Methods, processes, compositions and systems for preventing leaching effects from water pipes (such as lead, steel and copper) having an inner diameter of at least approximately 12 mm. 2-part thermoset resin coating is applied to the inner surfaces of the pipes where the curing agent can be a phenol free and plasticizer free adduct type. The coating can reduce heavy metals, such as lead, from leaching from installed pipes to less than approximately 10 ?g/L (10 ppb). When cured, specific leachates, Bisphenol A and Epichlorohydrin from the coatings will be (less than)<1 ?g/L (1 ppb) with overall TOC levels measured at (less than)<2.5 mg/L (2.5 ppm). Pipes can be returned to service within approximately 24 hours, and preferably within approximately 4 hours.

Abstract: Methods, processes, compositions and systems for preventing leaching effects from water pipes (such as lead, steel and copper) having an inner diameter of at least approximately 12 mm. 2-part thermoset resin coating is applied to the inner surfaces of the pipes where the curing agent can be a phenol free and plasticizer free adduct type. The coating can reduce heavy metals, such as lead, from leaching from installed pipes to less than approximately 10 ?g/L (10 ppb). When cured, specific leachates, Bisphenol A and Epichlorohydrin from the coatings will be (less than)<1 ?g/L (1 ppb) with overall TOC levels measured at (less than)<2.5 mg/L (2.5 ppm). Pipes can be returned to service within approximately 24 hours, and preferably within approximately 4 hours.

Abstract: Methods, processes, compositions and systems for preventing leaching effects from drinking water service pipes (such as lead, steel and copper) having an inner diameter of at least approximately 12 mm. 2-part thermoset resin coating is applied to the inner surfaces of the pipes where the curing agent can be a phenol free and plasticizer free adduct type. The coating can reduce heavy metals, such as lead, from leaching from installed pipes to less than approximately 10 ?g/L (10 ppb). When cured, specific leachates, Bisphenol A and Epichlorohydrin from the coatings will be (less than) <1 ?g/L (1 ppb) with overall TOC levels measured at (less than) <2.5 mg/L (2.5 ppm). Pipes can be returned to service from at least approximately 1 to approximately 2 hours.

Abstract: Methods and process steps for mapping, cleaning and providing barrier coatings to interior walls of piping systems. An entire piping system can be cleaned in one single pass by dry particulates forced by air and the piping system coated in one single pass. Pipes can be protected from water corrosion, erosion and electrolysis. Pipes having diameters of approximately ?? up to approximately 6? are treatable. Piping systems such as potable water lines, natural gas lines, HVAC, drains, and fire sprinkler systems in homes, apartments, high-rise hotel/resorts, office towers, high-rise apartment and condominiums and schools, can be treated. The coating forms an approximately 4 mils or greater covering inside the pipes. Buildings can return to service within approximately 24 to approximately 96 hours.

Abstract: A sensor pad that is adapted to be positioned on a patient's bed or chair as part of a monitoring system that provides a signal to a caregiver when the patient rises from the bed or chair also indicates when the pad is near failure. The sensor pad includes specialized contact plate patterning that creates zones on the sensor pad.

Abstract: Methods, processes, compositions and systems for preventing leaching effects from drinking water service pipes (such as lead, steel and copper) having an inner diameter of at least approximately 12 mm. 2-part thermoset resin coating is applied to the inner surfaces of the pipes where the curing agent can be a phenol free and plasticizer free adduct type. The coating can reduce heavy metals, such as lead, from leaching from installed pipes to less than approximately 10 ?g/L (10 ppb). When cured, specific leachates, Bisphenol A and Epichlorohydrin from the coatings will be (less than) <1 ?g/L (1 ppb) with overall TOC levels measured at (less than) <2.5 mg/L (2.5 ppm). Pipes can be returned to service from at least approximately 1 to approximately 2 hours.