Patents by Inventor Steven Alexander Keatch
Steven Alexander Keatch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240017254Abstract: Described herein is a system and method for determining the presence and/or amount of a target in a sample. In some embodiments, a microfluidic device, such as a strip having a microfluidic network thereon, is inserted into an instrument to perform an assay therein. The strip may be configured to receive the sample from a porous member via capillary action, with minimal or no compression of the porous member. The instrument may include a gas bladder actuation assembly, actuated by an eccentric cam, to compress and decompress a gas bladder on the microfluidic device, thereby enabling fluid movement thereon. The instrument may further comprise a magnet disposed in a fixed location, so as to capture any complexes formed between the target and magnetic particles disposed within the microfluidic device. The magnet may be aligned with an optical detection assembly configured to detect the target captured with the magnetic particles.Type: ApplicationFiled: November 10, 2021Publication date: January 18, 2024Applicant: LumiraDx UK Ltd.Inventors: Phill Lowe, Christopher John Slevin, Brian McGuigan, Steven Alexander Keatch, David Lang, Aman Murtaza Khan
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Publication number: 20230144460Abstract: A diagnostic system for determining the presence of a target in a sample liquid that includes a diagnostic reader and a microfluidic strip having a microfluidic channel network therein. An actuator within the reader modifies the pressure of a gas in gaseous communication with a liquid-gas interface of a sample liquid within the microfluidic channel network to move and/or mix the sample liquid. The pressure modifications may be continuous and/or oscillatory.Type: ApplicationFiled: July 8, 2022Publication date: May 11, 2023Inventors: Aman Murtaza Khan, Badr Aman Khan, Brian McGuigan, David William Taylor, David Kinniburgh Lang, John Iain William Deane, Lois Bello Fernandez De Sanmamed, Michael Flett, Phill Lowe, Steven Alexander Keatch, Usman Ali Khan, Dave Scott, Thomas J. Quinlan, Nigel Malcolm Lindner, Marcus Twomey, Graeme John McInnes
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Publication number: 20220193672Abstract: The present invention relates to a microfluidic based assay system, comprising a disposable assay cartridge and associated reading device, as well as the individual components themselves. The present invention also relates to methods of conducting assays, using the cartridge and device of the invention, as well as kits for conducting assays.Type: ApplicationFiled: February 10, 2022Publication date: June 23, 2022Inventors: Phillip Lowe, Steven Alexander Keatch, Brian McGuigan
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Patent number: 11278886Abstract: The present invention relates to a microfluidic based assay system, comprising a disposable assay cartridge and associated reading device, as well as the individual components themselves. The present invention also relates to methods of conducting assays, using the cartridge and device of the invention, as well as kits for conducting assays.Type: GrantFiled: May 20, 2019Date of Patent: March 22, 2022Assignee: LumiraDx UK Ltd.Inventors: Phillip Lowe, Steven Alexander Keatch, Brian McGuigan
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Publication number: 20210402388Abstract: The present invention relates to a microfluidic assay system and associated reading device, as well as the individual components themselves. The present invention also relates to methods of conducting assays, using a disposable system and associated reading device, as well as kits for conducting assays.Type: ApplicationFiled: April 12, 2021Publication date: December 30, 2021Inventors: Steven Alexander Keatch, Phill Lowe, Brian McGuigan, Andrew Peter Phelan, Aman Khan
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Publication number: 20210263028Abstract: The present invention relates to methods for detecting an analyte present in a fluid sample using a microfluidic device comprising a detection zone characterized by an optically transmissible portion and reagent(s) associated with a porous matrix, wherein the analyte is detected with an optical detector. The present invention also provides a microfluidic channel and a microfluidic cartridge for use in such a method.Type: ApplicationFiled: September 13, 2019Publication date: August 26, 2021Inventors: Phill Lowe, Steven Alexander Keatch, Brian McGuigan, Lois Bello, Chris Slevin, David Lang, John Dilieen
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Patent number: 11000847Abstract: The present invention relates to a microfluidic assay system and associated reading device, as well as the individual components themselves. The present invention also relates to methods of conducting assays, using a disposable system and associated reading device, as well as kits for conducting assays.Type: GrantFiled: June 30, 2017Date of Patent: May 11, 2021Assignee: LumiraDx UK Ltd.Inventors: Steven Alexander Keatch, Phil Lowe, Brian McGuigan, Andrew Peter Phelan, Aman Khan
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Publication number: 20200078784Abstract: The present invention relates to a microfluidic based assay system, comprising a disposable assay cartridge and associated reading device, as well as the individual components themselves. The present invention also relates to methods of conducting assays, using the cartridge and device of the invention, as well as kits for conducting assays.Type: ApplicationFiled: May 20, 2019Publication date: March 12, 2020Inventors: Phil Lowe, Steven Alexander Keatch, Brian McGuigan
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Patent number: 10509032Abstract: An assay method and device can perform at least one (e.g., at least two) assays on a single aliquot of a sample liquid. The device can mix a sample liquid with assay reagents including magnetically susceptible particles. The device is configured to create a sample liquid-air interface with the sample liquid. The magnetically susceptible particles can be located (via an applied magnetic field) at the liquid-air interface when a second liquid contacts the interface to form a liquid-liquid interface. The magnetic particles travel across the liquid-liquid interface to the second liquid. The magnetically susceptible particles are configured to trans-port an analyte across the interface into the second liquid. An assay for the analyte is performed in the second liquid. An assay for another analyte can also be performed in the sample liquid.Type: GrantFiled: February 27, 2017Date of Patent: December 17, 2019Assignee: ALERE SWITZERLAND GMBHInventors: Phillip Lowe, Steven Alexander Keatch, Steven Howell, Claus Marquordt, Ruth Polwart, Alan Kenneth Thomson
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Patent number: 10376881Abstract: The present invention relates to a microfluidic based assay system, comprising a disposable assay cartridge and associated reading device, as well as the individual components themselves. The present invention also relates to methods of conducting assays, using the cartridge and device of the invention, as well as kits for conducting assays.Type: GrantFiled: September 7, 2011Date of Patent: August 13, 2019Assignee: LumiraDx UK Ltd.Inventors: Phillip Lowe, Steven Alexander Keatch, Brian McGuigan
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Publication number: 20190160460Abstract: The present invention relates to a microfluidic assay system and associated reading device, as well as the individual components themselves. The present invention also relates to methods of conducting assays, using a disposable system and associated reading device, as well as kits for conducting assays.Type: ApplicationFiled: June 30, 2017Publication date: May 30, 2019Applicant: LumiraDx UK Ltd.Inventors: Steven Alexander Keatch, Phil Lowe, Brian McGuigan, Andrew Peter Phelan, Aman Khan
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Patent number: 10261077Abstract: A subtractive corrective assay device and methodology, whereby ail required binding and label detection reagents are initially located within the detection zone. Application of a magnetic field is used to selectively remove bound label from the detection zone by means of paramagnetic particles. The relationship between measured label concentration before and after the application of a magnetic field within the detection zone is used to accurately measure analyte concentration within the sample.Type: GrantFiled: May 16, 2016Date of Patent: April 16, 2019Assignee: LUMIRADX UK LTDInventors: Phillip Lowe, Steven Alexander Keatch, Brian McGuigan
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Publication number: 20180059105Abstract: An assay method and device can perform at least one (e.g., at least two) assays on a single aliquot of a sample liquid. The device can mix a sample liquid with assay reagents including magnetically susceptible particles. The device is configured to create a sample liquid-air interface with the sample liquid. The magnetically susceptible particles can be located (via an applied magnetic field) at the liquid-air interface when a second liquid contacts the interface to form a liquid-liquid interface. The magnetic particles travel across the liquid-liquid interface to the second liquid. The magnetically susceptible particles are configured to trans-port an analyte across the interface into the second liquid. An assay for the analyte is performed in the second liquid. An assay for another analyte can also be performed in the sample liquid.Type: ApplicationFiled: February 27, 2017Publication date: March 1, 2018Applicant: INVERNESS MEDICAL SWITZERLAND GMBHInventors: Phillip Lowe, Steven Alexander Keatch, Steven Howell, Claus Marquordt, Ruth Polwart, Alan Kenneth Thomson
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Patent number: 9618506Abstract: An assay method and device can perform at least one (e.g., at least two) assays on a single aliquot of a sample liquid. The device can mix a sample liquid with assay reagents including magnetically susceptible particles. The device is configured to create a sample liquid-air interface with the sample liquid. The magnetically susceptible particles can be located (via an applied magnetic field) at the liquid-air interface when a second liquid contacts the interface to form a liquid-liquid interface. The magnetic particles travel across the liquid-liquid interface to the second liquid. The magnetically susceptible particles are configured to transport an analyte across the interface into the second liquid. An assay for the analyte is performed in the second liquid. An assay for another analyte can also be performed in the sample liquid.Type: GrantFiled: March 29, 2007Date of Patent: April 11, 2017Assignee: INVERNESS MEDICAL SWITZERLAND GMBHInventors: Phillip Lowe, Steven Alexander Keatch, Steven Howell, Claus Marquordt, Ruth Polwart, Alan Kenneth Thomson
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Publication number: 20160320374Abstract: A subtractive corrective assay device and methodology, whereby ail required binding and label detection reagents are initially located within the detection zone. Application of a magnetic field is used to selectively remove bound label from the detection zone by means of paramagnetic particles. The relationship between measured label concentration before and after the application of a magnetic field within the detection zone is used to accurately measure analyte concentration within the sample.Type: ApplicationFiled: May 16, 2016Publication date: November 3, 2016Inventors: Phillip LOWE, Steven Alexander KEATCH, Brian McGUIGAN
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Patent number: 9341620Abstract: A subtractive corrective assay device and methodology, whereby ail required binding and label detection reagents are initially located within the detection zone. Application of a magnetic field is used to selectively remove bound label from the detection zone by means of paramagnetic particles. The relationship between measured label concentration before and after the application of a magnetic field within the detection zone is used to accurately measure analyte concentration within the sample.Type: GrantFiled: February 7, 2012Date of Patent: May 17, 2016Assignee: Multi-Sense Technologies LimitedInventors: Phillip Lowe, Steven Alexander Keatch, Brian McGuigan
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Patent number: 9063132Abstract: An assay method and device can perform at least one (e.g., at least two) assays on a single aliquot of a sample liquid. The device can mix a sample liquid with assay reagents including magnetically susceptible particles. The device is configured to create a sample liquid-air interface with the sample liquid. The magnetically susceptible particles can be located (via an applied magnetic field) at the liquid-air interface when a second liquid contacts the interface to form a liquid-liquid interface. The magnetic particles travel across the liquid:liquid interface to the second liquid. The magnetically susceptible particles are configured to transport an analyte across the interface into the second liquid. An assay for the analyte is performed in the second liquid. An assay for another analyte can also be performed in the sample liquid.Type: GrantFiled: April 2, 2010Date of Patent: June 23, 2015Assignee: INVERNESS MEDICAL SWITZERLAND GMBHInventors: John William Dilleen, Phillip Lowe, Ruth Polwart, Jennifer Hay, Claus Marquordt, Steven Alexander Keatch, Steven Howell, Alan Thomson
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Publication number: 20140017709Abstract: A subtractive corrective assay device and methodology, whereby ail required binding and label detection reagents are initially located within the detection zone. Application of a magnetic field is used to selectively remove bound label from the detection zone by means of paramagnetic particles. The relationship between measured label concentration before and after the application of a magnetic field within the detection zone is used to accurately measure analyte concentration within the sample.Type: ApplicationFiled: February 7, 2012Publication date: January 16, 2014Applicant: MULTI-SENSE TECHNOLOGIES LIMITEDInventors: Phillip Lowe, Steven Alexander Keatch, Brian Mcguigan
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Publication number: 20130309778Abstract: The present invention relates to a microfluidic based assay system, comprising a disposable assay cartridge and associated reading device, as well as the individual components themselves. The present invention also relates to methods of conducting assays, using the cartridge and device of the invention, as well as kits for conducting assays.Type: ApplicationFiled: September 7, 2011Publication date: November 21, 2013Applicant: MULTI-SENSE TECHNOLOGIES LIMITEDInventors: Phillip Lowe, Steven Alexander Keatch, Brian McGuigan
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Publication number: 20110053289Abstract: An assay method and device can perform at least one (e.g., at least two) assays on a single aliquot of a sample liquid. The device can mix a sample liquid with assay reagents including magnetically susceptible particles. The device is configured to create a sample liquid-air interface with the sample liquid. The magnetically susceptible particles can be located (via an applied magnetic field) at the liquid-air interface when a second liquid contacts the interface to form a liquid-liquid interface. The magnetic particles travel across the liquid-liquid interface to the second liquid. The magnetically susceptible particles are configured to trans-port an analyte across the interface into the second liquid. An assay for the analyte is performed in the second liquid. An assay for another analyte can also be performed in the sample liquid.Type: ApplicationFiled: March 29, 2007Publication date: March 3, 2011Applicant: INVERNESS MEDICAL SWITZERLAND GMBHInventors: Phillip Lowe, Steven Alexander Keatch, Steven Howell, Claus Marquordt, Ruth Polwart, Alan Kenneth Thomson