Abstract: A brine waste management method comprising the utilization of brine waste as a growth medium for cultures of genetically modified halophiles acting as bio-refineries creating chemicals of value. Brine waste enters the method (101) to undergo compositional analysis (102), Pretreatment (104), and Inoculation (106). The compositional analysis (102) and the selection (103) of the chemicals of value influences the selection (103) of the halophile species to undergo modification (105), as well as the pretreatment (104) needed to encourage growth-production (107). Growth-production (107) is monitored and assisted until the extraction (108) of the chemicals of value and additional post-extraction (109) handling of excess brine waste exiting the method.