Abstract: An electrophoresis system for removing or reducing concentration of a metabolic component from blood or plasma of a subject is provided. A method for removing or reducing concentration or amount of a metabolic component in blood or plasma of a subject is also provided. The system and method include use of a set of ion permeable barriers and the application of an electrical potential across these barriers to selectively remove metabolic components from blood or plasma.

Abstract: An electrophoresis system for removing or reducing concentration of a metabolic component from blood or plasma of a subject, the system comprising: (a) a first ion-permeable barrier having a defined pore size and pore size distribution disposed in an electric field area; (b) a second ion-permeable barrier having a defined pore size and pore size distribution disposed between a cathode zone and the first barrier so as to define a treatment chamber therebetween; (c) means adapted for cooling blood or plasma from the subject; (d) means adapted to provide dialysate to the cathode zone and an anode zone; and (e) means adapted to provide blood or plasma from the subject to the treatment chamber; wherein, upon application of the electric potential, a metabolic component from the blood or plasma moves through at least one barrier into at least one of the cathode or anode zones.

Abstract: An electrophoresis apparatus comprising: a first electrode in a first electrode zone; a second electrode in a second electrode zone, the first electrode disposed relative to the second electrode so as to be adapted to generate an electric field in an electric field area therebetween upon application of an electric potential between the first and second electrodes; a first membrane disposed in the electric field area; a second membrane disposed between the first electrode zone and the first membrane so as to define a first interstitial volume therebetween; wherein at least one membrane being a barrier capable of controlling substantial bulk movement of liquid under the influence of an electric field; means adapted to provide fluids to the electrode zone and the interstitial volume, wherein one of the fluids contains a sample constituent, and wherein upon application of the electric potential, liquid is caused to move from the sample constituent through at least one membrane to an adjacent electrode zone and at