Patents by Inventor Steven Anthony Kliewer

Steven Anthony Kliewer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for hepatoprotection and treatment of cholestasis
    Patent number: 6987121
    Abstract: Methods for the treatment of cholestatic liver disease and reduction and prevention of hepatic injury resulting from cholestasis via administration of a FXR ligand are provided.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: January 17, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: Steven Anthony Kliewer, Timothy Mark Willson, Traci Mansfield
  • Nonhuman pregnane x receptor sequences for use in comparative pharmacology
    Publication number: 20040171811
    Abstract: Polynucleotides and polypeptides of canine, primate, porcine and fish pregnane X receptor (PXR), as well as expression vectors and host cells for expression of these PXR receptors, are provided. Also provided are methods for screening for modulators of these PXR receptors and using these receptors for comparative pharmacology and in selection of appropriate preclinical animal models predictive of human PXR activity.
    Type: Application
    Filed: November 21, 2003
    Publication date: September 2, 2004
    Inventors: Steven Anthony Kliewer, Jodi Marie Maglich, John Tomlin Moore, Linda Becker Moore, Timothy Mark Willson
  • Identification of new therapeutic targets for modulating bile acid synthesis
    Publication number: 20040038862
    Abstract: Abstract: Methods for identifying compounds that modulate bile acid synthesis by assessing their ability to act as ligands for short heterodimerizing partner-1 or liver receptor homologue-1 are provided. Also provided are compositions containing these ligands as well as methods for administering these compositions to modulate bile acid synthesis and cholesterol and lipid homeostasis.
    Type: Application
    Filed: January 28, 2003
    Publication date: February 26, 2004
    Inventors: Bryan James Goodwin, Stacey Ann Jones, Steven Anthony Kliewer, Patrick Reed Maloney
  • COMPOSITIONS AND METHODS FOR HEPATOPROTECTION AND TREATMENT OF CHOLESTASIS
    Publication number: 20030203939
    Abstract: Methods for the treatment of cholestatic liver disease and reduction and prevention of hepatic injury resulting from cholestasis via administration of a FXR ligand are provided.
    Type: Application
    Filed: April 25, 2002
    Publication date: October 30, 2003
    Inventors: Steven Anthony Kliewer, Timothy Mark Willson
  • Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma
    Patent number: 5994554
    Abstract: The present invention provides radiolabeled 5-{4-[2-(Methyl-pyridine-2-yl-amino)-ethoxy]-benzyl}-thiazolidine-2,4-dion e. In another aspect, the present invention provides a method for determining whether a compound does or does not interact directly with PPAR-gamma, comprising the step of specifically binding a radiolabeled compound of this invention to the ligand binding domain of PPAR-gamma.
    Type: Grant
    Filed: December 9, 1998
    Date of Patent: November 30, 1999
    Assignee: Glaxo Wellcome Inc.
    Inventors: Steven Anthony Kliewer, Jurgen M. Lehmann, Timothy M. Willson
  • Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma
    Patent number: 5902726
    Abstract: The present invention provides activator compounds, including agonists, to the peroxisome proliferator-activated receptor gamma. Particular PPAR.gamma. activators are set forth, as are a pharmaceutical composition for treating diabetes, non-insulin-dependent diabetes mellitus, cardiovascular disorders, and methods for such treatment.
    Type: Grant
    Filed: February 25, 1998
    Date of Patent: May 11, 1999
    Assignee: Glaxo Wellcome Inc.
    Inventors: Steven Anthony Kliewer, Jurgen M. Lehmann, Timothy M. Willson