Patents by Inventor Steven Armes
Steven Armes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200230069Abstract: Compositions suitable for forming an optical coating are provided, wherein the compositions include core-shell nanoparticles having (a) a core material which includes a polymer; and (b) a shell material which includes a metal oxide.Type: ApplicationFiled: April 8, 2020Publication date: July 23, 2020Inventors: Nanning Joerg ARFSTEN, Steven ARMES, Pascal Jozef Paul BUSKENS, Jens Christoph THIES, Patrick Wilhelmus Antonius VRIJALDENHOVEN
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Publication number: 20180078509Abstract: Compositions suitable for forming an optical coating are provided, wherein the compositions include core-shell nanoparticles having (a) a core material which includes a polymer; and (b) a shell material which includes a metal oxide.Type: ApplicationFiled: November 29, 2017Publication date: March 22, 2018Inventors: Nanning Joerg ARFSTEN, Steven ARMES, Pascal Jozef Paul BUSKENS, Jens Christoph THIES, Patrick Wilhelmus Antonius VRIJALDENHOVEN
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Patent number: 9855219Abstract: The present invention relates to a composition suitable for forming an optical coating, the composition comprising core-shell nanoparticles, wherein said nanoparticles comprise: (a) core material comprising polymer; and (b) shell material comprising metal oxide.Type: GrantFiled: September 5, 2007Date of Patent: January 2, 2018Assignee: DSM IP ASSETS B.V.Inventors: Nanning Joerg Arfsten, Steven Armes, Pascal Jozef Paul Buskens, Jens Christoph Thies, Patrick Wilhelmus Antonius Vrijaldenhoven
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Patent number: 9220689Abstract: Methods for the preparation of polymer-templated core-shell nanoparticles include the steps of (a) preparing a cationic polymeric core material comprising polymeric micelles, and (b) coating the core material with a silica-comprising shell by depositing the shell onto the polymeric micelles from at least one silica precursor to form the core-shell nanoparticles. Compositions which include the core-shell nanoparticles are adapted to facilitate controlled delivery of at least one active agent into a system in response to controlled changes in the pH of the system.Type: GrantFiled: October 11, 2013Date of Patent: December 29, 2015Assignee: DSM IP ASSETS B.V.Inventors: Steven Armes, Jian-Jun Yuan
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Publication number: 20150174250Abstract: The present invention is directed to a method of delivering an active agent to a locus using a polymersome containing composition. The composition comprises a plurality of polymersome vesicles and a liquid matrix. The polymersome vesicles are formed in a process which comprises a cross-linking step.Type: ApplicationFiled: June 29, 2012Publication date: June 25, 2015Applicant: RECKITT & COLMAN (OVERSEAS) LIMITEDInventors: Lee Griffiths, Malcolm Tom McKechnie, Steven Armes, Adam Blanazs
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Publication number: 20140037741Abstract: Methods for the preparation of polymer-templated core-shell nanoparticles include the steps of (a) preparing a cationic polymeric core material comprising polymeric micelles, and (b) coating the core material with a silica-comprising shell by depositing the shell onto the polymeric micelles from at least one silica precursor to form the core-shell nanoparticles. Compositions which include the core-shell nanoparticles are adapted to facilitate controlled delivery of at least one active agent into a system in response to controlled changes in the pH of the system.Type: ApplicationFiled: October 11, 2013Publication date: February 6, 2014Applicant: DSM IP ASSETS B.V.Inventors: Steven ARMES, Jian-Jun YUAN
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Patent number: 8580311Abstract: Methods for the preparation of polymer-templated core-shell nanoparticles include the steps of (a) preparing a cationic polymeric core material comprising polymeric micelles, and (b) coating the core material with a silica-comprising shell by depositing the shell onto the polymeric micelles from at least one silica precursor to form the core-shell nanoparticles. Compositions which include the core-shell nanoparticles are adapted to facilitate controlled delivery of at least one active agent into a system in response to controlled changes in the pH of the system.Type: GrantFiled: January 31, 2012Date of Patent: November 12, 2013Assignee: DSM IP Assets B.V.Inventors: Steven Armes, Jian-Jun Yuan
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Publication number: 20120128982Abstract: Methods for the preparation of polymer-templated core-shell nanoparticles include the steps of (a) preparing a cationic polymeric core material comprising polymeric micelles, and (b) coating the core material with a silica-comprising shell by depositing the shell onto the polymeric micelles from at least one silica precursor to form the core-shell nanoparticles. Compositions which include the core-shell nanoparticles are adapted to facilitate controlled delivery of at least one active agent into a system in response to controlled changes in the pH of the system.Type: ApplicationFiled: January 31, 2012Publication date: May 24, 2012Applicant: DSM IP ASSETS B.V.Inventors: Steven ARMES, Jian-Jun YUAN
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Publication number: 20100015433Abstract: The present invention relates to a composition suitable for forming an optical coating, the composition comprising core-shell nanoparticles, wherein said nanoparticles comprise: (a) core material comprising polymer; and (b) shell material comprising metal oxide.Type: ApplicationFiled: September 5, 2007Publication date: January 21, 2010Inventors: Nanning Joerg Arfsten, Steven Armes, Pascal Jozef Paul Buskens, Jens Christoph Thies, Patrick Wilhelmus Antonius Vrijaldenhoven
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Publication number: 20100009001Abstract: The invention provides a composition comprising core-shell nanoparticles, the nanoparticles comprising (a) cationic core material comprising polymer; and (b) a shell material comprising silica. Preferred core materials comprise diblock copolymer micelles comprising one block of dialkylaminoethyl methacrylate units which are partially or fully quaternised and one block of dialkylaminoethyl methacrylate units that remain non-quaternised. The invention also provides a method for the preparation of the said composition, the method involving (a) preparing a cationic core material comprising polymer; and (b) coating the core material with a shell comprising silica by treating the polymer with a silica precursor under ambient conditions. The invention also envisages a composition comprising core-shell nanoparticles which is adapted to facilitate controlled delivery of at least one active agent into a system in response to controlled changes in the pH of the system.Type: ApplicationFiled: September 5, 2007Publication date: January 14, 2010Inventors: Steven Armes, Jian-Jun Yuan
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Publication number: 20060222670Abstract: The use of a nanocomposite microgel as a stimulus responsive particulate emulsifier, wherein the microgel particles comprise an inorganic particulate component and a cross-linked responsive polymer matrix.Type: ApplicationFiled: March 31, 2005Publication date: October 5, 2006Inventors: Steven Armes, Syuji Fujii
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Publication number: 20060069203Abstract: Block copolymers comprise a core block formed of hydrophilic monomers and have pendant zwitterionic groups, and at least two terminal blocks, comprising stimulus-responsive groups. The core block has a degree of polymerisation of at least 100, whilst the terminal blocks have an average degree of polymerisation of at least 20. A solution of polymer in a liquid may be caused to change its characteristics, for instance rheology, upon being subjected to a stimulus such as a change in temperature or pH. Examples comprise core blocks formed of 2-methacryloyloxyethyl-2?-trimethylammonium ethylphosphate inner salt (MPC) and terminal blocks formed of 2-(diisopropylamino)ethyl methacrylate. Upon changing the pH from around 2 to around 8, an aqueous solution of the block copolymer gels, the solution becoming mobile again upon lowering the pH. The effect is due to deprotonation of a quaternary ammonium pendant ion to form a non-ionised group and subsequent protonation to form an ionised group.Type: ApplicationFiled: February 5, 2004Publication date: March 30, 2006Inventors: Andrew Lewis, Steven Armes, Yinghua Ma
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Publication number: 20050220880Abstract: An aqueous composition comprises an amphiphilic block copolymer, having a hydrophilic block comprising pendant zwitterionic groups and a hydrophobic block, and a biologically active compound associated with the polymer. The polymer is preferably in the form of micelles, and preferably the biological active is a hydrophobic drug, for instance having a calculated or experimentally determined logP of at least 1.0, where P is the octanol:water partition coefficient. The hydrophilic block is preferably formed from acrylic monomer including phosphoryicholine groups. The hydrophobic group is suitably formed from monomer which has groups which can be ionised at useful pH's, especially tertiary amine groups. Micelles may be formed by dissolving the block copolymer in aqueous solvent at a pH at which the amine groups are protonated then raising the pH to a value at which the amine groups are substantially deprotonated, whereupon micelles spontaneously form.Type: ApplicationFiled: March 7, 2003Publication date: October 6, 2005Inventors: Andrew Lewis, Steven Armes, Andrew Lloyd, Jonathan Salvage
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Publication number: 20050163743Abstract: Compositions are described comprising a of a block copolymer having an overall ionic charge and in which one of the blocks has pendant zwitterionic groups and a biologically active compound having a charge opposite that of the polymer. The polymer is preferably a linear diablock copolymer, preferably having a low polydispersity, such as a (tertiary amine group containing monomer) block-(zwitterionic monomer) copolymer. Suitable cationic monomers are dialkyl aminoalkyl(alk)acrylates and -acrylamides and suitable zwitterionic monomers are phosphorylcholine group containing acrylate monomers such as 2-methacyloyloxyetyl-21-trimethyl ammonium ethyl phosphate liner salt. The biologically active compound is generally polyionic and is for instance a nucleic acid, such as DNA, especially plasmid DNA.Type: ApplicationFiled: March 7, 2002Publication date: July 28, 2005Inventors: Andrew Lewis, Steven Armes
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Publication number: 20050159556Abstract: Polymers may be made from zwitterionic monomers having controlled architectures and molecular weights, using living polymerisations such as group or atom transfer radical polymerisation. For instance polymers may be formed by atom transfer radical polymerisation using a copper chloride catalyst, a ligand which is water soluble, and a water soluble tertiary alkyl halide initiator to form homopolymers having controlled polydispersities of less than 1.5 and block copolymers with other hydrophilic or hydrophobic monomers. One suitable zwitterionic monomer is 2-methacryloyloxy-2?-trimethylammoniumethyl phosphate inner salt. The block copolymers may spontaneously form micelles, believed to have zwitterionic, for instance phosphorylcholine, groups at the external surface, which may be useful as drug delivery systems with improved biocompatibility.Type: ApplicationFiled: January 3, 2005Publication date: July 21, 2005Inventors: Andrew Lewis, Sean Willis, Steven Armes, Emma Lobb, Yinghua Ma