Patents by Inventor Steven B. Baim

Steven B. Baim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Eukaryotic cells comprising a DNA sequence encoding a bacterial-viral chimeric transactivator protein
    Patent number: 5674730
    Abstract: The present invention relates to novel chimeric transactivating proteins comprising a functional portion of a DNA binding protein and a functional portion of a transcriptional activator protein. The chimeric transactivating proteins of the invention offer a variety of advantages, including the specific activation of expression of genes engineered to comprise transactivator responsive elements, thereby achieving exceptionally high levels of gene expression. Furthermore, in various embodiments of the invention, the transactivator proteins may be used to increase expression of some genes while repressing the expression of others, thus permitting a greater degree of control of gene expression patterns than other currently available systems. In preferred embodiments of the invention, the function of the chimeric transactivator proteins may be induced, for example, by chemical agents (e.g. IPTG) or changes in temperature.
    Type: Grant
    Filed: March 30, 1993
    Date of Patent: October 7, 1997
    Assignee: The Trustees of Princeton University
    Inventors: Steven B. Baim, Mark A. Labow, Thomas E. Shenk, Arnold J. Levine