Abstract: Provided are methods, compositions, and kits for improving a delivery of a nucleic acid to a cell in an organ of a subject. Such methods, compositions, and kits may include a sonoactive agent and a nucleic acid comprising a cargo polynucleotide and a nuclear localization element and/or an innate immune response avoidance moiety, which may be an aptamer. Delivery may involve sonoporation.

Abstract: A shower curtain having one or more pockets formed near the lower edge and on the side facing the shower nozzle is disclosed. The pockets are designed to collect water while the shower is in use. The pockets have drain holes that allow the water to slowly drain, such that while the shower is in use, the pockets will fill, but when the shower is shut off, the pockets will slowly drain until they are empty. The pockets are in fluid communication with one another by way of openings extending between the pockets. The bottom edge of the pocket is sloped with the highest point of the bottom wall at or near the center of the shower curtain encouraging water to flow toward the edges. Below the pockets, the shower curtain is formed of an air permeable material such as nylon mesh.

Abstract: An ultrasonic imaging agent is formed by subjecting an aqueous protein solution to high frequency sonication while heating the solution sufficiently to denature portions of the protein, thereby forming a dispersion of microbubbles stabilized by denatured protein. In a preferred embodiment, the protein solution is formed from human serum albumin, and the formed microbubbles have a relatively uniform size in the 2 to 5 micron range, suitable for imaging of pulmonary or small organ vasculature.

Abstract: A method of ultrasonic imaging for use in medical procedures is disclosed. The method comprises providing specifically defined microbubbles formed by sonicating a bicompatible liquid comprising a sonicated aqueous protein solution, preferably a 5% solution of human serum albumin, and denaturing the protein therein by heat or chemical methods; injecting the microbubbles into an animal or human to thereby alter the acoustic properties of an area to be imaged; and then ultrasonically scanning the area so as to obtain an ultrasound scanning image.

Abstract: A method of ultrasonic imaging for use in medical procedures is disclosed. The method comprises injecting specifically defined microparticles or sonicated microbubbles into an animal or human to thereby alter the acoustic properties of an area to be imaged, and then ultrasonically scanning the area so as to obtain an image.