Abstract: The present invention provides methods of optimizing certain stable liquid formulations of antibodies that immunospecifically bind to antigens of interest. Such formulations are suitable for parenteral administration to a subject, and exhibit increased stability, low to undetectable levels of aggregation, low to undetectable levels of antibody fragmentation/degradation, and very little to no loss of the biological activities of the antibodies, even during long periods of storage. The methods of the invention provide formulations that offer multiple advantages over formulations produced by non-optimized methods, including less stringent or more readily available transportation and storage conditions, less frequent dosing, and/or smaller dosage amounts in the therapeutic, prophylactic and diagnostic uses of such formulations. The invention further provides methods of identifying antibodies exhibiting certain phase behaviors such that the antibodies can be formulated by the methods of the invention.

Abstract: An information display system for a vehicle includes an information display for displaying a plurality of selectable information display levels according to an information display hierarchy. Each selectable information display level may include one or more visual gauges for conveying vehicle information. Each successive selectable information display level may include additional and/or alternative vehicle information when compared to the preceding selectable information display level. The information display system further includes a controller configured to display the plurality of selectable information display levels according to an at least one driver input. In this way, the information display can display a particular selectable information display level best suited to a driver's individual preferences or understanding of the vehicle's operations.

Abstract: A pharmaceutical delivery device with triggered automatic needle insertion and manually controlled pharmaceutical injection.

Abstract: Disclosed are laminated articles comprising a first polymer layer and a second polymer layer having an inclusion embedded between the layers, wherein at least one layer comprises a branching agent to improve dimensional stability during the lamination process. Disclosed are laminated articles comprising a first polymer layer and a second polymer layer having an inclusion embedded between the layers, wherein at least one layer comprises a copolyester comprising a branching agent to improve dimensional stability during the lamination process. Also disclosed are methods of laminating a first layer and a second layer with an inclusion between the layers to form a laminated article with an embedded inclusion, wherein at least one layer comprises a copolyester comprising a branching agent.

Abstract: The present invention is a system for discouraging the recording of a video image on a video recorder of a movie projected onto a display surface of a translucent movie screen. The system includes a plurality of IR projector lamps mounted behind the movie screen and adjacent to a back surface of the screen opposite the display surface. Each of the projector lamps is adapted and configured to generate an IR beam sufficient strong to transmit through the movie screen with sufficient intensity to create a bright spot of IR light on the display surface corresponding to the position of the IR projectors. The IR projectors are further adapted and configured such that the bright spots of IR light are sufficiently bright to appear clearly on the recorded video image. The IR projectors are releasably coupled to a control module contained in a housing via a plurality of connector elements and electrical lines.

Abstract: A method and apparatus for administering a pharmaceutical. The method employs a delivery device including a housing, a pharmaceutical containing needled syringe movable within the housing, an activation button disposed at one of the housing, and wherein the housing is flared radially outward at the other end and designed to allow visibility of the needled syringe. A skin-contacting surface of the housing at the flared end is designed to limit slippage along the skin, and at least one injection targeting guide is provided.

Abstract: In one aspect the present invention relates to a method of making an encapsulated electrically energized device, the method comprising: providing a first layer and a second layer each independently comprising a copolyester, providing the electrically energized between the first and second layer, thermocompressively fusing the first layer and the second layer to encapsulate the electrically energized device by applying pressure at a temperature sufficient to form the article, wherein the temperature at an interface between the first and second layers is equal to or greater than Tg of the first layer and the second layer, and wherein the polyester layers have a flow during encapsulation less than the flow that induces fractures in the electrically energized device.

Abstract: The present invention provides formulations of proteins comprising a variant Fc region that improve the stability in part by reducing the propensisty of such molecules to rapidly aggregate. The invention provides both liquid and lyophilized formulations either of which can be utilized to generate a high protein concentration liquid suitable for administration to a subject. The invention further provides methods of utilizing the formulations of the present invention for therapeutic or prophylactic treatment of diseases and disorders or for diagnostic purposes.

Abstract: A system includes a board having opposing surfaces and at least one leg connected to one surface of the board through a first pivotable fitting to allow the board and the leg to move between a first position wherein the board and the leg are substantially parallel and a second position wherein the board and the leg are substantially perpendicular. The system also includes a locking mechanism secured to the board through a second pivotable fitting at a first end and configured to rotate at a second end opposite the first end between a storage position extending parallel with the board and a work position extending perpendicular to the board.

Abstract: A method and apparatus for cleaning residue from components of an ion source region of an ion implanter used in the fabrication of microelectronic devices. To effectively remove residue, the components are contacted with a gas-phase reactive halide composition for sufficient time and under sufficient conditions to at least partially remove the residue. The gas-phase reactive halide composition is chosen to react selectively with the residue, while not reacting with the components of the ion source region or the vacuum chamber.