Abstract: A plasmonic nanostructure for enhanced light excitation is disclosed. The plasmonic nanostructure includes a substrate, an adhesion layer disposed on top of the substrate, a surface plasmon resonance layer, and a cavity that extends into the surface plasmon resonance layer. The surface plasmon resonance layer is configured to concentrate an applied plasmon field to a bottom portion of the cavity.

Abstract: 6,7-Dihydro-5H-cyclopenta[b]pyridine and 5,6,7,8-tetrahydroquinoline compounds of Formula (I), including salts, hydrates and solvates thereof, that act as 5-HT2 receptor ligands and their uses in the treatment of diseases linked to the activation of 5-HT2c receptors are described herein.

Abstract: Methods of building surface amplification devices are disclosed. Methods and devices for detecting target nucleic acids are also disclosed. Primer pairs are seeded on the surface of a substrate using a connecting compound between the primers to optimize the distance between immobilized primers. The flexible linking compounds avoid the need to bend extension products during later amplifications.

Abstract: Described are methods and systems for acquiring real-time quantified melt data. A first Double-stranded nucleic acid are immobilized on a support. The temperature of the double-stranded nucleic acids is slowly ramped up until the double-stranded nucleic acids melt. Differences in fluorescence emission are used to signal when the melt occurred. An evanescent field is used to generate fluorescence emission.

Abstract: Described are methods and devices for immobilizing primers on the surface of a microarray with polymer linkers. Nucleic acid amplification and total analysis without the necessity of polymerase chain reaction may be accomplished with the disclosed methods and devices.

Abstract: A crustless sandwich made from two slices of baked bread. The sandwich includes first and second matching crustiess bread pieces. The bread pieces have the same general outer shape defined by an outer periphery with central portions surrounded by an outer peripheral area, the bread pieces being at least partially crimped together at the outer peripheral area. A central composite food layer is positioned between the central portions of the bread pieces and spaced inwardly of the crimped outer periphery area. The composite food layer includes a first and second layer of a first food spread and a second food spread that is substantially encapsulated between the first and second layer of the first food spread. The first food spread is nutritionally enhanced.

Abstract: The invention relates to a method of generating an image of an animate human or non-human animal body or part thereof. The method comprises administering to said body a physiologically tolerable contrast agent comprising a radiation absorbing component and/or a pressure inducing component, exposing said body to radiation, detecting pressure waves generated in said body by said radiation and generating an optoacoustic image therefrom of at least a part of said body containing the administered contrast agent.

Abstract: A cryptographic-enabled messaging system providing a “Policy Management Agent” is described. The Policy Management Agent works in conjunction with a standard mail server, such as an SMTP (Simple Mail Transport Protocol) mail server, to ensure that incoming and outgoing e-mail adheres to the policies that are specified for a given site. Specifically, the Agent intercepts e-mail normally bound for the mail server and checks to make sure that it conforms with policies configured for one's site (e.g., corporate site). If the e-mail adheres to the policies for the site, it is forwarded to the mail server where it is routed to the intended recipient. If the e-mail does not adhere to the policies specified for the site, a message of one's choosing is sent to the client indicating that the e-mail was rejected. In an exemplary embodiment (e.g.

Abstract: A apparatus and process for ablating a matrix of high density vias in a flexible substrate. The apparatus is cantilevered on a horizontal shelf from a partition where it can be rigidly supported. A vacuum container reciprocates towards and away from the partition and supports the horizontal shelf by permitting supporting casters to bear on and be supported by the reciprocating container. When the container is away from the partition, servicing of the apparatus as well as the insertion an removal of substrate can occur. When the container is adjoined to the partition, a vacuum can be drawn on the apparatus and processing commenced. A continuous flexible substrate is provided extending in a circuitous path between a supply roll and a take up roll, all interior of the container. The flexible substrate is maintained under constant tension and incrementally advanced. The substrate is incrementally advanced and stopped, passing across a table.