Patents by Inventor Steven Bloembergen

Steven Bloembergen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190374469
    Abstract: A delivery device for an active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders. The nanoparticles may be made by applying a high shear force in the presence of a crosslinker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water. The biopolymer may be functionalized. The aptamer may be conjugated directly to the cross-linked biopolymers. The active agent may be a drug useful for the treatment of cancer. The delivery device survives for a period of time in the body sufficient to allow for the sustained release of a drug and for the transportation and uptake of the conjugate into targeted cells. However, the biopolymer is biocompatible and resorbable.
    Type: Application
    Filed: April 15, 2019
    Publication date: December 12, 2019
    Inventors: Steven Bloembergen, Ian J. McLennan, Nathan Jones, Ryan Wagner, Aareet Ganesh Shermon, Abdel Rahman Elsayed, Juewen Liu
  • Publication number: 20190298660
    Abstract: This specification describes a nanoparticle delivery agent for drugs such as chemotherapy drugs. Starch nanoparticles are internally crosslinked by a phosphate crosslinker such as sodium trimetaphosphate (STMP) using a phase inversion emulsion process. The particle size may be in the range of 80-500 nm. A wide variety of organic phosphates are present apart from the phosphodiester crosslinking. These included triphosphates, monophosphates and diphosphates. The nanoparticles are hydrogels and retain significant amounts of water when dispersed in solution possibly due to the electrostatic repulsion between the chains within the nanoparticle. The nanoparticles are, in general, non-toxic, for example to HeLa cancer cells. The nanoparticles display a high drug loading, with a maximum seen with about 20-40 mol % STMP. Drug release occurs more readily at lower pH. Exposure to typical cell culture environments induces significant release of drug compared to simple buffer environments.
    Type: Application
    Filed: April 23, 2019
    Publication date: October 3, 2019
    Inventors: Steven Bloembergen, Anand Francis Lopez, Juewen LIU
  • Patent number: 10285943
    Abstract: A delivery device for an active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders. The nanoparticles may be made by applying a high shear force in the presence of a crosslinker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water. The biopolymer may be functionalized. The aptamer may be conjugated directly to the cross-linked biopolymers. The active agent may be a drug useful for the treatment of cancer. The delivery device survives for a period of time in the body sufficient to allow for the sustained release of a drug and for the transportation and uptake of the conjugate into targeted cells. However, the biopolymer is biocompatible and resorbable.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: May 14, 2019
    Assignee: GreenMark Biomedical Inc.
    Inventors: Steven Bloembergen, Ian J. McLennan, Nathan Jones, Ryan Wagner, Aareet Krsna Ganesh Shermon, Abdel Rahman Elsayed, Juewen Liu
  • Publication number: 20170342302
    Abstract: A binder comprising isocyanate droplets in water, wherein the isocyanate droplets have an average droplet size of 500 microns or less, and the isocyanate droplets have shells comprising a biopolymer or a reaction product of a biopolymer and isocyanate. The biopolymer may be a biopolymer nanoparticle or cooked and chemically modified starch. Optionally, the binder may also include urea. The substrate for the binder may be wood, another lignocellulosic material, or synthetic or natural fibers. In particular examples, the binder is used to make no added formaldehyde wood composites including particle board and MDF.
    Type: Application
    Filed: April 30, 2015
    Publication date: November 30, 2017
    Inventors: Somaieh Salehpour, J. Douglas Ireland, Niels M.B. Smeets, Steven Bloembergen
  • Publication number: 20170298227
    Abstract: A binder has at least one isocyanate and at least one biopolymer mixed with water. The biopolymer may be a biopolymer nanoparticle or cooked and chemically modified starch. Optionally, the binder may also include urea. The biopolymer and water are mixed, and the isocyanate is added to the mixture. The binder may have a viscosity that is suitable for being sprayed on a substrate to make a composite material, for example a viscosity of 700 cP or less or 500 cP or less at 40° C. The substrate may be wood, another lignocellulosic material, or synthetic or natural fibers. In particular examples, the binder is used to make no added formaldehyde wood composites including particle board and fiberboard. Alternatively, the binder may have a higher viscosity and be used to make plywood.
    Type: Application
    Filed: June 29, 2017
    Publication date: October 19, 2017
    Inventors: Somaieh Salehpour, J. Douglas Ireland, Niels M. B. Smeets, Steven Bloembergen
  • Patent number: 9662824
    Abstract: A process for producing a biopolymer nanoparticles product is disclosed. In this process, biopolymer feedstock and a plasticizer are fed to a feed zone of an extruder having a screw configuration in which the feedstock is process using shear forces in the extruder, and a crosslinking agent is added to the extruder downstream of the feed zone. The biopolymer feedstock and plasticizer are preferably added separately to the feed zone. The screw configuration may include two or more steam seal sections. Shear forces in a first section of the extruder may be greater than shear forces in an adjacent second section of the extruder downstream of the first section. In a post reaction section located after a point in which the crosslinking reaction has been completed, water may be added to improve die performance.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: May 30, 2017
    Assignee: EcoSynthetix Ltd.
    Inventors: Robert H. Wildi, Edward Van Egdom, Steven Bloembergen
  • Patent number: 9580846
    Abstract: A curable aqueous binder composition comprising sheared or extruded cross linked starch particles and a crosslinking agent for use in the formation of composite materials such as mineral, natural organic or synthetic fiber products including mineral fiber insulation, non-woven mats, fiberglass insulation and related glass fiber products as well as wood based products and construction materials. In one application the curable aqueous starch binder composition may be blended with a second non-formaldehyde resin to make fiberglass insulation. In another application the curable aqueous starch binder composition may be mixed into a formaldehyde based resin to make fiberglass roof shingles.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: February 28, 2017
    Assignee: EcoSynthetix Ltd.
    Inventors: Alexander Tseitlin, David Van Alstyne, Steven Bloembergen
  • Publication number: 20170029549
    Abstract: Methods of producing a latex, and the resulting latexes, are described herein. Bio-based colloidal particles are used in a free radical polymerization process. The particles may provide one or more of a seed particle, stabilizing agent, Pickering emulsifier, surfactant or co-monomer. Optionally, the particles (or biopolymer molecules such as starch in the particles) are functionalized, for example to provide double bonds or free radicals, prior to or while conducting a free radical polymerization reaction including the particles and a second compound which is a monomer. In another option, the particles are used in the presence of a functionalizing agent (capable for example of providing double bonds or free radicals on a biopolymer) in a free radical polymerization reaction. Optionally, the resulting latex may include particles of a mixed morphology including a bio-based phase.
    Type: Application
    Filed: October 12, 2016
    Publication date: February 2, 2017
    Inventors: Steven BLOEMBERGEN, Jan VAN LEEUWEN, Niels Mathieu Barbara SMEETS, Vahid NOEEI ANCHEH, Julien Francois Marie Antoine Philippe MESNAGER, Do Ik LEE
  • Publication number: 20160297983
    Abstract: This patent describes formaldehyde free or formaldehyde reduced binders useful, for example, in a fiber based composite material such as glass or other mineral fiber insulation, non-woven fabric or wood-based board. In one example, melamine is used as an acidic solution or a salt. The salt or solution is used to create an aqueous binder with other components such as a polyol and a crosslinker. A preferred polyol is a nanoparticle comprising high molecular weight starch. In other examples, binders include mixtures of a polyol with urea and a crosslinker. In other examples, a multi-component nanoparticle is made by reacting a polyol such as starch in an extruder with an insolubilizer such as melamine or urea. The resulting particles are mixed with water, optionally with other components such as an additional crosslinker, to create an aqueous binder.
    Type: Application
    Filed: December 5, 2013
    Publication date: October 13, 2016
    Inventors: Uttam Kumar SAHA, Steven BLOEMBERGEN
  • Publication number: 20160194527
    Abstract: This specification relates to cold-set biobased adhesive compositions, comprising aqueous formulations of biopolymers, optionally with alkaline additives, optionally fortified with high-aspect-ratio inorganic and organic fillers, fibers and nanofibers, optionally with barrier-inducing additives. The adhesive may be used, for example, as a cold-set, preferably biobased, laminating adhesive. In particular, the laminating adhesive may be used to create liner and/or medium paperboard products for light-weight paperboard and corrugated boxboard materials that, in some examples, have enhanced strength and/or barrier properties as compared with similar weight paperboard products. These laminated paperboard and corrugated boxboard materials are used, for example, as light weight packaging materials that are compatible with paper recycling and composting operations. In the context of this abstract, the term “lamination” or “laminating” relates to the adhesion of two flat (rather than pre-corrugated) paper surfaces, i.
    Type: Application
    Filed: January 4, 2016
    Publication date: July 7, 2016
    Inventors: Steven BLOEMBERGEN, Charles P. KLASS
  • Patent number: 9157187
    Abstract: The invention therefore provides a method of improving print performance in a paper product including applying a coating composition having (i) a pigment and (ii) a starch dispersion of discrete crosslinked native starch particles in an aqueous liquid, wherein the particle size of the starch particles in the starch dispersion ranges from about 40 nm to about 400 ?m, to the paper product, wherein the print performance of the paper product is improved. In one embodiment, the coating composition includes a solids content of from 5 to about 75% weight and includes (i) about 100 parts by weight of pigment, and (ii) about 1 to about 300 parts by weight of starch, all based on dry weight.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: October 13, 2015
    Assignee: ECOSYNTHETIX LTD.
    Inventor: Steven Bloembergen
  • Patent number: 9080290
    Abstract: The present invention provides the novel and nonobvious discovery that sugar macromers can be effectively used to provide a new generation of renewable comonomers for bio-synthetic hybrid paper binder systems having a controlled hydrophilic-hydrophobic balance for improved water retention and film forming properties, on machine runnability, offset printability, biodegradability, enhanced recyclability, and other performance attributes.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: July 14, 2015
    Assignee: ECOSYNTHETIX LTD.
    Inventors: Steven Bloembergen, Ian J. McLennan, Do Ik Lee
  • Patent number: 9011741
    Abstract: In a process for producing a biopolymer nanoparticles, biopolymer feedstock and a plasticizer are fed to a feed zone of an extruder and the biopolymer feedstock is processed using shear forces. A crosslinking agent is added to the extruder downstream of the feed zone. The process has a production rate of at least 1.0 metric tons per hour. The feedstock and the plasticizer are preferably added separately to the feed zone. The extruder may have single flight elements in the feed zone. The temperatures in the intermediate section of the extruder are preferably kept above 100 C. The screw configuration may include two or more steam seal sections. Shear forces in a first section of the extruder may be greater than shear forces in an adjacent downstream section of the first section. In a post reaction section, water may be added to improve die performance.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: April 21, 2015
    Assignee: EcoSynthetix Ltd.
    Inventors: Robert H. Wildi, Edward Van Egdom, Steven Bloembergen
  • Publication number: 20150025029
    Abstract: A delivery device for a active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders, such as cancer. The delivery device survives for a period of time in the body sufficient to allow for transport and uptake of the delivery device into targeted cells. The degree of crosslinking can provide a desired release profile of the active agent at, near or inside the target cells. The nanoparticles may be made by applying a high shear force in the presence of a cross linker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water.
    Type: Application
    Filed: September 21, 2012
    Publication date: January 22, 2015
    Inventors: Steven Bloembergen, Ian J. McLennan, Nathan Jones, Areet Krsna Ganesh Shermon, Abdel Elsayed, Juewen Liu
  • Publication number: 20140295090
    Abstract: A curable aqueous binder composition comprising sheared or extruded cross linked starch particles and a crosslinking agent for use in the formation of composite materials such as mineral, natural organic or synthetic fibre products including mineral fibre insulation, non-woven mats, fibreglass insulation and related glass fibre products as well as wood based products and construction materials. In one application the curable aqueous starch binder composition may be blended with a second non-formaldehyde resin to make fibreglass insulation. In another application the curable aqueous starch binder composition may be mixed into a formaldehyde based resin to make fibreglass roof shingles.
    Type: Application
    Filed: June 4, 2012
    Publication date: October 2, 2014
    Inventors: Alexander Tseitlin, David Van Alstyne, Steven Bloembergen
  • Publication number: 20130337065
    Abstract: A delivery device for an active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders. The nanoparticles may be made by applying a high shear force in the presence of a crosslinker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water. The biopolymer may be functionalized. The aptamer may be conjugated directly to the cross-linked biopolymers. The active agent may be a drug useful for the treatment of cancer. The delivery device survives for a period of time in the body sufficient to allow for the sustained release of a drug and for the transportation and uptake of the conjugate into targeted cells. However, the biopolymer is biocompatible and resorbable.
    Type: Application
    Filed: December 2, 2011
    Publication date: December 19, 2013
    Applicant: ECOSYNTHETIX LTD.
    Inventors: Steven Bloembergen, Ian J. McLennan, Nathan Jones, Ryan Wagner, Aareet Ganesh Shermon, Abdel Rahman Elsayed, Juewen Liu
  • Publication number: 20130281608
    Abstract: The present invention provides the novel and nonobvious discovery that sugar macromers can be effectively used to provide a new generation of renewable comonomers for bio-synthetic hybrid paper binder systems having a controlled hydrophilic-hydrophobic balance for improved water retention and film forming properties, on machine runnability, offset printability, biodegradability, enhanced recyclability, and other performance attributes.
    Type: Application
    Filed: October 7, 2011
    Publication date: October 24, 2013
    Applicant: ECOSYNTHETIX LTD.
    Inventors: Steven Bloembergen, Ian J. McLennan, Do Ik Lee
  • Publication number: 20130239849
    Abstract: The present invention provides novel biolatex conjugate compositions and methods of production and use thereof. The novel biolatex conjugate compositions comprise a biopolymer-additive complex (prepared by co-extruding a biopolymer feedstock, at least one performance-enhancing additive, and at least one plasticizer under shear forces) reacted with a crosslinking agent under shear forces. The biolatex conjugate compositions exhibit enhanced performance properties for coated paper, paperboard, and other applications using extremely low levels of performance-enhancing additives.
    Type: Application
    Filed: May 9, 2013
    Publication date: September 19, 2013
    Applicant: EcoSynthetix Ltd.
    Inventors: Steven BLOEMBERGEN, Do I. LEE, Ian J. MCLENNAN, Robert H. WILDI, Edward VAN EGDOM
  • Publication number: 20130090467
    Abstract: A delivery device for an active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders. The nanoparticles may be made by applying a high shear force in the presence of a crosslinker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water. The biopolymer may be functionalized. The aptamer may be conjugated directly to the cross-linked biopolymers. The active agent may be a drug useful for the treatment of cancer. The delivery device survives for a period of time in the body sufficient to allow for the sustained release of a drug and for the transportation and uptake of the conjugate into targeted cells. However, the biopolymer is biocompatible and resorbable.
    Type: Application
    Filed: September 13, 2012
    Publication date: April 11, 2013
    Applicant: ECOSYNTHETIX LTD.
    Inventors: Steven BLOEMBERGEN, Ian J. MCLENNAN, Nathan JONES, Ryan WAGNER, Aareet Krsna GANESH SHERMON, Abdel Rahman ELSAYED, Juewen LIU
  • Publication number: 20130062807
    Abstract: In a process for producing a biopolymer nanoparticles, biopolymer feedstock and a plasticizer are fed to a feed zone of an extruder and the biopolymer feedstock is processed using shear forces. A crosslinking agent is added to the extruder downstream of the feed zone. The process has a production rate of at least 1.0 metric tons per hour. The feedstock and the plasticizer are preferably added separately to the feed zone. The extruder may have single flight elements in the feed zone. The temperatures in the intermediate section of the extruder are preferably kept above 100 C. The screw configuration may include two or more steam seal sections. Shear forces in a first section of the extruder may be greater than shear forces in an adjacent downstream section of the first section. In a post reaction section, water may be added to improve die performance.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 14, 2013
    Applicant: ECOSYNTHETIX LTD.
    Inventors: Robert H. Wildi, Edward Van Egdom, Steven Bloembergen