Abstract: This invention relates to methods of selecting or tailoring a therapeutic for an individual subject, reducing the excipient burden in a subject, and identifying adverse reaction-associated inactive ingredients in a subject being administered multiple drugs. The invention also relates to methods of inhibiting UGT2B7 activity or P-gp activity, methods of treating a subject via co-administration of a UGT2B7 inhibitor or a P-gp inhibitor, and pharmaceutical compositions comprising gum rosin, abietic acid, or vitamin A palmate.

Abstract: A topical ophthalmic pharmaceutical formulation may include particles of the compound (2S,3S,4R)—N?-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N?-benzylguanidine suspended in a solution comprising monobasic sodium phosphate monohydrate, disodium phosphate heptahydrate, edetate disodium, benzalkonium chloride, sodium chloride, polysorbate 80, and water. A method of treating glaucoma may include topically applying to the eye of a patient in need thereof a therapeutically effective amount of this formulation.

Abstract: Disclosed herein are pharmaceutical formulations comprising particles of formula 1: wherein R1, R2, R3, R4, R5, R6, n and * are each defined in specification. Also disclosed are methods of decreasing intraocular pressure comprising topically applying a benzopyranyl guanidine derivative of formula 1 to an eye.

Abstract: A ride vehicle includes a tactile or physical contact system. The ride vehicle moves along a path or track. The path or track can be outdoors or partially or entirely indoors, i.e., in a dark ride. The system provides a touch effect by causing a physical or solid touch element to make physical contact with a part of a rider's body. Alternatively, the system can operate by projecting or spraying a gas, such as air, a vapor, such as water vapor or steam, or even a liquid, such as water, toward or onto part of a rider's body or the rider's clothing. The system is advantageously substantially self-contained aboard the vehicle, but may receive power or working fluid from off-board sources, either at discrete locations, or continuously along the ride path.

Abstract: A personalized audio system for an amusement ride includes an audio selection system, a guest identification system and a ride vehicle enabled to reproduce audio selections made using the selection system in a specific seat of the ride vehicle corresponding to the seat occupied by the guest who selected the audio during that guest's ride on the amusement ride.

Abstract: A waterfall effect for an amusement ride has a diverter system for creating a gap through a waterfall curtain timed to closely coincide with the arrival of a ride vehicle for providing a simulated effect of crashing through the waterfall curtain.

Abstract: An amusement ride has a track defining a ride vehicle path with a section of the track that can be decoupled from the main track and is subsequently movable on or about up to three axes with between one and six independent degrees of freedom.

Abstract: A ride vehicle includes a tactile or physical contact system. The ride vehicle moves along a path or track. The path or track can be outdoors or partially or entirely indoors, i.e., in a dark ride. The system provides a touch effect by causing a physical or solid touch element to make physical contact with a part of a rider's body. Alternatively, the system can operate by projecting or spraying a gas, such as air, a vapor, such as water vapor or steam, or even a liquid, such as water, toward or onto part of a rider's body or the rider's clothing. The system is advantageously substantially self-contained aboard the vehicle, but may receive power or working fluid from off-board sources, either at discrete locations, or continuously along the ride path.