Abstract: Methods for biological sample multi-color light detection using color-image detectors with pixel filter arrays or multi-color pixels.

Abstract: A system is provided that can comprise: at least two excitation sources, each adapted to provide a different excitation wavelength than at least one other; at least one detector; and a plurality of spectrally resolvable dyes. A set of dyes is also provided and can comprise one or more energy transfer dyes and each energy transfer dye can include two or more fluorescence resonance energy transfer dye moieties linked together. A set of energy transfer dyes is also provided wherein each energy transfer dye of the set comprises a different donor dye moiety than the other energy transfer dyes of the set, and the same acceptor dye moiety as the other energy transfer dyes of the set. A method of detection using the system is also provided.

Abstract: Systems and methods for biological sample detection by combining and directing light with an optical blender that provides a composite beam from spatially and spectrally distinct non-parallel light sources.

Abstract: Methods and optical systems for scanning of a target sample, including methods and systems using a low mass scan head. The present invention also relates to methods and systems for performing sample assays, and for producing and measuring optical responses and signatures.

Abstract: A luminescence detection system may include an excitation light source, a single element achromat, and a detector. The single element achromat may be configured to regulate the excitation light from the light source and direct the regulated light to a target, and the detector may be configured to detect luminescence generated by the target. The single element achromat may be configured to regulate the emission light from the target and direct the regulated light to a detector, and the excitation light source may be configured to direct the excitation light to the target. The single element achromat may be configured to regulate both the excitation light from the light source and the emission light from the target and direct the regulated light to, respectively, the target and a detector.

Abstract: The invention relates to an optical detection system for a thermal cycling device including at least one light source, a light detection device for detecting light received from a plurality of biological samples, and a lens having first and second surfaces formed on the lens, the second surface substantially opposed to the first surface. The first surface may be configured to collimate light and the second surface may be configured to direct light into each of the plurality of biological samples.

Abstract: An optical device adapted to detect fluorescence from a biological sample. The optical device includes an optical relay to collect fluorescence emitted by the fluorophores and to direct the collected fluorescence towards a detector.

Abstract: A fluorometry device and method adapted to determine concentration of spectrally distinguishable species in a biological sample with a plurality of movable optical devices.

Abstract: The invention relates to an optical detection system for a thermal cycling device including at least one light source, a light detection device for detecting light received from a plurality of biological samples, and a lens having a plurality of focusing lens segments greater than the plurality of biological samples to direct light into the plurality of biological samples.

Abstract: A fluorometry device and method adapted to determine concentration of spectrally distinguishable species in a biological sample with a plurality of movable optical devices.

Abstract: An optical imaging system with a first imaging lens, a field stop, and a second imaging lens configured to reduce the amount of dead space between images of samples.