Patents by Inventor Steven Brem

Steven Brem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Edema invariant tractography
    Patent number: 10481233
    Abstract: Edema invariant tractography methods are provided. The methods include acquiring data using a multishell, high angular resolution diffusion imaging sequence; (ii) modeling the data using a multi-compartment model; and (iii) reconstructing the fibers through a probabilistic tracking algorithm using a fiber orientation distribution which has streamlines fitted to the output of said probabilistic tracking algorithm.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: November 19, 2019
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Ragini Verma, Luke Macyszyn, Emmanuel Caruyer, Jeremy Lecoeur, Mark Elliot, Steven Brem
  • EDEMA INVARIANT TRACTOGRAPHY
    Publication number: 20170285124
    Abstract: Edema invariant tractography methods are provided. The methods include acquiring data using a multishell, high angular resolution diffusion imaging sequence; (ii) modeling the data using a multi-compartment model; and (iii) reconstructing the fibers through a probabilistic tracking algorithm using a fiber orientation distribution which has streamlines fitted to the output of said probabilistic tracking algorithm.
    Type: Application
    Filed: September 8, 2015
    Publication date: October 5, 2017
    Inventors: Ragini Verma, Luke Macyszyn, Emmanuel Caruyer, Jeremy Lecoeur, Mark Elliot, Steven Brem
  • Method of rapidly visualizing essential neural pathways
    Patent number: 8788015
    Abstract: A method of optimizing pre-operative procedures in the field of neurosurgery. The method facilitates the identification of essential fiber tract pathways that must be avoided when planning and performing an operation, thereby increasing surgical safety and avoiding complications. The method includes the combined use of four variables in Diffusion Tensor Imaging (DTI)-Fiber Tracking (FT) of projection fibers in the brain. These variables include Jain-Brem™ fractional anisotropy constant for tractography (JB-FACT), Jain-Brem™ fiber length (JB-FL), subcentimeter size placement of regions of interest (ROI), and the placement of ROIs to cover the anatomical pathway of projection fibers. JB-FACT and JB-FL provide rapid, reproducible tracking for projection fibers in the brain.
    Type: Grant
    Filed: February 6, 2012
    Date of Patent: July 22, 2014
    Assignee: University of South Florida
    Inventors: Surbhi Jain, Steven Brem
  • Methods of predicting high grade gliomas using senescence associated genes
    Patent number: 8741575
    Abstract: The present invention relates to biomarkers for neoplasias such as high grade gliomas. The inventors have discovered that the overexpression of senescence associated genes (SAG) is associated with a poor prognosis in subjects with high grade gliomas. The present invention provides SAG biomarkers for predicting response to therapy for subjects having high grade glioma based on dividing the samples into high and low risk groups; diagnosing high grade glioma; monitoring progression of high grade glioma from one biological state to another; and determining efficacy of treatment for high grade gliomas.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: June 3, 2014
    Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.
    Inventors: Domenico Coppola, Dung-Tsa Chen, Steven Brem
  • METHODS OF PREDICTING HIGH GRADE GLIOMAS USING SENESCENCE ASSOCIATED GENES
    Publication number: 20120322687
    Abstract: The present invention relates to biomarkers for neoplasias such as high grade gliomas. The inventors have discovered that the overexpression of senescence associated genes (SAG) is associated with a poor prognosis in subjects with high grade gliomas. The present invention provides SAG biomarkers for predicting response to therapy for subjects having high grade glioma based on dividing the samples into high and low risk groups; diagnosing high grade glioma; monitoring progression of high grade glioma from one biological state to another; and determining efficacy of treatment for high grade gliomas.
    Type: Application
    Filed: August 29, 2012
    Publication date: December 20, 2012
    Applicant: H. Lee Moffitt Cancer Center and Research Institute, Inc.
    Inventors: Domenico Coppola, Dung-Tsa Chen, Steven Brem
  • METHOD OF RAPIDLY VISUALIZING ESSENTIAL NEURAL PATHWAYS
    Publication number: 20120172705
    Abstract: A method of optimizing pre-operative procedures in the field of neurosurgery. The method facilitates the identification of essential fiber tract pathways that must be avoided when planning and performing an operation, thereby increasing surgical safety and avoiding complications. The method includes the combined use of four variables in Diffusion Tensor Imaging (DTI)-Fiber Tracking (FT) of projection fibers in the brain. These variables include Jain-BremTM fractional anisotropy constant for tractography (JB-FACT), Jain-BremTM fiber length (JB-FL), subcentimeter size placement of regions of interest (ROI), and the placement of ROIs to cover the anatomical pathway of projection fibers. JB-FACT and JB-FL provide rapid, reproducible tracking for projection fibers in the brain.
    Type: Application
    Filed: February 6, 2012
    Publication date: July 5, 2012
    Applicants: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., UNIVERSITY OF SOUTH FLORIDA
    Inventors: Surbhi Jain, Steven Brem