Patents by Inventor Steven Brentano

Steven Brentano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190119742
    Abstract: The present disclosure provides compositions, methods and systems for quantifying target sequences and identifying target sequence variants.
    Type: Application
    Filed: April 6, 2017
    Publication date: April 25, 2019
    Applicant: OMNIOME, INC.
    Inventors: Yi ZHANG, Steven BRENTANO, Eugene TU, Kandaswamy VIJAYAN
  • Publication number: 20080090246
    Abstract: The present invention concerns oligonucleotides containing one or more modified nucleotides which increase the binding affinity of the oligonucleotides to target nucleic acids having a complementary nucleotide base sequence. These modified oligonucleotides hybridize to the target sequence at a faster rate than unmodified oligonucleotides having an identical nucleotide base sequence. Such modified oligonucleotides include oligonucleotides containing at least one 2?-O-methylribofuranosyl moiety joined to a nitrogenous base. Oligonucleotides can be modified in accordance with the present invention to preferentially bind RNA targets. The present invention also concerns methods of using these modified oligonucleotides and kits containing the same.
    Type: Application
    Filed: October 26, 2007
    Publication date: April 17, 2008
    Applicant: GEN-PROBE INCORPORATED
    Inventors: Michael BECKER, Mehrdad MAJLESSI, Steven Brentano
  • Publication number: 20080090247
    Abstract: The present invention concerns oligonucleotides containing one or more modified nucleotides which increase the binding affinity of the oligonucleotides to target nucleic acids having a complementary nucleotide base sequence. These modified oligonucleotides hybridize to the target sequence at a faster rate than unmodified oligonucleotides having an identical nucleotide base sequence. Such modified oligonucleotides include oligonucleotides containing at least one 2?-O-methylribofuranosyl moiety joined to a nitrogenous base. Oligonucleotides can be modified in accordance with the present invention to preferentially bind RNA targets. The present invention also concerns methods of using these modified oligonucleotides and kits containing the same.
    Type: Application
    Filed: October 26, 2007
    Publication date: April 17, 2008
    Applicant: GEN-PROBE INCORPORATED
    Inventors: Michael BECKER, Mehrdad MAJLESSI, Steven Brentano
  • Publication number: 20070299254
    Abstract: The present invention is directed to novel methods of synthesizing multiple copies of a target nucleic acid sequence which are autocatalytic (i.e., able to cycle automatically without the need to modify reaction conditions such as temperature, pH, or ionic strength and using the product of one cycle in the next one). In particular, the present invention discloses a method of nucleic acid amplification which is robust and efficient, while reducing the appearance of side products. The method uses only one primer, the “priming oligonucleotide,” a 3'blocked promoter oligonucleotide and optionally, a means for terminating a primer extension reaction, to amplify RNA or DNA molecules in vitro, while reducing or eliminating the formation of side products. The method of the present invention minimizes or eliminates the emergence of side products, thus providing a high level of specificity.
    Type: Application
    Filed: August 26, 2005
    Publication date: December 27, 2007
    Applicant: GEN-PROBE INCORPORATED
    Inventors: Michael Becker, Wal-Chung Lam, Kristin Livezey, Steven Brentano, Daniel Kolk, Astrid Schroder
  • Publication number: 20070202523
    Abstract: Novel methods of synthesizing multiple copies of a target nucleic acid sequence which are autocatalytic are disclosed (i.e., able to cycle automatically without the need to modify reaction conditions such as temperature, pH, or ionic strength and using the product of one cycle in the next one). In particular, methods of nucleic acid amplification are disclosed which are robust and efficient, while reducing the appearance of side-products. In general, the methods use priming oligonucleotides that target only one sense of a target nucleic acid, a promoter oligonucleotide modified to prevent polymerase extension from its 3?-terminus and, optionally, a means for terminating a primer extension reaction, to amplify RNA or DNA molecules in vitro, while reducing or substantially eliminating the formation of side-pro ducts. The disclosed methods minimizes or substantially eliminate the emergence of side-products, thus providing a high level of specificity.
    Type: Application
    Filed: March 1, 2007
    Publication date: August 30, 2007
    Inventors: Michael BECKER, Wai-Chung Lam, Kristin Livezey, Steven Brentano, Daniel Kolk, Astrid Schroder
  • Publication number: 20060263823
    Abstract: A method of detecting rpoB sequences of Mycobacterium tuberculosis present in a biological sample that includes steps of amplifying the M. tuberculosis rpoB sequence in vitro in a nucleic acid amplification mixture that includes specific disclosed primer sequences, and detecting the amplified sequences by using probes that provide information by their specific hybridization to portions of the amplified nucleic acid is disclosed. Compositions for amplifying and detecting in vitro the rpoB sequences of M. tuberculosis in a sample are disclosed.
    Type: Application
    Filed: July 27, 2006
    Publication date: November 23, 2006
    Applicants: GEN-PROBE INCORPORATED, BIOMERIEUX S.A.
    Inventors: Markus Jucker, Steven Brentano, Francisco Delgado, Philippe Cleuziat
  • Publication number: 20060263822
    Abstract: A method of detecting rpoB sequences of Mycobacterium tuberculosis present in a biological sample that includes steps of amplifying the M. tuberculosis rpoB sequence in vitro in a nucleic acid amplification mixture that includes specific disclosed primer sequences, and detecting the amplified sequences by using probes that provide information by their specific hybridization to portions of the amplified nucleic acid is disclosed. Compositions for amplifying and detecting in vitro the rpoB sequences of M. tuberculosis in a sample are disclosed.
    Type: Application
    Filed: July 28, 2006
    Publication date: November 23, 2006
    Applicants: GEN-PROBE INCORPORATED, BIOMERIEUX S.A.
    Inventors: Markus Jucker, Steven Brentano, Francisco Delgado, Philippe Cleuziat
  • Publication number: 20060194240
    Abstract: Compositions are described for detecting binding of an analyte to a binding partner attached to a nucleic acid hybridization switch probe that includes first and second arm sequences and a support sequence that is at least partially complementary to both arm sequences, allowing the probe under hybridization conditions to form a first conformation in the absence of the analyte and to form a second conformation in the presence of the analyte, and a label associated with the probe that produces a signal that indicates the conformation of the probe. Methods are described for detecting an analyte that forms a specific binding pair with the binding partner attached to the hybridization switch probe, thereby changing the probe from a first to a second conformation that results in a detectable signal that indicates the presence of the analyte in the sample.
    Type: Application
    Filed: February 28, 2006
    Publication date: August 31, 2006
    Applicant: Gen-Probe Incorporated
    Inventors: Lyle Arnold, Lizhong Dai, Steven Brentano, James Russell
  • Publication number: 20060046265
    Abstract: The present invention is directed to novel methods of synthesizing multiple copies of a target nucleic acid sequence which are autocatalytic (i.e., able to cycle automatically without the need to modify reaction conditions such as temperature, pH, or ionic strength and using the product of one cycle in the next one). In particular, the present invention discloses a method of nucleic acid amplification which is robust and efficient, while reducing the appearance of side-products. The method uses only one primer, the “priming oligonucleotide,” a promoter oligonucleotide modified to prevent polymerase extension from its 3?-terminus and, optionally, a means for terminating a primer extension reaction, to amplify RNA or DNA molecules in vitro, while reducing or substantially eliminating the formation of side-products. The method of the present invention minimizes or substantially eliminates the emergence of side-products, thus providing a high level of specificity.
    Type: Application
    Filed: August 26, 2005
    Publication date: March 2, 2006
    Applicant: Gen-Probe Incorporated
    Inventors: Michael Becker, Wai-Chung Lam, Kristin Livezey, Steven Brentano, Daniel Kolk, Astrid Schroder
  • Publication number: 20060014142
    Abstract: Nucleic acid oligomeric sequences and in vitro nucleic acid amplification and detection methods for detecting the presence of HAV RNA sequences in samples are disclosed. Kits comprising nucleic acid oligomers for amplifying and detecting HAV nucleic acid sequences are disclosed.
    Type: Application
    Filed: July 13, 2005
    Publication date: January 19, 2006
    Applicant: Gen-Probe Incorporated
    Inventors: James Carlson, Steven Brentano
  • Publication number: 20050260562
    Abstract: The present invention describes oligonucleotides targeted to HPV Type 16 and/or Type 18 nucleic acid sequences which are particularly useful to aid in detecting HPV type 16 and or 18. The oligonucleotides can aid in detecting HPV Type 16 and/or Type 18 in different ways such as by acting as hybridization assay probes, helper probes, and/or amplification primers.
    Type: Application
    Filed: June 26, 2003
    Publication date: November 24, 2005
    Inventors: Patricia Gordon, Nick Carter, Steven Brentano, Philip Hammond
  • Publication number: 20050227227
    Abstract: Sequences of nucleic acid oligonucleotides for amplifying different portions of gag and pol genes of HIV-1 and for detecting such amplified nucleic acid sequences are disclosed. Methods of amplifying and detecting HIV-1 nucleic acid in a biological sample using the amplification oligonucleotides specific for gag and pol target sequences are disclosed.
    Type: Application
    Filed: June 3, 2005
    Publication date: October 13, 2005
    Inventors: Yeasing Yang, Steven Brentano, Odile Babola, Nathalie Tran, Guy Vernet
  • Publication number: 20050106610
    Abstract: The present invention concerns oligonucleotides containing one or more modified nucleotides which increase the binding affinity of the oligonucleotides to target nucleic acids having a complementary nucleotide base sequence. These modified oligonucleotides hybridize to the target sequence at a faster rate than unmodified oligonucleotides having an identical nucleotide base sequence. Such modified oligonucleotides include oligonucleotides containing at least one 2?-O-methylribofuranosyl moiety joined to a nitrogenous base. Oligonucleotides can be modified in accordance with the present invention to preferentially bind RNA targets. The present invention also concerns methods of using these modified oligonucleotides and kits containing the same.
    Type: Application
    Filed: October 26, 2004
    Publication date: May 19, 2005
    Inventors: Michael Becker, Mehrdad Majlessi, Steven Brentano
  • Publication number: 20050100915
    Abstract: Oligonucleotides used to prime in vitro nucleic acid amplification of 16S rRNA sequences or DNA encoding 16S rRNA sequences for many species within the genus Mycobacterium are disclosed. Kits including such oligonucleotides are disclosed. Methods of detecting Mycobacterium species using the oligonucleotides in in vitro nucleic acid amplification are disclosed.
    Type: Application
    Filed: September 18, 2003
    Publication date: May 12, 2005
    Inventors: Steven Brentano, Markus Jucker, Francisco Delgado, Philippe Cleuziat, Marc Rodrigue