Abstract: The present invention relates to the use of a fatty acid ester as a slip additive in the production of molded polyethylene terephthalate articles, to a thermoplastic molding composition comprising a polyethylene terephthalate and a fatty acid ester selected to be effective for reducing the co-efficient of friction of molded articles formed from the composition, to a molded polyethylene terephthalate article comprising a fatty acid ester selected to be effective in reducing the co-efficient of friction of the molded article, and to a process for producing a molded thermoplastic article comprising providing a thermoplastic molding composition comprising polyethylene terephthalate, admixing with the thermoplastic molding composition at least one fatty acid ester selected to be effective in reducing the co-efficient of friction of the molded article, heating the composition and molding the hot composition so as to form a molded article.

Abstract: This disclosure provides a new class of compounds referred to as “reversed chloroquines” (RCQs), which are highly effective against CQR and CQS malaria parasites. RCQs are hybrid molecules, which include an antimalarial quinoline analog (such as chloroquine) moiety and a CQR reversal moiety. Exemplary RCQ chemical structures are provided. Also provided are pharmaceutical compositions including the disclosed RCQ compounds, and methods of using such compounds and compositions for the treatment of malaria and inhibition of CQR or CQS Plasmodium sp. (such as P. falciparum).

Abstract: A closure 40 for a container body includes a liner 46 which incorporates a hydrogen generating device comprising a hydride which generates hydrogen on contact with moisture. The liner may be an interference fit within the body 42. The liner 46 and other liners described may include control means for controlling passage of moisture to the hydrogen generating means and/or sealing means for sealing the closure to a container. In use, with the closure secured to a container, water vapour passes into liner 46 and contacts the hydride which generates hydrogen. A reaction between hydrogen and oxygen which has passed into the container takes place, catalysed by a catalyst, and water is produced. Thus, oxygen is scavenged.

Abstract: A closure (40) includes a body (42) with a screw threaded portion (44) for engaging the closure with a container, for example a bottle. Inwards of portion (44) is a liner (46) comprising a hydrogen generating device, wherein the liner includes one layer (48) which incorporates a hydride dispersed in a polymeric matrix and, on opposite sides of layer (48) are arranged PET layers (50, 52). Layer (50) is arranged to act as a control layer to control the rate of passage of water vapour from the beverage in the container to the hydride containing layer (48) and thereby control generation of hydrogen by the hydrogen generating device. In use, water vapour passes through layer (50) and contacts the hydride associated with layer (48) which results in production of molecular hydrogen which combines with oxygen which may have entered a container with which the closure (40) is associated.

Abstract: This disclosure provides a new class of compounds referred to as “reversed chloroquines” (RCQs), which are highly effective against CQR and CQS malaria parasites. RCQs are hybrid molecules, which include an antimalarial quinoline analog (such as chloroquine) moiety and a CQR reversal moiety. Exemplary RCQ chemical structures are provided. Also provided are pharmaceutical compositions including the disclosed RCQ compounds, and methods of using such compounds and compositions for the treatment of malaria and inhibition of CQR or CQS Plasmodium sp. (such as P. falciparum).

Abstract: This disclosure provides a new class of compounds referred to as “reversed chloroquines” (RCQs), which are highly effective against CQR and CQS malaria parasites. RCQs are hybrid molecules, which include an antimalarial quinoline analog (such as chloroquine) moiety and a CQR reversal moiety. Exemplary RCQ chemical structures are provided. Also provided are pharmaceutical compositions including the disclosed RCQ compounds, and methods of using such compounds and compositions for the treatment of malaria and inhibition of CQR or CQS Plasmodium sp. (such as P. falciparum).

Abstract: The present invention relates to the use of a fatty acid ester as a slip additive in the production of moulded polyethylene terephthalate articles, to a thermoplastic moulding composition comprising a polyethylene terephthalate and a fatty acid ester selected to be effective for reducing the co-efficient of friction of moulded articles formed from the composition, to a moulded polyethylene terephthalate article comprising a fatty acid ester selected to be effective in reducing the co-efficient of friction of the moulded article, and to a process for producing a moulded thermoplastic article comprising providing a thermoplastic moulding composition comprising polyethylene terephthalate, admixing with the thermoplastic moulding composition at least one fatty acid ester selected to be effective in reducing the co-efficient of friction of the moulded article, heating the composition and moulding the hot composition so as to form a moulded article.

Abstract: A container (22) includes a shell (24) made from a polymer, for example PET, and incorporating a catalyst, for example a palladium catalyst. A closure (40) incorporates a plug which includes a source of hydrogen, for example a hydride. In use, with container (22) including a beverage and closure (40) in position, the headspace in the container will be saturated with water vapor. This vapor contacts the hydride associated with plug (42) and as a result the hydride produces molecular hydrogen which migrates into the polymer matrix of shell (24) and combines with oxygen which may have entered the container through its permeable walls. A reaction between the hydrogen and oxygen takes place, catalysed by the catalyst, and water is produced. Thus, oxygen which may ingress the container is scavenged and the contents of the container are protected from oxidation.

Abstract: This disclosure provides a new class of compounds referred to as “reversed chloroquines” (RCQs), which are highly effective against CQR and CQS malaria parasites. RCQs are hybrid molecules, which include an antimalarial quinoline analog (such as chloroquine) moiety and a CQR reversal moiety. Exemplary RCQ chemical structures are provided. Also provided are pharmaceutical compositions including the disclosed RCQ compounds, and methods of using such compounds and compositions for the treatment of malaria and inhibition of CQR or CQS Plasmodium sp. (such as P. falciparum).

Abstract: A method for fabricating a component using a tool includes determining an actual property of a region of the component, comparing the actual property of the region of the component with an expected property of the region to determine a difference between the actual property and the expected property, and updating a path of the tool that is electronically stored in a memory and executable by a processor for fabricating the component based on the difference between the actual property and the expected property of the region.

Abstract: A method for arranging a life insurance transaction while managing risk exposure associated with the transaction is disclosed. In one embodiment, the method includes coordinating the initiation of an insurance policy that relates to the life of a person. Execution of a loan on behalf of an owner of the policy for the payment of premiums due on the policy is also coordinated with a lending entity. The posting of collateral for the loan by a third party is coordinated, thereby removing risk exposure from the lending entity, the policy owner, and/or the insured.

Abstract: A directional speaker system includes an enclosure having an inner surface, an outer surface, an open end, and a closed end, a speaker driver directed toward the open end and mounted near the closed end of the enclosure, an in-line phase plug mounted in front of the speaker driver for manipulating the wavefront of sound waves produced by the speaker driver, and a preferably frustoconical shaped wave guide provided between the speaker driver and the open end of the speaker enclosure. A preferably annular space is provided between the enclosure and the wave guide and a plurality of openings are provided between the enclosure at the open end of the enclosure. Out-of-phase sound waves produced by the speaker driver travel into the space and exit the speaker system through the openings.

Abstract: A directional speaker system includes an enclosure having an inner surface, an outer surface, an open end, and a closed end, a speaker driver directed toward the open end and mounted near the closed end of the enclosure, an in-line phase plug mounted in front of the speaker driver for manipulating the wavefront of sound waves produced by the speaker driver, and a preferably frustoconical shaped wave guide provided between the speaker driver and the open end of the speaker enclosure. The in-line phase plug preferably has a plurality of channels. The open end of the enclosure is preferably provided with an acoustically absorbent material around its inner perimeter. A second acoustically absorbent material is provided between the speaker driver, the in-line phase plug, and the wave guide, and the speaker enclosure. The in-line phase plug, wave guide phase plug and baffle plate operate to flatten the wavefront.