Abstract: Methods for determining the validity or accuracy of a clinical test result are provided. The methods entail obtaining patient analyte concentration data for two or more analytes with a concentration relationship; calculating a likelihood distribution for the concentration relationship between the two or more analytes; obtaining a clinical test result comprising measured concentration values for the two or more analytes; and determining the validity or accuracy of the clinical test result based on whether the clinical test result falls within the boundaries of the likelihood distribution. Analyte pairs that can be analyzed by the methods of the invention include albumin/calcium, sodium/chloride, BUN/creatinine, AST/ALT, total protein/albumin, potassium/total CO2, calcium/phosphorus, calcium/magnesium, potassium/creatinine, magnesium/potassium, Anion gap/potassium, sodium/potassium, chloride/potassium, magnesium/phosphate, ALT/GGT, ALT/ALP, CK/LDH and chloride/total CO2.