Abstract: Dural repair devices that are configured to effectively and reliably repair the damage of a dural tear due to incidental durotomies are provided, along with methods of use. The devices and methods enhance the ability of a surgeon to repair a patent's dura mater, or dura, during surgery of the central nervous system. The dural repair device has a multi-layer structure configured to exert a pressure or tamponade effect to compress a patient's dura to its state prior to the spinal surgery. Thus, the dural repair devices and methods of use may reduce the patient's risk morbidity, further surgery, spinal headaches, or other injuries and discomforts.

Abstract: Systems and methods for preventing the seeding of cancerous cells during morcellation of a tissue specimen inside a patient's body and removal of the tissue specimen from inside the patient through a minimally-invasive body opening to outside the patient are provided. One system includes a cut-resistant tissue guard removably insertable into a containment bag. The tissue specimen is isolated and contained within the containment bag and the guard is configured to protect the containment bag and surrounding tissue from incidental contact with sharp instrumentation used during morcellation and extraction of the tissue specimen. The guard is adjustable for easy insertion and removal and configured to securely anchor to the body opening. Protection-focused and containment-based systems for tissue removal are provided that enable minimally invasive procedures to be performed safely and efficiently.

Abstract: An electronic device, such as a watch, has a crown assembly having a shaft and a user-rotatable crown. The user-rotatable crown may include a conductive cap that is mechanically and electrically coupled to the shaft and functions as an electrode. The conductive cap may be coupled to the shaft using solder or another conductive attachment mechanism. The shaft may electrically couple the conductive cap to a processing unit of the electronic device. One or more additional electrodes may be positioned on the exterior surface of the electronic device. The conductive cap is operable to be contacted by a finger of a user of the electronic device while another electrode is positioned against skin of the user. The processing unit of the electronic device is operable to determine a biological parameter, such as an electrocardiogram, of the user based on voltages at the electrodes.

Abstract: An irrigated ablation electrode assembly comprises a distal member, a first manifold, and a second manifold. The distal member includes an outer surface; an inner surface; and at least one radially extending passageway that extends from the inner surface of the distal member to the outer surface of the distal member. The first manifold includes an outer surface, an inner cavity, and at least one radially extending passageway that extends from the inner cavity to the outer surface of the first manifold. The second manifold includes an outer surface, an inner surface, and at least one radially extending passageway that extends from the inner surface of the second manifold to the outer surface of the second manifold. Other irrigated ablation electrode assemblies are also presented.

Abstract: The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifin, and compositions comprising them. The present disclosure also provides methods for treating hormone-dependent breast and hormone-dependent reproductive tract disorders.

Abstract: A ride system includes at least one ride vehicle. The at least one ride vehicle is configured to receive a ride passenger. The ride system includes electronic goggles configured to be worn by the ride passenger. The electronic goggles include a camera and a display. The ride system includes a computer graphics generation system communicatively coupled to the electronic goggles, and configured to generate streaming media of a real world environment based on image data captured via the camera of the electronic goggles, generate one or more virtual augmentations superimposed on the streaming media of the real world environment, and to transmit the streaming media of the real world environment along with the one or more superimposed virtual augmentations to be displayed on the display of the electronic goggles.

Abstract: A programmable lighting system includes a plurality of color channels configured to generate light of different colors, and a light driver configured to drive the plurality of color channels according to a dimmer setting and a correlated color temperature (CCT) setting, and to maintain a constant maximum lumen output across a range of CCT values based on a dim-stop limit.

Abstract: A system that calibrates timing relationships between signals involved in performing write operations is described. This system includes a memory controller which is coupled to a set of memory chips, wherein each memory chip includes a phase detector configured to calibrate a phase relationship between a data-strobe signal and a clock signal received at the memory chip from the memory controller during a write operation. Furthermore, the memory controller is configured to perform one or more write-read-validate operations to calibrate a clock-cycle relationship between the data-strobe signal and the clock signal, wherein the write-read-validate operations involve varying a delay on the data-strobe signal relative to the clock signal by a multiple of a clock period.

Abstract: A turbine engine with a compressor section, a combustion section, and a turbine section in serial flow arrangement along an engine centerline. The combustion section includes a primary combustor liner including an inner liner and an outer liner. A dome wall and a primary dome inlet are located in the dome wall. The outer liner defines at least one opening downstream from the primary dome inlet. A primary combustion chamber and a set of secondary combustors are fluidly coupled to the primary combustion chamber at the at least one opening.

Abstract: A controller for one or more pumps in a central plant is configured to obtain first values of flow rate of a fluid provided by the one or more pumps to a building or campus and corresponding first values of a pressure differential across the building or campus during a first time period, generate a system curve for the building or campus that defines a relationship between the flow rate and the pressure differential using the first values of flow rate and pressure differential during the first time period, predict a second value of the pressure differential across the building or campus during a second time period using the system curve and a second value of the flow rate during the second time period, and operate the one or more pumps to achieve the second value of the pressure differential across the building or campus during the second time period.

Abstract: A tester apparatus is provided. Slot assemblies are removably mounted to a frame. Each slot assembly allows for individual heating and temperature control of a respective cartridge that is inserted into the slot assembly. A closed loop air path is defined by the frame and a heater and cooler are located in the closed loop air path to cool or heat the cartridge with air. Individual cartridges can be inserted or be removed while other cartridges are in various stages of being tested or in various stages of temperature ramps.

Abstract: A mastless vertical axis wind turbine that comprises a plurality of sails that rotate about a vertical axis under the influence of wind. A platform is connected to and in tension with the plurality of sails at one or more points about the bottom of the plurality of the sails. Also, an external frame is connected to and in tension with the plurality of sails at one or more points about the top of the plurality of the sails. The external frame itself comprises a plurality of legs that converge above the plurality of sails at a central point about the vertical axis of rotation and extend beyond the path swept by the plurality of sails. A coupling mechanism connects one or more of the plurality of legs to the plurality of sails and allows the sails to rotate about the vertical axis of rotation while the legs remain stationary.

Abstract: A controller periodically (based on, for example, clock time or number of intervening activate commands) issues mitigation operation commands. For each (or some) mitigation operation command issued, the controller probabilistically determines whether to increase or decrease the configured number of rows in the vicinity of the suspected aggressor row that are to be refreshed by the next mitigation operation command it issues.

Abstract: Methods for treating liver immune dysfunction in a subject are provided. The liver immune dysfunction may be induced by at least one tumor resulting from metastasis in the liver or at least one primary liver cancer. An exemplary method comprises administering to the subject a toll-like receptor 9 (TLR9) agonist, for example, a TLR 9 agonist having the structure: 5?-TCG AAC GTT CGA ACG TTC GAA CGT TCG AAT-3. The TLR9 agonist is administered to the liver, for example, the TLR9 agonist may be administered to the liver using a locoregional therapy through the vasculature.

Abstract: A vehicle hood assembly can include a vehicle body structure and a hood moveable with respect to the vehicle body structure from a closed state to an opened state. A first linkage can connect the hood to the vehicle body structure and include a first linkage aperture extending therethrough. A second linkage can connect the hood to the vehicle body structure and include a second linkage aperture extending therethrough. A central axis of the first linkage aperture can be coaxial with a central axis of the second linkage aperture if the hood is in the opened state. A key structure can be provided and configured to simultaneously fit into both the second linkage aperture and the first linkage aperture if the hood is in the opened state.

Abstract: An electronic device, such as a watch, has an input mechanism, such as a crown, that may receive translational inputs, rotational inputs, and/or touch inputs. Inputs received at the crown may result in changes in operation of the electronic device and/or outputs, such as graphical outputs, provided by the electronic device. In various embodiments, the crown includes a retainer that couples an outer crown body to an inner crown body and secures an isolator between the outer crown body and the inner crown body. The embodiments of the crown described herein provide a simple and robust input mechanism for receiving rotational, translational, and touch inputs as described above, while simplifying part alignment, ensuring consistent rotation, and allowing for efficient manufacturing.

Abstract: This document discloses a novel class of compounds for inhibiting bacterial growth and treating bacterial infection. The compounds target a key step of the futalosine pathway and therefore are effective for the selective inhibition of certain bacterial species and genera with reduced side effect in comparison with conventional antibiotics.

Abstract: A gluten-free pasta product that survives retort may be formed by preparing a dough mixture with gluten-free flour and water. The dough can be extruded at a temperature and with an amount of mechanical energy effective to form an extruded pasta product having a bi-continuous matrix of protein and starch. The extruded pasta product can be incorporated into a closed retort container and subsequently retorted. The resulting retorted food product may contain gluten-free pasta that has the structural integrity and textual firmness consistent with that exhibited by traditional wheat pasta after having undergone retort despite the absence of binding gluten molecules.

Abstract: A tester apparatus is described. Various components contribute to the functionality of the tester apparatus, including an insertion and removal apparatus, thermal posts, independent gimbaling, the inclusion of a photo detector, a combination of thermal control methods, a detect circuitry in a socket lid, through posts with stand-offs, and a voltage retargeting.

Abstract: A tester apparatus is described. Various components contribute to the functionality of the tester apparatus, including an insertion and removal apparatus, thermal posts, independent gimbaling, the inclusion of a photo detector, a combination of thermal control methods, a detect circuitry in a socket lid, through posts with stand-offs, and a voltage retargeting.