Abstract: The subject matter disclosed herein is generally directed to epitopes that specifically bind to subject specific HLA class I molecules in MCC. The epitope identified is specific for MCC and is encoded for in the Merkel Cell Polyomavirus (MCPyV) large T antigen (MCPyV LT).

Abstract: Methods disclosed herein concern cancer proteogenomics, which integrates genomics, transcriptomics and mass spectrometry (MS)-based proteomics to gain insights into cancer biology and treatment efficacy. To promote clinical utility of embodiments herein, proteogenomics approaches were developed for frozen core needle biopsies using tissue-sparing specimen processing with or without a microscaled proteomics workflow.

Abstract: Immunogenic compositions comprising one or more polypeptides, wherein the one or more polypeptides: is capable of binding to Major Histocompatibility Complex (MHC) class I, and is derived from one or more proteins of SARS-CoV-2. Also provided include methods of treating and preventing diseases using the immunogenic compositions.

Abstract: Disclosed herein are polypeptides and compositions comprising one or more neoantigens, methods of identifying neoantigens, and methods for preparing a neoantigen for an immunogenic pharmaceutical composition. The neoantigen can be specific to a subject that has a cancer, disease, or other disorder.

Abstract: Adaptive immune responses rely on the ability of cytotoxic T cells to identify and eliminate cells displaying disease-specific antigens on human leukocyte antigen (HLA) class I molecules. Investigations into antigen processing and display have immense implications in human health, disease and therapy. To extend understanding of the rules governing antigen processing and presentation, immunopurified peptides from B cells, each expressing a single HLA class I allele, were profiled. A resource dataset containing thousands of peptides bound to distinct class I HLA-A, -B, and -C alleles was generated by implementing a novel allele-specific database search strategy. Applicants discovered new binding motifs, established the role of gene expression in peptide presentation and improved prediction of HLA-peptide binding by using these data to train machine-learning models. These streamlined experimental and analytic workflows enable direct identification and analysis of endogenously processed and presented antigens.

Abstract: The present disclosure provides for compositions and methods of treating cancer. In some embodiments, PTPN11 is targeted with and anti-PTPN11 drug, such as a Shp2 inhibitor (e.g., SHP099). In some embodiments, other upregulated, hyperphosphorylated, or hyperacetylated target proteins are inhibited or targeted.

Abstract: The combined dual bevel miter and radial arm saw device provides the advantages of both a radial arm saw and a miter saw. The device thereby provides for cross cuts, rip cuts and angle cuts, all simultaneously if desired.

Abstract: A method and system of selecting assets for display in an interactive media guidance application includes receiving a user input indicating interest in a media item; generating a list of media assets related to the media item, selecting, based on priority rules, a subset of the media assets to display in an interactive media guidance application, and displaying an identifier for each of the subset of media assets in the interactive media guidance application screen. The priority rules may assign a first priority to one type of media asset and a second priority to a second type of media asset, and may be based on: whether the media asset has been viewed, and a respective time associated with the media asset.

Abstract: A method and system of selecting assets for display in an interactive media guidance application includes receiving a user input indicating interest in a media item; generating a list of media assets related to the media item, selecting, based on priority rules, a subset of the media assets to display in an interactive media guidance application, and displaying an identifier for each of the subset of media assets in the interactive media guidance application screen. The priority rules may assign a first priority to one type of media asset and a second priority to a second type of media asset, and may be based on: whether the media asset has been viewed, and a respective time associated with the media asset.

Abstract: A method and system of selecting assets for display in an interactive media guidance application includes receiving a user input indicating interest in a media item; generating a list of media assets related to the media item, selecting, based on priority rules, a subset of the media assets to display in an interactive media guidance application, and displaying an identifier for each of the subset of media assets in the interactive media guidance application screen. The priority rules may assign a first priority to one type of media asset and a second priority to a second type of media asset, and may be based on: whether the media asset has been viewed, and a respective time associated with the media asset.

Abstract: A data services handler comprises an interface between a data store and applications that supply and consume data, and a real time information director (RTID) that transforms data under direction of polymorphic metadata that defines a security model and data integrity rules for application to the data.

Abstract: An information handling method includes constructing aggregates for a case set, computing aggregates from detailed in-memory data that is dynamically cached, and iteratively mining data during an entity transaction to define new aggregates and refine existing aggregates based on entity responses. The aggregates are defined and refined using a wizard.

Abstract: An information handling method comprises a recommender with an aggregation engine capable of computing aggregates in from in-memory data that is dynamically cached during a transaction with an entity.