Abstract: The present disclosure relates to cannula systems for delivery of a therapeutic agent to parenchymal tissue of a target subject. In certain embodiments, the cannula system is for delivery of a therapeutic agent to parenchymal tissue in the spine of a target subject. In certain embodiments, the cannula system includes a cannula positioning guide (CPG) useful in the delivery of a therapeutic agent to a localized target tissue of a subject. The guide may be used in a surgical suite or during a surgical procedure.

Abstract: A wheel hub assembly apparatus comprising a housing configured for operative fitment to a wheel hub assembly. Also included is at least one air pressure sensor having a fluid connection for in situ fitment to tire valve and configured to selectively sense a pressure of a tire mounted on the wheel hub assembly, a temperature detector configured to detect an ambient temperature within the wheel hub assembly, a display configured to provide external display of information, and a controller arranged in signal communication with the pressure sensor, temperature detector and display, the controller configured to receive sensed pressure and/or detected temperature and to display same via the display.

Abstract: Method and systems of registering participants for an event at an event site are disclosed. Identification data specific to a participant encoded on a first token object is read with a mobile computing device. A query is generated from the mobile computing device to a remote event registration system for prior registration data based upon at least a subset of the received identification data. The prior registration data is received on the mobile computing device. A first subset of the prior registration data is transmitted to a local event registration system, and a payment success indicator is received upon successful payment processing. Registrant identification data is generated by the local event registration system in response to recording the first subset of the prior registration data and the payment success indicator.

Abstract: Method and systems of registering participants for an event at an event site are disclosed. Identification data specific to a participant encoded on a first token object is read with a mobile computing device. A query is generated from the mobile computing device to a remote event registration system for prior registration data based upon at least a subset of the received identification data. The prior registration data is received on the mobile computing device. A first subset of the prior registration data is transmitted to a local event registration system, and a payment success indicator is received upon successful payment processing. Registrant identification data is generated by the local event registration system in response to recording the first subset of the prior registration data and the payment success indicator.

Abstract: A slat for use in a covering for an architectural opening is made from a base material of binder and matrix fibers which are formed into a nonwoven material by melting at least a portion of the binder fibers to thermally bond the binder and matrix fibers. A coating of resin is then applied to the thermally bonded base before the composite material is passed through a forming apparatus where the material is heated over a convex support having the desired curvature for the slat and subsequently cooled.

Abstract: A method and apparatus for forming a transversely curved or formed strip of material which can be cut to length for use in a fabric for coverings for architectural opening includes a supply role of a flexible fabric strip material that is sequentially passed through a heating chamber with an elongated upwardly convex extrusion across which the strip material is drawn and a cooling station before being wrapped on a take-up drum. The apparatus includes driven rollers about which the strip material passes and the strip material is exposed to tension detectors and controlled temperatures such that the strip material formed in the apparatus is uniform along its length.

Abstract: The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

Abstract: A system and method are provided to intelligently limit the frequency at which automated or semi-automated trading tools move or re-price orders in an exchange order book. A tolerance may be input that limits when one or more orders in the exchange order book are moved from one price to another. The system and method assist in reducing the number of orders that are entered into the system which can lead to reduced exchange transaction fees, lost queue position, and reduce network bandwidth consumption.

Abstract: Thee present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA via replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or creating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

Abstract: The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

Abstract: A system and method are provided to intelligently limit the frequency at which automated or semi-automated trading tools move or re-price orders in an exchange order book. A tolerance may be input that limits when one or more orders in the exchange order book are moved from one price to another. The system and method assist in reducing the number of orders that are entered into the system which can lead to reduced exchange transaction fees, lost queue position, and reduce network bandwidth consumption.

Abstract: A system for displaying performance test information for software. The system includes a graphical user interface that displays information in a format to allow ready identification of performance problems and their causes. The interface includes a timeline view depicting activity levels during the execution of a program under test. Events during a sub-range of times during the program execution may be displayed with information revealing interactions of threads making up the program. Additional information may be displayed in a further display fields, including textual information. Much of the displayed information is represented graphically, allowing a performance engineer to quickly identify areas of the program to investigate further.

Abstract: In one aspect, a method and apparatus for formatting code coverage data generated by performing one or more code coverage tests on a program module derived from computer code is provided, including organizing the code coverage data in a hierarchy having a plurality of tables, each of the plurality of tables configured to store information at one of successive levels of refinement, and storing, in each of the plurality of tables, code coverage information indicative of code coverage at a respective one of the successive levels of refinement.

Abstract: Systems and methods are provided that determine the actual amount of time a processor consumes in executing a code portion. The actual execution time of a code portion may be accurately determined by taking into consideration context switches and/or overhead time corresponding to the code portion. Determining the actual execution time of a code portion may include recording context switches and time values that occur during the execution of the code portion. This information along with overhead measurements may be used to generate the actual execution time of a code portion, as will be described in more detail below. For example, the switched-out intervals resulting from the context switches and the overhead time associated with the time measurements may be subtracted from the elapsed time to produce the actual execution time of a code portion.

Abstract: The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

Abstract: A versatile system which includes a display unit by which a plurality of image works selected from photographs, paintings, newspaper articles, pictures, images, prints, designs, sports memorabilia, certificates, awards, and diplomas may be viewed simultaneously or individually, as selected by the viewer. A display unit stores a plurality of image works for selective viewing by an observer by virtue of each image works being mounted on a slidable carrier, which may be slid within a framework to enable or disable viewing of image works which may be disposed behind a given slidable carrier.