Patents by Inventor Steven Chao-Huan Chang

Steven Chao-Huan Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cartilage-derived morphogenetic proteins
    Patent number: 7220558
    Abstract: Nucleotide and amino acid sequences of cartilage-derived morphogenetic proteins (CDMP-1 and CDMP-2) from human and bovine cartilage extracts. These proteins exhibit chondrogenic activity and can be used to repair cartilage defects in a mammal.
    Type: Grant
    Filed: March 3, 2003
    Date of Patent: May 22, 2007
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Frank P. Luyten, Malcolm Moos, Jr., Steven Chao-Huan Chang
  • DNA molecules encoding cartilage-derived morphogenetic proteins
    Patent number: 7148036
    Abstract: The present invention is a purified cartilage extract that stimulates local cartilage formation when combined with a matrix and implanted into a mammal. This extract can conveniently be produced by a method which includes the steps of: obtaining cartilage tissue; homogenizing the cartilage tissue in the presence of chaotropic agents under conditions that permit separation of proteins from proteoglycans; separating the proteins from the proteoglycans and then obtaining the proteins. The step for separating the proteins from the proteoglycans can be carried out using a sepharose column. The extract can also be obtained by additionally including the steps of separating the proteins on a molecular sieve and then collecting the proteins having molecular weights in the 30 kDa to 60 kDa size range. Articular cartilage or epiphyseal cartilage can be used in the preparation of this purified extract.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: December 12, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Frank P. Luyten, Malcolm Moos, Jr., Steven Chao-Huan Chang
  • Cartilage-Derived morphogenetic proteins
    Publication number: 20030185898
    Abstract: the present invention is a purified cartilage extract that stimulates local cartilage formation when combined with a matrix and implanted into a mammal. This extract can conveniently be produced by a method which includes the steps of: obtaining cartilage tissue; homogenizing the cartilage tissue in the presence of chaotropic agents under conditions that permit separation of proteins from proteoglycans; separating the proteins from the proteoglycans and then obtaining the proteins. The step for separating the proteins from the proteoglycans can be carried out using a sepharose column. The extract can also be obtained by additionally including the steps of separating the proteins on a molecular sieve and then collecting the proteins having molecular weights in the 30 kDa to 60 kDa size range. Articular cartilage or epiphyseal cartilage can be used in the preparation of this purified extract.
    Type: Application
    Filed: May 19, 2000
    Publication date: October 2, 2003
    Inventors: Frank P. Luyten, Malcolm Moos, Steven Chao-Huan Chang
  • Cartilage-derived morphogenetic proteins
    Publication number: 20030176683
    Abstract: Nucleotide and amino acid sequences of cartilage-derived morphogenetic proteins (CDMP-1 and CDMP-2) from human and bovine cartilage extracts. These proteins exhibit chondrogenic activity and can be used to repair cartilage defects in a mammal.
    Type: Application
    Filed: March 3, 2003
    Publication date: September 18, 2003
    Inventors: Frank P. Luyten, Malcolm Moos, Steven Chao-Huan Chang
  • DNA molecules encoding cartilage-derived morphogenetic proteins
    Publication number: 20010037017
    Abstract: Nucleotide and amino acid sequences of cartilage-derived morphogenetic proteins (CDMP-1 and CDMP-2) from human and bovine cartilage extracts. These proteins exhibit chondrogenic activity and can be used to repair cartilage defects in a mammal.
    Type: Application
    Filed: December 13, 2000
    Publication date: November 1, 2001
    Inventors: Frank P. Luyten, Malcolm Moos, Steven Chao-Huan Chang
  • DNA molecules encoding cartilage-derived morphogenetic proteins
    Publication number: 20010011131
    Abstract: Nucleotide and amino acid sequences of cartilage-derived morphogenetic proteins (CDMP-1 and CDMP-2) from human and bovine cartilage extracts. These proteins exhibit chondrogenic activity and can be used to repair cartilage defects in a mammal.
    Type: Application
    Filed: December 5, 2000
    Publication date: August 2, 2001
    Inventors: Frank P. Luyten, Malcolm Moos, Steven Chao-Huan Chang