Abstract: Disclosed are methods of isolating paired T cell receptor (TCR) alpha and beta chain sequences, or an antigen-binding portion thereof. Also disclosed are methods of automatically identifying the TCR alpha and beta chain V segment sequences and CDR3 sequences of a TCR having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation. Methods of preparing a population of cells that express paired TCR alpha and beta chain sequences, or an antigen-binding portion thereof, are also disclosed. Isolated pairs of TCR alpha and beta chain sequences and isolated populations of cells prepared by the methods are also disclosed.

Abstract: The disclosure herein describes systems and methods for object data storage. In some examples, the method includes generating a profile for an object in a directory, the profile including a first feature vector corresponding to the object and a global unique identifier (GUID) corresponding to the first feature vector in the profile; generating a search scope, the search scope including at least the GUID corresponding to the profile; generating a second feature vector from a live image scan; matching the generated second feature vector from the live image scan to the first feature vector using the generated search scope; identifying the GUID corresponding to the first feature vector that matches the second feature vector; and outputting information corresponding to the object of the profile identified by the GUID corresponding to the first feature vector.

Abstract: Disclosed herein is a flexible sensing interface, comprising: a sensor, comprising: a core; an inner electrode in the form of a conductive material in contact with the core; an inner dielectric material substantially encasing the inner electrode; an outer electrode in the form of a conductive material in contact with the inner dielectric material and in electrical communication with the inner electrode; and an outer dielectric material substantially encasing the outer electrode; wherein the inner dielectric material and the outer dielectric material comprise an elastic material. Also disclosed herein are systems and methods for making and using the same.

Abstract: One variation of a method includes: detecting a first location of a user carrying a mobile pack proximal a first scan zone; accessing a first sequence of images representing trees in the first scan zone; characterizing a first coverage density of the first scan zone based on visual features detected in the first sequence of images; in response to the first coverage density exceeding a threshold coverage density, alerting the user of scan completion; detecting a second location of the user proximal a second scan zone; accessing a second sequence of images representing trees in the second scan zone; characterizing a second coverage density of the second scan zone based on visual features detected in the second sequence of images; and, in response to the second coverage density falling below the threshold coverage density, prompting the user to increase a traversal speed for a third scan zone.

Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

Abstract: In an example, a semiconductor device includes a first steering diode and a second steering diode at a top side of a region of semiconductor material, a first Zener diode buried within the region of semiconductor material, and a second Zener diode at a bottom side of the region of semiconductor material. The semiconductor device is configured as a bi-directional electrostatic discharge (ESD) structure. The first Zener diode and the first steering diodes are configured to respond to a positive ESD pulse, and the second Zener diode and the second steering diode are configured to respond to a negative ESD pulse. The steering diodes are configured to have low capacitances and the Zener diodes are configured to provide enhanced ESD protection. Other related examples and methods are disclosed herein.

Abstract: Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated human p53. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

Abstract: A method includes machining a raw surface of a metal component to remove first native oxide from a metal base of the metal component to generate an as-machined surface of the metal component. A second native oxide is formed on the metal base of the as-machined surface of the metal component subsequent to the machining. The method further includes, subsequent to the machining, performing operations to generate a finished surface of the metal component. The operations include a surface machining of the as-machined surface of the metal component to remove the second native oxide.

Abstract: Disclosed is an impact modified resin comprises a matrix polymer resin and an impact modifier. The impact modifier comprises particles of a crosslinked polyolefin elastomer having one or more (meth)acrylic monomers grafted to the crosslinked polyolefin elastomer particles. The matrix polymer resin is a styrenic polymer.

Abstract: A method for delivering a plurality of packages is described. The method includes obtaining, via a processor, information associated with a delivery plan of the plurality of packages from at least one memory. Based on the information, the method includes determining, via the processor, a current location, and a destination location of a target container. In response to the determination, the method includes determining, via the processor, a movement plan to move the target container to the destination location. Based on the movement plan, the method includes activating, via the processor, a first set of motorized tiles to move the target container to the destination location. The method further includes receiving, via the processor, an updated movement plan from a server plan when a preset condition is met. Based on the updated movement plan, the method includes activating, via the processor, a second set of motorized tiles.

Abstract: Provided are ROR1 binding molecules, including anti-ROR1 antibodies, including antibody fragments such as variable heavy chain (VH) regions, single-chain fragments, and chimeric receptors including the antibodies, such as chimeric antigen receptors (CARs). In some embodiments, the antibodies specifically bind to ROR1. Among the antibodies are human antibodies, including those that compete for binding to ROR1 with reference antibodies, such as a non-human reference antibody. Also provided are genetically engineered cells expressing the chimeric receptors, and uses of the binding molecules and cells adoptive cell therapy.

Abstract: The present disclosure is generally directed to orally consumable products, such as foodstuffs and beverages, containing rebaudioside E present in, e.g., about 5 ppm to about 100 ppm, and to methods for preparing such orally consumable products.

Abstract: Described herein are systems and methods that search videos and other media content to identify items, objects, faces, or other entities within the media content. Detectors identify objects within media content by, for instance, detecting a predetermined set of visual features corresponding to the objects. Detectors configured to identify an object can be trained using a machine learned model (e.g., a convolutional neural network) as applied to a set of example media content items that include the object. The systems comprise an integrated detection unit configured to record media content, identify preferred content, and communicate the identifications of preferred content for storage in a computationally efficient manner.

Abstract: One variation of a method includes: accessing a boundary of a stand of trees; defining an array of scan zones within the boundary; accessing a first sequence of images representing treetops in a first scan zone; accessing a second sequence of images representing bases of trees in the first scan zone; accessing a third sequence of images representing bases of trees in a second scan zone; accessing a fourth sequence of images representing treetops in the second scan zone; interpolating canopy characteristics of trees between the first scan zone and the second scan zone based on the first and fourth sequences of images; interpolating lower tree characteristics of trees between the first scan zone and the second scan zone based on the second and third sequences of images; and compiling canopy and lower tree characteristics into a virtual representation of tree characteristics across the stand of trees.

Abstract: One variation of a method includes: accessing a boundary of a stand of trees; defining an array of scan zones within the boundary; accessing a first sequence of images representing treetops in a first scan zone; accessing a second sequence of images representing bases of trees in the first scan zone; accessing a third sequence of images representing bases of trees in a second scan zone; accessing a fourth sequence of images representing treetops in the second scan zone; interpolating canopy characteristics of trees between the first scan zone and the second scan zone based on the first and fourth sequences of images; interpolating lower tree characteristics of trees between the first scan zone and the second scan zone based on the second and third sequences of images; and compiling canopy and lower tree characteristics into a virtual representation of tree characteristics across the stand of trees.

Abstract: Described herein are systems and methods that search videos and other media content to identify items, objects, faces, or other entities within the media content. Detectors identify objects within media content by, for instance, detecting a predetermined set of visual features corresponding to the objects. Detectors configured to identify an object can be trained using a machine learned model (e.g., a convolutional neural network) as applied to a set of example media content items that include the object. The systems and methods describe techniques that search videos and media content to determine the presence of unknown objects, generate novel detectors trained to identify the unknown objects, and apply the novel detectors to historical media content to identify previous appearances of the unknown objects.

Abstract: A system and method for interrupting power in a three-phase power system interrupts power in the faulted phase and the next sequential phase at high speeds, while interrupting power in the remaining phase at a normal operation speed. Limiting high-speed interruption to only two phases requires significantly less energy storage than implementing high-speed interruption in all three phases. When hybrid circuit interrupters are used, the need to wait for a zero-crossing in the current signal in order to initiate interruption operations is eliminated.

Abstract: The present invention relates to a self-releasable safety belt for motorcycle or equivalent vehicles (100) comprising a lap belt (101) whereby both ends of said lap belt are affixed with a tongue connector (102), characterized in that, each of the tongue connector (102) is connected to a buckle (103) coupled to a swivel bracket (104), the swivel bracket (104) is fastened at both sides of the lower part of the vehicle's frame, the buckle (103) comprises a trigger button (105), the swivel bracket (104) comprises a pair of arms (107) which in parallel with the trigger button (105), wherein the lap belt (101) is fastened across the wearer's lap for holding the wearer in position during riding and whereby the trigger button (105) is triggered by the pair of arms (107) via swing force to detach the tongue connector (102) from the buckle (103) and release the lap belt (101) when the vehicle falls horizontally to ground to any direction.

Abstract: A system and method for interrupting power in a three-phase power system interrupts power in the faulted phase and the next sequential phase at high speeds, while interrupting power in the remaining phase at a normal operation speed. Limiting high-speed interruption to only two phases requires significantly less energy storage than implementing high-speed interruption in all three phases. When hybrid circuit interrupters are used, the need to wait for a zero-crossing in the current signal in order to initiate interruption operations is eliminated.

Abstract: The present invention relates, at least in part, to compounds and compositions that can be used to mask, block, or reduce the bitter taste present in various orally consumable products. The present invention also relates to methods of using bitterness blocking compounds and compositions to mask the bitterness of various orally consumable products, hence making such orally consumable products more palatable. The present invention further relates to an orally consumable product with reduced bitterness.