Abstract: Systems, devices and methods, etc., comprising anchors configured to attach to standing seams such as those typically present on metal roofs. The systems, etc., provide benefits such as improved anchorage points for personal fall protection anchorage devices and variability of and security of attachment to the standing seams. The personal fall protection anchorage devices can comprise a retention plate configured to hold the personal fall protection device to a central portion of the retention plate and having at least two y-axis spaced-apart slot configured to immobily hold opposed standing seam graspers each comprising at least two opposed grasping elements sized and configured to immobily squeeze standing seams of the metal roof.

Abstract: A method for providing directed transmission of sound waves, through modulation on an ultrasonic carrier, may comprise connecting, at least one directed sound source to an audio system, emitting, via the at least one directed sound source, audio from the audio system, wherein the emitting comprises emitting medium frequency audio sound waves and higher frequency audio sound waves. The audio may be selected via a master control unit, which may be operatively coupled to a mobile application. In many embodiments, a first audio selection is configured to be heard only through a first directed sound source, and a second audio selection is configured to be heard only through a second directed sound source.

Abstract: The present disclosure generally relates to improved synthesis of fused bicyclic Raf inhibitor enantiomers of formula (I), (Ia), (Ib), (II), (IIa), or (IIb), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, with high enantiomeric excess (% ee). The disclosure also relates to method of using the compound of formula (I), (Ia), (Ib), (II), (IIa), or (IIb), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, for treating diseases such as cancer, including colorectal cancer.

Abstract: A system, apparatus, and method of quickly inspecting tubes of chemical plants is provided, where one or more tube inspection apparatuses are used to simultaneously perform electromagnetic testing (“ET”) of multiple tubes of a chemical plant by simultaneously lowering probes into separate tubes and transmitting the data to a processor. In some embodiments, the data from the probes can be transmitted in real or near-real time to a remote processor for analysis to determine whether any defects exist in the tubes and the extent of such defects.

Abstract: An electrical device includes a first terminal structured to electrically connect to a power source; a second terminal structured to electrically connect to a load; a voltage sensor electrically connected to a point between the first and second terminals and being structured to sense a voltage at the point between the first and second terminals; a switch electrically connected between the first terminal and the second terminal; and a control unit structured to detect a power quality event in the power flowing between the first and second terminals based on the sensed voltage and to control a state of the switch based on the detected power quality event.

Abstract: The invention concerns compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein R1, R2 and n have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use as anti-proliferative and/or cell-killing agents.

Abstract: An electrical device includes a first terminal structured to electrically connect to a power source; a second terminal structured to electrically connect to a load; a voltage sensor electrically connected to a point between the first and second terminals and being structured to sense a voltage at the point between the first and second terminals; a switch electrically connected between the first terminal and the second terminal; and a control unit structured to detect a power quality event in the power flowing between the first and second terminals based on the sensed voltage and to control a state of the switch based on the detected power quality event.

Abstract: An apparatus for cleaning heat exchangers may include a cleaning lance for cleaning a plurality of bores of the heat exchanger and an examination lance for examining a plurality of bores of the heat exchanger. The apparatus may further include a first feeder configured to extend and retract the cleaning lance and a second feeder configured to extend and retract the examination lance. The apparatus may further include a controller. The controller may be configured to control the first feeder to feed the cleaning lance into a first bore, to control the cleaning lance to clean the first bore, and to control the first feeder to retract the cleaning lance from the first bore. The controller may be further configured to control the first feeder to extend the cleaning lance into a second bore, to control the cleaning lance to clean the second bore, to control the second feeder to extend the examination lance into the first bore, and to control the examination lance to examine the first bore.

Abstract: The invention concerns compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein R1, R2 and n have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use as anti-proliferative and/or cell-killing agents.

Abstract: A heat exchange system for heating, ventilation, and air conditioning (HVAC) may comprise a burner box, a hot collector box, and a heat exchanger tube. The heat exchanger tube may be disposed between, and in fluid communication with, the hot collector box and the burner box. The heat exchanger tube may be rigidly connected to at least one of the hot collector box or burner box by a swaged joint.

Abstract: A pipeline system for time-series data forecasting using a distributed computing environment is disclosed herein. In one example, a pipeline for forecasting time series is generated. The pipeline represents a sequence of operations for processing the time series to produce modeling results such as forecasts of the time series. The pipeline includes a segmentation operation for categorizing the time series into multiple demand classes based on demand characteristics of the time series. The pipeline also includes multiple sub-pipelines corresponding to the multiple demand classes. Each of the sub-pipelines applies a model strategy to the time series in the corresponding demand class. The model strategy is selected from multiple candidate model strategies based on predetermined relationships between the demand classes and the candidate model strategies. The pipeline is executed to determine the modeling results for the time series.

Abstract: An arc fault detection system includes a high frequency detector module structured to detect first spectral content of power having a frequency in a first frequency range, a number of arc fault circuit interrupters each having separable contacts, a low frequency detector module structured to detect second spectral content of power having a frequency in a second frequency range, a control unit structured to control the separable contacts to trip open, and an arc fault detection unit structured to detect an arc fault based on the detected first and second spectral content of the power and to cause the control unit to control the separable contacts to trip open in response to detecting the arc fault. A communication bus provides communication between the high frequency detector and the arc fault circuit interrupters and the first frequency range includes frequencies that are higher than frequencies in the second frequency range.

Abstract: A receptacle includes an outlet, an interruption mechanism structured to activate to de-energize the outlet, a temperature sensing circuit including a resistor and a thermistor arranged as a voltage divider, wherein the thermistor has a resistance proportional to temperature, a comparator circuit structured to compare an output of the temperature sensing circuit to a predetermined reference voltage and to selectively output a signal based on the comparison of the output of the temperature sensing circuit and the predetermined reference voltage. The interruption mechanism is structured to activate to de-energize the outlet in response to the comparator circuit outputting the signal.

Abstract: A pipeline system for time-series data forecasting using a distributed computing environment is disclosed herein. In one example, a pipeline for forecasting time series is generated. The pipeline represents a sequence of operations for processing the time series to produce modeling results such as forecasts of the time series. The pipeline includes a segmentation operation for categorizing the time series into multiple demand classes based on demand characteristics of the time series. The pipeline also includes multiple sub-pipelines corresponding to the multiple demand classes. Each of the sub-pipelines applies a model strategy to the time series in the corresponding demand class. The model strategy is selected from multiple candidate model strategies based on predetermined relationships between the demand classes and the candidate model strategies. The pipeline is executed to determine the modeling results for the time series.

Abstract: A circuit interrupter includes separable contacts, a trip actuator structured to cause the separable contacts to trip open, a conductor structured to carry power through the circuit interrupter, a sensor having a forward bias voltage drop inversely proportional to temperature and being disposed proximate the conductor, an amplifier circuit electrically connected to the sensor and being structured to amplify the forward bias voltage drop of the sensor, and a comparator circuit structured to compare the amplified forward bias voltage drop with a predetermined reference voltage and to output a signal to the trip actuator when the amplified forward bias voltage drop is less than or equal to the predetermined reference voltage. The signal causes the trip actuator to cause the separable contacts to trip open.

Abstract: A linearization circuit that reduces intermodulation distortion in an amplifier output receives a first signal that includes a first frequency and a second frequency and generates a difference signal having a frequency approximately equal to the difference of the first frequency and the second frequency. The linearization circuit generates an envelope signal based at least in part on a power level of the first signal and adjusts a magnitude of the difference signal based on the envelope signal. When the amplifier receives the first signal at an input terminal and the adjusted signal at a second terminal, intermodulation between the adjusted signal and the first signal cancels at least a portion of the intermodulation products that result from the intermodulation of the first frequency and the second frequency.

Abstract: The invention concerns compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein R1, R2 and n have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use as anti-proliferative and/or cell-killing agents.

Abstract: A tube clamp assembly for aligning and clamping a pair of tube ends includes: an elongate bar having a channel shaped to substantially conform to receive outer surfaces of adjacent tube ends when the channel is aligned parallel to a longitudinal axis of the adjacent tube ends, the elongate bar further including a bore oriented perpendicular to the longitudinal axis of the adjacent tube ends; a clamping member having an elongate body oriented parallel to the longitudinal axis of the adjacent tube ends, the clamping member having a bore formed therethrough, the bore substantially aligned with the bore of the elongate bar; at least one cable attached to the clamping member and extending around a distal outer wall of the adjacent tube ends; an elongate threaded bolt extending from a first end through the bore of the clamping member and into the bore of the bar member.

Abstract: A system, apparatus, and method of quickly inspecting tubes of chemical plants is provided, where one or more tube inspection apparatuses are used to simultaneously perform electromagnetic testing (“ET”) of multiple tubes of a chemical plant by simultaneously lowering probes into separate tubes and transmitting the data to a processor. In some embodiments, the data from the probes can be transmitted in real or near-real time to a remote processor for analysis to determine whether any defects exist in the tubes and the extent of such defects.