Patents by Inventor Steven Coats

Steven Coats has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION THERAPY
    Publication number: 20220218835
    Abstract: The disclosure relates to methods and compositions for the treatment of a B-cell malignancy. Specifically, the disclosure relates to a B-cell malignancy medicament or composition, comprising: (a) an antibody-drug conjugate (ADC) comprising an antibody or antigen-binding fragment thereof that binds to B-cell maturation antigen (BCMA), conjugated to a nucleic acid cross-linking agent; and (b) a proteasome inhibitor.
    Type: Application
    Filed: May 29, 2020
    Publication date: July 14, 2022
    Inventors: Krista KINNEER, David Alan TICE, Steven COATS, Yu-Tzu TAI, Kenneth ANDERSON
  • Bispecific HER2 antibodies
    Patent number: 10160812
    Abstract: The present invention relates to anti-HER2 binding molecules (e.g., antibodies and antigen binding fragments thereof), derived HER2-binding molecules (e.g., bispecific anti-HER2 antibodies), and antibody-drug conjugates (ADC) that bind the extracellular domain of the HER2 receptor. Also provided are pharmaceutical formulation comprising the disclosed compositions and method for the treating diseases associated with HER2-mediated signal transduction.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: December 25, 2018
    Assignee: MedImmune, LLC
    Inventors: John Li, Nazzareno Dimasi, Steven Coats, Melissa Damschroder, Changshou Gao, Godfrey Rainey, Cuihua Gao, Dorin Toader, Lakshmaiah Gingipalli, Fengjiang Wang, Ryan Fleming, Binyam Bezabeh, Andy Qingan Yuan, Srinath Kasturirangan
  • BISPECIFIC HER2 ANTIBODIES
    Publication number: 20170291955
    Abstract: The present invention relates to anti-HER2 binding molecules (e.g., antibodies and antigen binding fragments thereof), derived HER2-binding molecules (e.g., bispecific anti-HER2 antibodies), and antibody-drug conjugates (ADC) that bind the extracellular domain of the HER2 receptor. Also provided are pharmaceutical formulation comprising the disclosed compositions and method for the treating diseases associated with HER2-mediated signal transduction.
    Type: Application
    Filed: April 10, 2015
    Publication date: October 12, 2017
    Inventors: John Li, Nazzareno Dimasi, Steven Coats, Melissa Damschroder, Changshou Gao, Godfrey Rainey, Cuihua Gao, Dorin Toader, Lakshmaiah Gingipalli, Fengjiang Wang, Ryan Fleming, Binyam Bezabeh, Andy Qingan Yuan, Srinath Kasturirangan
  • Novel Cdk11 molecules and uses thereof
    Publication number: 20080050734
    Abstract: The present invention relates to a novel serine threonine kinase. The invention also relates to vector, host cells, antibodies and recombinant methods for producing the Cdk11 polypeptide. In addition, the invention discloses therapeutic, diagnostic and research utilities for Cdk11 and related products.
    Type: Application
    Filed: January 26, 2007
    Publication date: February 28, 2008
    Applicant: AMGEN INC.
    Inventors: Steven Coats, Peter Yakowec, Marc Payton
  • Prokineticin 2 receptor antagonists
    Publication number: 20080045535
    Abstract: The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 2 or prokinetin 2 receptor mediated disorders.
    Type: Application
    Filed: March 14, 2006
    Publication date: February 21, 2008
    Inventors: Steven Coats, Alexey Dyatkin, Wei He, Joseph Lisko, Tamara Miskowski, Janet Ralbovsky, Mark Schulz
  • Triazolopyrimidine derivatives
    Publication number: 20070015207
    Abstract: The invention relates to the discovery of triazolopyrimidine derivatives of formula (I), which have been found to exhibit inhibitory activity against the serine-tyrosine and tyrosine kinases.
    Type: Application
    Filed: January 11, 2006
    Publication date: January 18, 2007
    Inventors: Donald Ludovici, Richard Connors, Steven Coats, Li Liu, Bart De Corte, Dana Johnson, Mark Schulz
  • Prokineticin 1 receptor antagonists
    Publication number: 20060235018
    Abstract: The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.
    Type: Application
    Filed: March 14, 2006
    Publication date: October 19, 2006
    Inventors: Steven Coats, Alexey Dyatkin, Wei He, Joseph Lisko, Tamara Miskowski, Janet Ralbovsky, Mark Schulz
  • Tricyclic delta-opioid modulators
    Publication number: 20060148823
    Abstract: The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic ?-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
    Type: Application
    Filed: January 5, 2006
    Publication date: July 6, 2006
    Inventors: Steven Coats, Scott Dax, Bart DeCorte, Li Liu, Mark McDonnell, James McNally
  • Novel 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE)
    Publication number: 20060079686
    Abstract: The present invention is directed to novel 2-amino-3,4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of ?-secretase, also known as ?-site cleaving enzyme and BACE.
    Type: Application
    Filed: August 4, 2005
    Publication date: April 13, 2006
    Inventors: Ellen Baxter, Robert Boyd, Steven Coats, Alfonzo Jordan, Allen Reitz, Charles Reynolds, Malcolm Scott
  • Antibodies to cyclin E2 protein
    Publication number: 20050282150
    Abstract: Disclosed are nucleic acid molecules encoding novel cyclin E2 polypeptides. Also disclosed are methods of preparing the nucleic acid molecules and polypeptides, and methods of using these molecules.
    Type: Application
    Filed: July 28, 2005
    Publication date: December 22, 2005
    Applicant: Amgen Inc.
    Inventors: Steven Coats, Michael Bass, Murray Robinson
  • 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives
    Publication number: 20050004163
    Abstract: This invention is directed to 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives useful as ?-opioid or ?-opioid receptor modulators. Depending on their agonist or antagonist effect, the compounds are useful analgesics, immunosuppressants, antiinflammatory agents, agents for the treatment of neurological and psychiatric conditions, medicaments for drug and alcohol abuse, agents for treating gastritis and diarrhea, cardiovascular agents and agents for the treatment of respiratory diseases.
    Type: Application
    Filed: January 29, 2004
    Publication date: January 6, 2005
    Inventors: Steven Coats, John Carson, Lou Neilson, Philip Pitis, Mark Schulz
  • Novel amidoalkyl-piperidine and amidoalkyl-piperazine derivatives useful as neurokinin receptor modulators
    Publication number: 20050004136
    Abstract: Novel amidoalkyl-piperidine and amidoalkyl-piperazine derivatives of the general formula wherein all variables are as described herein, useful in the treatment of disorders, such as depression, dementia, schizophrenia, bipolar disorders, anxiety, emesis, acute or neuropathic pain, itching, migraine and movement disorders.
    Type: Application
    Filed: July 23, 2004
    Publication date: January 6, 2005
    Inventors: Kevin Pan, Michael Parker, Allen Reitz, Steven Coats, Cheryl Kordik, Chi Luo