Patents by Inventor Steven Colin Beasley

Steven Colin Beasley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purine and guanine derivatives as PNP inhibitors
    Patent number: 5912252
    Abstract: The subject invention concerns compounds of formula (I): whereinn=1 or 2;R.sup.1 is H, NH.sub.2 or halogen;R.sup.2 is H or NH.sub.2 ;R.sup.3 represents the group CR.sup.6 R.sup.7 R.sup.8 where R.sup.6, R.sup.7 and R.sup.8 are the same or different and are each H, C.sub.1-6 alkyl or C.sub.1-6 haloalkyl;R.sup.4 and R.sup.5 are the same or different and are selected from the group consisting of H, CO.sub.2 H, CO.sub.2 C.sub.1-6, NHSO.sub.2 CF.sub.3, tetrazole and (CR.sup.9 R.sup.10).sub.p (Y).sub.q (CR.sup.9 R.sup.10).sub.t Z where (CR.sup.9 R.sup.10), or (CR.sup.9 R.sup.10).sub.t is straight or branched chain bearing the substituents R.sup.9 and R.sup.10 when p or t>1;R.sup.9 and R.sup.10 are the same or different and are each C.sub.0-6 alkyl-Z;p=1-3;q=0 or 1;t=0-4, provided that t>0 when q=1;Y=O, NH or S(O).sub.m where m=0-2; andZ is selected from a group consisting of H, CN, CO.sub.2 H, CO.sub.2 C.sub.1-6 alkyl, NHSO.sub.2 CF.sub.3 tetrazole, triazole, CONH.sub.2, CON(C.sub.1-6 alkyl).sub.2, CONH(C.sub.
    Type: Grant
    Filed: May 19, 1997
    Date of Patent: June 15, 1999
    Assignee: Darwin Discovery Limited
    Inventors: Steven Colin Beasley, John Gary Montana
  • Quinolones and their therapeutic use
    Patent number: 5891878
    Abstract: 1-Alkyl-substituted-quinolone-3-carboxamides have therapeutic utility via inhibition of Phosphodiesterase IV esterase and/or Tumour Necrosis Factor activity. The compounds of the invention have the general formula (I): ##STR1## The compounds of the invention encompassed by formula (I) include enantiomers, diastereoisomers and mixtures, including racemic mixtures.
    Type: Grant
    Filed: August 2, 1996
    Date of Patent: April 6, 1999
    Assignee: Chiroscience Limited
    Inventors: Steven Colin Beasley, John Gary Montana, Hazel John Dyke, Alan Findlay Haughan, Karen Ann Runcie, David Thomas Manallack, George Martin Buckley, Robert James Maxey, Hannah Jayne Kendall, Andrew Douglas Baxter
  • Purine and guanine derivatives
    Patent number: 5863921
    Abstract: Compounds of formula (I) ##STR1## wherein n=1 or 2;R.sup.1 is H, NH.sub.2 or halogen;R.sup.2 is H or NH.sub.2 ;R.sup.3 represents the group ##STR2## where m=0 or 1; R.sup.4 and R.sup.5 are the same or different and are each H, CO.sub.2 H, CO.sub.2 C.sub.1-6 alkyl, NHSO.sub.2 CF.sub.3, tetrazole, (CR.sup.6 R.sup.7).sub.p (Y).sub.q (CR.sup.6 R.sup.7).sub.t Z where (CR.sup.6 R.sup.7)p or (CR.sup.6 R.sup.7).sub.t may be straight or branched chain bearing the substituents R.sup.6 and R.sup.7 when p and t>1; R.sup.6 and R.sup.7 are the same or different and are each C.sub.0-6 alkyl-Z;p=1-3;q=0 or 1;t=0-4, provided that t>0 wgeb q=1;Y is NH, O, S(O)u where u=0-2;Z is H, CN, CO.sub.2 H, CO.sub.2 C.sub.1-6 alkyl, NHSO.sub.2 CF.sub.3, tetrazole, triazole, CONH.sub.2, CON(C.sub.1-6 alkyl).sub.2, CONH(C.sub.1-6 alkyl), SO.sub.2 NH (C.sub.1-6 alkyl) or SO.sub.2 N(C.sub.1-6 alkyl).sub.2 ; or a salt, soluate or hydrate thereof.
    Type: Grant
    Filed: May 19, 1997
    Date of Patent: January 26, 1999
    Assignee: Darwin Discovery Limited
    Inventors: Steven Colin Beasley, John Gary Montana, David Thomas Manallack
  • Quinolones and their therapeutic use
    Patent number: 5792774
    Abstract: A compound of formula (I) ##STR1## or a pharmaceutically-acceptable salt, solvate or hydrate thereof.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: August 11, 1998
    Assignee: Chiroscience Limited
    Inventors: Alan Findlay Haughan, Steven Colin Beasley, John Gary Montana, Robert John Watson
  • Quinolones and their therapeutic use
    Patent number: 5753666
    Abstract: 1-Alkyl-substituted-quinolone-3-carboxamides have therapeutic utility via inhibition of Phosphodiesterase IV esterase and/or Tumor Necrosis Factor activity.
    Type: Grant
    Filed: August 2, 1996
    Date of Patent: May 19, 1998
    Assignee: Chiroscience Limited
    Inventors: Steven Colin Beasley, John Gary Montana, Hazel Joan Dyke, Alan Findlay Haughan, George Martin Buckley, Andrew Douglas Baxter
  • Hypoxanthine and guanine compounds
    Patent number: 5736549
    Abstract: Compounds of formula I ##STR1## where n=0-2;R.sup.1 is H, NH.sub.2 or a halogen;R.sup.2 is H or NH.sub.2 ;R.sup.3 is any of the four groups ##STR2## where m=0 or 1; andX is O, NR.sup.5, or S(O).sub.0-2 and, in group (b), the X's may be the same or different.Compounds of the invention have utility as inhibitors of purine nucleoside phosphyorylase (PNP).
    Type: Grant
    Filed: October 5, 1995
    Date of Patent: April 7, 1998
    Assignee: Chiroscience Limited
    Inventors: Steven Colin Beasley, Alan Findlay Haughan, John Montana, Robert John Watson