Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: In an embodiment, an apparatus comprises one or more processors and one or more memories communicatively coupled to the one or more processors and storing instructions which, when processed by the one or more processors, cause: providing one or more first software services to a client computing device corresponding to a particular entity profile for a particular entity; identifying data in the particular entity profile identifying one or more second software services used by the particular entity; while executing a first workflow for the one or more first software services, identifying a trigger for the one or more second software services; in response to identifying the trigger, executing a second workflow for the one or more second software services using data extracted from the first workflow.

Abstract: Disclosed are technologies for robotic transport of one or more items of payload, including a configurable door assembly for a storage compartment of a robot.

Abstract: System, methods, and apparatuses are provided for energy management in store or dispense equipment for food and/or beverages. Such store or dispense equipment may allow for food and/or beverages to be heated, cooled, or maintained near the ambient temperature, or a combination thereof. Demand data may be retrieved from the store or dispense equipment. Demand data may include sales, usage, and/or occupancy information for the respective vending machines, appliances, coolers, dispensers, and other store or dispense equipment. This demand data may then analyzed to determine whether there are demand patterns such that there are opportunities for energy conservation or energy management. If there are opportunities for energy conservation or energy management, an instruction set may be prepared, where the instruction set is based at least in part on this analyzed data. The instruction set is loaded onto the store or dispense equipment, which operates in accordance with the instruction set.

Abstract: The present invention provides systems, methods, and apparatuses for energy management in store or dispense equipment for food and/or beverages. Such store or dispense equipment may allow for food and/or beverages to be heated, cooled, or maintained near the ambient temperature, or a combination thereof. The store or dispense equipment may include vending machines, appliances, coolers, dispensers such as food dispensers and beverage dispensers (e.g., fountain drink dispenser), and other like electrical equipment. Demand data may be retrieved from the vending machine, appliance, cooler, dispenser, or other store or dispense equipment. Demand data may include sales, usage, and/or occupancy information for the respective vending machines, appliances, coolers, dispensers, and other store or dispense equipment. This demand data may then analyzed to determine whether there are demand patterns such that there are opportunities for energy conservation or energy management.

Abstract: A machine and method for moulding a composite of complex nodal structure includes laying down under CNC a reinforcement (38) of constant cross-section repeatedly into and along channels (26) of a mold (24) and through nodes of the structure, closing the mold, impregnating it with resin and curing the resin.