Patents by Inventor Steven D. Blotner

Steven D. Blotner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR PERSONALIZING PATIENT CANCER THERAPY WITH AN MDM2 ANTAGONIST
    Publication number: 20170227544
    Abstract: The present application discloses a method to predict responsiveness of a patient, with cancer, to treatment with an MDM2 antagonist of formulae I, II and III as disclosed herein, said method comprising a multivariate analysis comprising detecting relative amounts of certain MDM2 protein expressing cells and, optionally additional co-variates selected from a gene signature as disclosed herein, p53 mutation status, the patient's age and ECOG score at baseline as a biomarker for predicting said patient's response to treatment.
    Type: Application
    Filed: October 7, 2015
    Publication date: August 10, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Steven D. Blotner, Gong Chen, Lori Jukofsky, Gwen Nichols, William E. Pierceall, Bernhard Reis, Ruediger Rueger, Hua Zhong