Patents by Inventor STEVEN D. DOIG
STEVEN D. DOIG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11866713Abstract: The present disclosure is generally related to compositions and methods for obtaining Bacillus licheniformis cells/strains having increased protein production capabilities. Certain embodiments of the disclosure are related to genetically modified Bacillus licheniformis cells/strains derived from parental B. licheniformis cells/strains comprising a variant rghR2 gene.Type: GrantFiled: February 22, 2018Date of Patent: January 9, 2024Assignee: DANISCO US INC.Inventors: Marc Anton Bernhard Kolkman, Steven D. Doig, Ryan L. Frisch, Hongxian He, Frank Wouter Koopman, Chris Leeflang
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Publication number: 20230340442Abstract: The present disclosure is generally related to compositions and methods for constructing and/or obtaining B. licheniformis cells (e.g., protein production hosts) comprising enhanced protein production capabilities. Thus, certain embodiments are related to genetically modified Bacillus licheniformis strains derived from parental B. licheniformis strains producing increased amounts of one or more proteins of interest.Type: ApplicationFiled: January 14, 2021Publication date: October 26, 2023Inventors: Steven D. Doig, Ryan L. Frisch, Hongxian He, Chris Leeflang, Zhen Ma, Brian James Paul
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Publication number: 20200056193Abstract: The present disclosure is generally related to compositions and methods for obtaining Bacillus licheniformis cells/strains having increased protein production capabilities. Certain embodiments of the disclosure are related to genetically modified Bacillus licheniformis cells/strains derived from parental B. licheniformis cells/strains comprising a variant rghR2 gene.Type: ApplicationFiled: February 22, 2018Publication date: February 20, 2020Inventors: Marc Anton Bernhard Kolkman, Steven D. Doig, Ryan L. Frisch, Hongxian He, Frank Wouter, Chris Leeflang
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Patent number: 10308910Abstract: Provided herein are processes for producing an improved culture of cells comprising an engineered butanol biosynthetic pathway. The processes comprise (a) providing a cell culture of recombinant microorganisms comprising an engineered butanol biosynthetic pathway, wherein the engineered butanol biosynthetic pathway is minimal or not activated; and (b) growing the culture of recombinant microorganisms under adaptive conditions whereby pathway activation is increased to produce an improved cell culture and whereby the improved cell culture is capable of continuing to grow in fermentation.Type: GrantFiled: April 20, 2017Date of Patent: June 4, 2019Assignee: Butamax Advanced Biofuels LLCInventors: Ritu Bhalla, Steven D. Doig, Kakasaheb Suresh Konde, Ranjan Patnaik
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Publication number: 20170283765Abstract: Provided herein are processes for producing an improved culture of cells comprising an engineered butanol biosynthetic pathway. The processes comprise (a) providing a cell culture of recombinant microorganisms comprising an engineered butanol biosynthetic pathway, wherein the engineered butanol biosynthetic pathway is minimal or not activated; and (b) growing the culture of recombinant microorganisms under adaptive conditions whereby pathway activation is increased to produce an improved cell culture and whereby said improved cell culture is capable of continuing to grow in fermentation.Type: ApplicationFiled: April 20, 2017Publication date: October 5, 2017Inventors: Ritu Bhalla, STEVEN D. DOIG, KAKASAHEB SURESH KONDE, RANJAN PATNAIK
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Patent number: 9663759Abstract: Provided herein are processes for producing an improved culture of cells comprising an engineered butanol biosynthetic pathway. The processes comprise (a) providing a cell culture of recombinant microorganisms comprising an engineered butanol biosynthetic pathway, wherein the engineered butanol biosynthetic pathway is minimal or not activated; and (b) growing the culture of recombinant microorganisms under adaptive conditions whereby pathway activation is increased to produce an improved cell culture and whereby the improved cell culture is capable of continuing to grow in fermentation.Type: GrantFiled: July 1, 2014Date of Patent: May 30, 2017Assignee: Butamax Advanced Biofuels LLCInventors: Ritu Bhalla, Steven D. Doig, Kakasaheb Suresh Konde, Ranjan Patnaik
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Patent number: 9249076Abstract: Provided herein are processes comprising providing a fermentation medium comprising a fermentable carbon source, a recombinant microorganism comprising an engineered butanol biosynthetic pathway, and butanol; contacting said fermentation medium with an extractant composition comprising an effective amount of antioxidant or antioxidant-like compound, whereby at least a portion of the butanol in the fermentation medium partitions into the extractant; recovering at least a portion of the butanol and extractant composition from the fermentation medium; recycling the extractant composition recovered in (c) one or more times in the fermentation medium; optionally adjusting the effective amount of antioxidant or antioxidant-like compound in the extractant composition, whereby the rate of oxidation or effect of oxidized products in the recycled extractant composition is substantially reduced and/or avoided such that the extractant composition may be recycled.Type: GrantFiled: September 20, 2013Date of Patent: February 2, 2016Assignee: BUTAMAX ADVANCED BIOFUELS LLCInventors: Douglas Robert Anton, Bruce A. Diner, Steven D. Doig
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Publication number: 20150010984Abstract: Provided herein are processes for producing an improved culture of cells comprising an engineered butanol biosynthetic pathway. The processes comprise (a) providing a cell culture of recombinant microorganisms comprising an engineered butanol biosynthetic pathway, wherein the engineered butanol biosynthetic pathway is minimal or not activated; and (b) growing the culture of recombinant microorganisms under adaptive conditions whereby pathway activation is increased to produce an improved cell culture and whereby said improved cell culture is capable of continuing to grow in fermentation.Type: ApplicationFiled: July 1, 2014Publication date: January 8, 2015Inventors: Ritu Bhalla, Steven D. Doig, Kakasaheb Suresh Konde, Ranjan Patnaik
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Publication number: 20140142352Abstract: Provided herein are processes for adjusting a fermentation medium to reduce the activity of one or more carboxylic acids. The processes comprise (a) providing a recombinant microorganism comprising an engineered butanol biosynthetic pathway, (b) contacting the recombinant microorganism with a fermentation medium whereby butanol is produced and wherein the fermentation medium comprises one or more carboxylic acids, and (c) adjusting the fermentation medium to reduce the activity of the one or more carboxylic acids. Also provided are processes for reducing the activity of one or more carboxylic acids in a feed. The processes comprise (a) providing a feed from a fermentation vessel, wherein the feed comprises a composition produced by a recombinant microorganism comprising an engineered butanol biosynthetic pathway, wherein the composition comprises butanol, water, and one or more carboxylic acids; and (b) adjusting the feed, wherein adjusting the feed reduces the activity of the one or more carboxylic acids.Type: ApplicationFiled: November 20, 2013Publication date: May 22, 2014Applicant: BUTAMAX ADVANCED BIOFUELS LLCInventors: MICHAEL DAUNER, Robert Dicosimo, Steven D. Doig, Adam David Henry, Joseph J. Zaher
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Publication number: 20140094630Abstract: Provided herein are processes comprising providing a fermentation medium comprising a fermentable carbon source, a recombinant microorganism comprising an engineered butanol biosynthetic pathway, and butanol; contacting said fermentation medium with an extractant composition comprising an effective amount of antioxidant or antioxidant-like compound, whereby at least a portion of the butanol in the fermentation medium partitions into the extractant; recovering at least a portion of the butanol and extractant composition from the fermentation medium; recycling the extractant composition recovered in (c) one or more times in the fermentation medium; optionally adjusting the effective amount of antioxidant or antioxidant-like compound in the extractant composition, whereby the rate of oxidation or effect of oxidized products in the recycled extractant composition is substantially reduced and/or avoided such that the extractant composition may be recycled.Type: ApplicationFiled: September 20, 2013Publication date: April 3, 2014Applicant: BUTAMAX(TM) ADVANCED BIOFUELS LLCInventors: DOUGLAS ROBERT ANTON, BRUCE A. DINER, STEVEN D. DOIG