Patents by Inventor Steven D. Flanagan

Steven D. Flanagan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Candidate region mismatch scanning for genotyping and mutation detection
    Publication number: 20020146723
    Abstract: Use of the E. coli mismatch detection system, MutS, MutL and MutH, in PCR-based, automated, high-throughput genotyping and mutation detection of genomic DNA. Optimal sensitivity and signal-to-noise ratios are dependent upon monovalent cation concentration and MutL concentration. Strategies that can be easily adapted to automation for limiting the analysis to intersample heteroduplexes have been developed.
    Type: Application
    Filed: October 25, 2001
    Publication date: October 10, 2002
    Inventors: Theodore G. Krontiris, Martin Beaulieu, Steven D. Flanagan
  • Disease association by stratification
    Publication number: 20020034742
    Abstract: Pathogenetic allele variants that predispose to a disease can be identified by stratifying affected sib pairs by allele-sharing statuss at two or more candidate loci. This locus stratification method has been used to identify an allelic variant at the ATM locus which is implicated in breast cancer.
    Type: Application
    Filed: March 5, 2001
    Publication date: March 21, 2002
    Applicant: CITY OF HOPE
    Inventors: Theodore G. Krontiris, Garry P. Larson, Steven D. Flanagan
  • Disease association by locus stratification
    Patent number: 6248524
    Abstract: Pathogenetic allele variants that predispose to a disease can be identified by stratifying affected sib pairs by allele-sharing statuss at two or more candidate loci. This locus stratification method has been used to identify an allelic variant at the ATM locus which is implicated in breast cancer.
    Type: Grant
    Filed: September 28, 1998
    Date of Patent: June 19, 2001
    Assignee: City of Hope
    Inventors: Theodore G. Krontiris, Garry P. Larson, Steven D. Flanagan