Abstract: Disclosed are approaches to determining a sensitivity of a bacterium to a given antibiotic and generating targeted treatments based on the sensitivity. One or more antibiotics may be selected for a chronic/recurrent infection resulting from a biofilm so as to reduce dose and or length of course of antibiotic treatment. For example, if a bacterial pathogen is determined to be sensitive to an antibiotic in its planktonic form but resistant to that antibiotic in its biofilm form, then the biofilm may be dispersed or disrupted from the biofilm residence in order to clear the infection. In various embodiments, a dispersal or disruption method and/or agent may be determined based at least in part on a rate of bacterial release from a biofilm that sensitizes the pathogen to a chosen antibiotic.

Abstract: An iterative attention-based neural network training and processing method and system iteratively applies a focus of attention of a trained neural network on syntactical elements and generates probabilities associated with representations of the syntactical elements, which in turn inform a subsequent focus of attention of the neural network, resulting in updated probabilities. The updated probabilities are then applied to generate syntactical elements for delivery to a user. The user may respond to the delivered syntactical elements, providing additional training information to the trained neural network.

Abstract: A method and system are provided to facilitate statement acquisition and verification pertaining to an incident. One or more processors are operationally coupled to one or more software modules, configured to: receive audio data between a suspect and an officer at a portable radio, detect a pre-Miranda statement made by the suspect within the audio data; detect a Miranda warning made by the officer within the audio data; detect a waiving of Miranda rights by the suspect within the audio data; detect a post-Miranda statement by the suspect within the audio data after the waiving of Miranda rights; determine when a degree of semantic similarity between the pre-Miranda statement and the post-Miranda statement fails to satisfy an admissibility condition; generate one or more questions to induce the suspect to repeat the pre-Miranda statement; and present the one or more questions to an electronic user interface.

Abstract: Methods and systems provided for generating a soil data map. One example method includes instructing, by a computing device, a user to draw a field boundary in a map of a geographic area and receiving an input, from the user, at the map of the geographic area, where the input includes multiple vertices of the field boundary. The method also includes appending, by the computing device, a shape of the field boundary to the map, based on the multiple vertices, and overlaying at least one management zone within the field boundary on the map. The at least one management zone is associated with specific soil data for the geographic area corresponding to the at least one management zone within the field boundary.

Abstract: The disclosure provides at least one compound, tautomer, deuterated derivative, or pharmaceutically acceptable salt chosen from compounds of Formula I, tautomers thereof, deuterated derivatives of those compounds or tautomers, and pharmaceutically acceptable salts of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD).

Abstract: An apparatus for physically securing a tablet and a keyboard includes a main body, a left arm, a right arm a front arm and a top arm. The front arm extends from the main body to secure the front of the keyboard and has a first latching ratchet mechanism that prevents extension of the front arm in a first configuration of the first latching ratchet mechanism and enables extension of the front arm in a second configuration of the first latching ratchet mechanism. The top arm has a second latching ratchet mechanism that prevents extension of the top arm in a first configuration of the second latching ratchet mechanism and enables extension of the top arm in a second configuration of the second latching ratchet mechanism.

Abstract: A machine may include a frame and a lift system. The lift system may include a lift arm attached to the frame. The lift arm may be configured to actuate between a raised position and a lowered position. The lift system may include a roller attached to the frame. The machine may include a power unit including an energy storage unit and a power unit housing containing the energy storage unit. The power unit housing may include an engagement element configured to engage the power unit housing with the lift arm. The power unit housing may include a cam element, projecting from the power unit housing, configured to slidably engage with the roller during actuation of the lift arm.

Abstract: Some embodiments provide hydro-power generation systems for irrigation systems. In some embodiments, a system comprises a generator comprising a turbine at least partially inserted into a fluid flow path of a conduit of the irrigation system and to be activated by a fluid flow in the conduit, wherein the generator is to output an electrical power signal; a control circuit to: determine a characteristic of the electrical power signal; determine, based on the characteristic, a load impedance selected from a plurality of load impedances; and output a control signal to select the load impedance. The system also comprises a variable load circuit to: receive the control signal; and provide the load impedance, where an impedance of the variable load circuit is based on the characteristic to provide power generation over various flow rates of fluid in the fluid flow path.

Abstract: The present application discloses compounds having the following formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and X are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

Abstract: A joint mounting kit comprises a mounting plate and slugs to enhance adjustability of the vehicle suspension system. A fastener is configured to be received in the mounting hole to at least partially retain the mounting plate to a vehicle component, and a slug is configured to be received in the mounting hole with the fastener. The slug has a slug height that is equal to or less than a height of the mounting hole interior wall. In another implementation, the joint mounting kit comprises a plurality of slugs, with two or more slugs having different wheel adjustment dimensions. In yet another implementation, the slug has a tool removal recess to help facilitate slug removal.

Abstract: A joint mounting kit comprises a mounting plate and slugs to enhance adjustability of the vehicle suspension system. A fastener is configured to be received in the mounting hole to at least partially retain the mounting plate to a vehicle component, and a slug is configured to be received in the mounting hole with the fastener. The slug has a slug height that is equal to or less than a height of the mounting hole interior wall. In another implementation, the joint mounting kit comprises a plurality of slugs, with two or more slugs having different wheel adjustment dimensions. In yet another implementation, the slug has a tool removal recess to help facilitate slug removal.

Abstract: An apparatus for physically securing a tablet and a keyboard includes a main body, a left arm, a right arm a front arm and a top arm. The front arm extends from the main body to secure the front of the keyboard and has a first latching ratchet mechanism that prevents extension of the front arm in a first configuration of the first latching ratchet mechanism and enables extension of the front arm in a second configuration of the first latching ratchet mechanism. The top arm has a second latching ratchet mechanism that prevents extension of the top arm in a first configuration of the second latching ratchet mechanism and enables extension of the top arm in a second configuration of the second latching ratchet mechanism.

Abstract: PGM converting process and jacketed rotary converter. The process can include low- or no-flux converting; partial pre-oxidation of PGM collector alloy; using a refractory protectant in the converter; magnetic separation of slag; recycling part of the slag to the converter; smelting catalyst material in a primary furnace to produce the collector alloy; and/or smelting the converter slag in a secondary furnace with slag from the primary furnace. The converter can include an inclined converter pot mounted for rotation; a refractory lining; an opening in a top of the pot to introduce converter feed; a lance for injecting oxygen-containing gas into the alloy pool; a heat transfer jacket adjacent the refractory lining; and a coolant system to circulate a heat transfer medium through the jacket to remove heat from the alloy pool in thermal communication with the refractory lining.

Abstract: A hot melt adhesive composition comprises a polymer comprising poly(?-methyl-?-propiolactone) (PMPL) or a derivative thereof, wherein the PMPL is polymerized from a plurality of (R)-?-methyl-?-propiolactone monomers and a plurality of (S)-?-methyl-?-propiolactone monomers, wherein the ratio of (R):(S) monomers is from about 90:10 to about 10:90. Changing the (R):(S) ratio impacts the isotactic diad fraction and consequently the crystallinity and thermomechanical properties of the resulting PMPL. The PMPL may be hydroxyl-terminated, with the residue thereof serving as the elastomeric B block in an A:B:A triblock copolymer having hard end A blocks, such as a residue of polylactic acid. The PMPL diol may also be used as a reactant to form an alkoxysilane-terminated polymer, a polyurethane, or a (co)polyester. In some embodiments, such triblock polymers may be entirely bio-sourced and compostable.

Abstract: The present application discloses compounds having the following formula: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4 are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

Abstract: Some embodiments provide an irrigation flow sensor system, comprising: a housing forming a fluid channel to cooperate with conduits of an irrigation system; a paddle wheel device with at least a first blade of a set of the blades comprises a magnetic element; the paddle wheel device is positioned with at least a portion of the blades extends into the fluid channel as the blades rotate about an axis; a magnetic sensor proximate a pathway of the magnetic element as it rotates configured to provide a sensor output every time the magnetic element passes the magnetic sensor; a switch coupled to the magnetic sensor and a current loop, wherein the switch in an activate state is configured to temporarily change the current in the current loop in response to the sensor output, with a rate of change in current corresponding to a flow rate of the fluid flowing.

Abstract: The disclosure provides at least one compound, tautomer, deuterated derivative, or pharmaceutically acceptable salt chosen from compounds of Formula I, tautomers thereof, deuterated derivatives of those compounds or tautomers, and pharmaceutically acceptable salts of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD).

Abstract: This invention relates to a new and distinct variety of strawberry plant named ‘PS-13.467.089’. This new strawberry plant named ‘PS-13.467.089’ is primarily adapted to the growing conditions of the central coast of California, and is primarily characterized by its fruit that is orange red to red in color, medium in size and very uniformly shaped; its fruit has very good flavor with the seeds held even with the surface of the fruit; the plant is very large in size, very early fruiting with very high yields; its foliage is light yellow green in color, medium in size with three leaflets; its fruiting trusses are typically held level to beneath the foliage, with weak pubescence and strong anthocyanins; and the plant is resistant to Fusarium wilt.