Patents by Inventor Steven D. Hume
Steven D. Hume has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11696948Abstract: Disclosed herein are methods of forming compounds and exemplary compounds in the nature of a conjugated compound, which in some embodiments comprises an antigen and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for use of the conjugate mixture as a vaccine, including but not limited to use as a vaccine against various pathogens including for treatment of diseases caused by novel coronaviruses (including SARS-COV 2).Type: GrantFiled: July 2, 2020Date of Patent: July 11, 2023Assignee: KBIO HOLDINGS LIMITEDInventors: Steven D. Hume, Leigh Burden, Joshua Morton, Greg Pogue, Barry Bratcher, Hugh A. Haydon, Carrie A. Simpson, Nick Partain, Youngjun Oh, John W. Shepherd, Michael H. Pauly
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Patent number: 11690907Abstract: Disclosed herein are methods of forming compounds and exemplary stable compounds in the nature of a conjugated compound at refrigerated or room temperature, which in some embodiments comprises an antigen and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for use of the conjugate mixture as a vaccine, including but not limited to use as a vaccine against various pathogens including for treatment of diseases caused by novel coronaviruses (including SARS-COV 2).Type: GrantFiled: February 26, 2021Date of Patent: July 4, 2023Assignee: KBIO HOLDINGS LIMITEDInventors: Steven D. Hume, Leigh Burden, Joshua Morton, Greg Pogue, Barry Bratcher, Hugh A. Haydon, Carrie A. Simpson, Nick Partain, Youngjun Oh, John W. Shepherd, Michael H. Pauly
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Patent number: 11655461Abstract: Disclosed herein are methods and exemplary compositions associated with antigen purification, exemplary aspects of which may include harvesting viral and antigenic substances from source organisms; and a purification platform comprising chemical separation and size-difference separation for the removal of contaminants, debris and impurities from the viral and protein (e.g. antigenic, including influenza hemagglutinin antigens) substances, as well as their concentration and collection.Type: GrantFiled: October 5, 2020Date of Patent: May 23, 2023Assignee: KBIO HOLDINGS LIMITEDInventors: Steven D. Hume, Leigh Burden, Joshua Morton, Greg Pogue, Barry Bratcher, Hugh A. Haydon, Carrie A. Simpson, Nick Partain, John W. Shepherd, Kelsi Swope
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Publication number: 20230149532Abstract: Disclosed herein are methods of forming compounds and exemplary stable compounds in the nature of a conjugated compound at refrigerated or room temperature, which in some embodiments comprises an antigen and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for use of the conjugate mixture as a vaccine, including but not limited to use as a vaccine against various pathogens including for treatment of diseases caused by novel coronaviruses (including SARS-COV 2).Type: ApplicationFiled: June 28, 2022Publication date: May 18, 2023Applicant: KBIO HOLDINGS LIMITEDInventors: Steven D. Hume, Leigh Burden, Joshua Morton, Greg Pogue, Barry Bratcher, Hugh A. Haydon, Carrie A. Simpson, Nick Partain, Youngjun Oh, John W. Shepherd, Michael H. Pauly
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Publication number: 20230056944Abstract: Disclosed herein are methods of forming compounds and exemplary compounds in the nature of a conjugated compound demonstrating enhanced stability, which in some embodiments comprises a protein and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for unrefrigerated storage for longer time periods than previous approaches, thus making feasible access to such products over a global supply chain.Type: ApplicationFiled: October 17, 2022Publication date: February 23, 2023Applicant: KBIO Holdings LimitedInventors: Leigh Burden, Steven D. Hume, Joshua Morton, Greg Pogue, Barry Bratcher, Hugh A. Haydon, Carrie A. Simpson, Nick Partain, John W. Shepherd
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Publication number: 20230027693Abstract: Disclosed herein are methods and exemplary compositions associated with virus purification, antigen purification, and conjugation of virus and proteins (e.g., antigen) to form vaccines for delivery of immunological and other therapeutic agents, exemplary aspects of which may include harvesting viral and antigenic substances from source organisms; a purification platform comprising chemical separation and size-difference separation for the removal of contaminants, debris and impurities from the viral and protein (e.g. antigenic, including influenza hemagglutinin antigens) substances, as well as their concentration and collection; and a conjugation platform providing activation of the virus at a pH that increases binding rate and binding propensity between the virus and the protein, wherein embodiments related to the conjugation platform include controlling the ratio of virus to protein.Type: ApplicationFiled: September 23, 2022Publication date: January 26, 2023Applicant: KBIO HOLDINGS LIMITEDInventors: Leigh Burden, Steven D. Hume, Joshua Morton, Greg Pogue, Barry Bratcher, Hugh A. Haydon, Carrie A. Simpson, Nick Partain, John W. Shepherd
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Patent number: 11529413Abstract: Disclosed herein are methods of forming compounds and exemplary compounds in the nature of a conjugated compound demonstrating enhanced stability, which in some embodiments comprises a protein and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for unrefrigerated storage for longer time periods than previous approaches, thus making feasible access to such products over a global supply chain.Type: GrantFiled: December 10, 2019Date of Patent: December 20, 2022Assignee: KBIO HOLDINGS LIMITEDInventors: Leigh Burden, Steven D. Hume, Joshua Morton, Greg Pogue, Barry Bratcher, Hugh A. Haydon, Carrie A. Simpson, Nick Partain, John W. Shepherd
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Patent number: 11485956Abstract: Disclosed herein are methods and exemplary compositions associated with virus purification, antigen purification, and conjugation of virus and proteins (e.g., antigen) to form vaccines for delivery of immunological and other therapeutic agents, exemplary aspects of which may include harvesting viral and antigenic substances from source organisms; a purification platform comprising chemical separation and size-difference separation for the removal of contaminants, debris and impurities from the viral and protein (e.g. antigenic, including influenza hemagglutinin antigens) substances, as well as their concentration and collection; and a conjugation platform providing activation of the virus at a pH that increases binding rate and binding propensity between the virus and the protein, wherein embodiments related to the conjugation platform include controlling the ratio of virus to protein.Type: GrantFiled: June 11, 2019Date of Patent: November 1, 2022Assignee: KBIO HOLDINGS LIMITEDInventors: Leigh Burden, Steven D. Hume, Joshua Morton, Greg Pogue, Barry Bratcher, Hugh A. Haydon, Carrie A. Simpson, Nick Partain, John W. Shepherd
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Publication number: 20210236624Abstract: Disclosed herein are methods of forming compounds and exemplary stable compounds in the nature of a conjugated compound at refrigerated or room temperature, which in some embodiments comprises an antigen and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for use of the conjugate mixture as a vaccine, including but not limited to use as a vaccine against various pathogens including for treatment of diseases caused by novel coronaviruses (including SARS-COV 2).Type: ApplicationFiled: February 26, 2021Publication date: August 5, 2021Applicant: Kentucky BioProcessing, Inc.Inventors: Steven D. Hume, Leigh Burden, Joshua Morton, Greg Pogue, Barry Bratcher, Hugh A. Haydon, Carrie A. Simpson, Nick Partain, Youngjun Oh, John W. Shepherd, Michael H. Pauly
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Publication number: 20210017502Abstract: Disclosed herein are methods and exemplary compositions associated with antigen purification, exemplary aspects of which may include harvesting viral and antigenic substances from source organisms; and a purification platform comprising chemical separation and size-difference separation for the removal of contaminants, debris and impurities from the viral and protein (e.g. antigenic, including influenza hemagglutinin antigens) substances, as well as their concentration and collection.Type: ApplicationFiled: October 5, 2020Publication date: January 21, 2021Applicant: Kentucky BioProcessing, Inc.Inventors: Steven D. Hume, Leigh Burden, Joshua Morton, Greg Pogue, Barry Bratcher, Hugh A. Haydon, Carrie A. Simpson, Nick Partain, John W. Shepherd, Kelsi Swope
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Publication number: 20210000942Abstract: Disclosed herein are methods of forming compounds and exemplary compounds in the nature of a conjugated compound, which in some embodiments comprises an antigen and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for use of the conjugate mixture as a vaccine, including but not limited to use as a vaccine against various pathogens including for treatment of diseases caused by novel coronaviruses (including SARS-COV 2).Type: ApplicationFiled: July 2, 2020Publication date: January 7, 2021Applicant: Kentucky BioProcessing, Inc.Inventors: Steven D. Hume, Leigh Burden, Joshua Morton, Greg Pogue, Barry Bratcher, Hugh A. Haydon, Carrie A. Simpson, Nick Partain, Youngjun Oh, John W. Shepherd, Michael H. Pauly
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Patent number: 10822591Abstract: Disclosed herein are methods and exemplary compositions associated with virus purification, exemplary aspects of which may include harvesting viral and antigenic substances from source organisms; and a purification platform comprising chemical separation and size-difference separation for the removal of contaminants, debris and impurities from the viral and protein (e.g. antigenic, including influenza hemagglutinin antigens) substances, as well as their concentration and collection.Type: GrantFiled: June 11, 2019Date of Patent: November 3, 2020Assignee: KENTUCKY BIOPROCESSING, INC.Inventors: Leigh Burden, Steven D. Hume, Joshua Morton, Greg Pogue, Barry Bratcher, Hugh A. Haydon, Carrie A. Simpson, Nick Partain, John W. Shepherd
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Publication number: 20200113999Abstract: Disclosed herein are methods of forming compounds and exemplary compounds in the nature of a conjugated compound demonstrating enhanced stability, which in some embodiments comprises a protein and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for unrefrigerated storage for longer time periods than previous approaches, thus making feasible access to such products over a global supply chain.Type: ApplicationFiled: December 10, 2019Publication date: April 16, 2020Inventors: Leigh Burden, Steven D. Hume, Joshua Morton, Greg Pogue, Barry Bratcher, Hugh A. Haydon, Carrie A. Simpson, Nick Partain
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Publication number: 20190376049Abstract: Disclosed herein are methods and exemplary compositions associated with virus purification, antigen purification, and conjugation of virus and proteins (e.g., antigen) to form vaccines for delivery of immunological and other therapeutic agents, exemplary aspects of which may include harvesting viral and antigenic substances from source organisms; a purification platform comprising chemical separation and size-difference separation for the removal of contaminants, debris and impurities from the viral and protein (e.g. antigenic, including influenza hemagglutinin antigens) substances, as well as their concentration and collection; and a conjugation platform providing activation of the virus at a pH that increases binding rate and binding propensity between the virus and the protein, wherein embodiments related to the conjugation platform include controlling the ratio of virus to protein.Type: ApplicationFiled: June 11, 2019Publication date: December 12, 2019Inventors: Leigh Burden, Steven D. Hume, Joshua Morton, Greg Pogue, Barry Bratcher, Hugh A. Haydon, Carrie A. Simpson, Nick Partain
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Publication number: 20190374616Abstract: Disclosed herein are methods and exemplary compositions associated with virus purification, antigen purification, and conjugation of virus and proteins (e.g., antigen) to form vaccines for delivery of immunological and other therapeutic agents, exemplary aspects of which may include harvesting viral and antigenic substances from source organisms; a purification platform comprising chemical separation and size-difference separation for the removal of contaminants, debris and impurities from the viral and protein (e.g. antigenic, including influenza hemagglutinin antigens) substances, as well as their concentration and collection; and a conjugation platform providing activation of the virus at a pH that increases binding rate and binding propensity between the virus and the protein, wherein embodiments related to the conjugation platform include controlling the ratio of virus to protein.Type: ApplicationFiled: June 11, 2019Publication date: December 12, 2019Inventors: Leigh Burden, Steven D. Hume, Joshua Morton, Greg Pogue, Barry Bratcher, Hugh A. Haydon, Carrie A. Simpson, Nick Partain
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Patent number: 10214747Abstract: A new platform method to purify plant-based monoclonal antibodies is provided. Such a method includes an antibody purification platform that involves a standardized procedure for the production of a wide array of different antibodies within a simplified context. The versatility of the overall purification process accords a one-size-fits-all approach for myriad antibody products and includes plant tissue harvesting, extraction and clarification, filtrate generation, a succession of column chromatography procedures, and buffer exposure to provide the desired monoclonal antibodies in proper filtered and purified form for further incorporation and/or use within medicaments and other formulations. Thus, the purified monoclonal antibodies produced thereby such a method are also encompassed within this invention.Type: GrantFiled: October 3, 2014Date of Patent: February 26, 2019Assignee: KENTUCKY BIOPROCESSING, INC.Inventors: Josh Morton, Barry Bratcher, Kelsi Swope, Emmett Ernest Hiatt, III, Steven D. Hume, Larry Zeitlin
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Patent number: 9775376Abstract: A smokeless tobacco composition configured for insertion into the mouth of a user is provided. The smokeless tobacco composition includes a tobacco material, a sugar alcohol, and a natural gum binder component, wherein the composition is in the form of a pastille. A process for preparing a smokeless tobacco composition pastille configured for insertion into the mouth of a user is also provided. The process includes providing an aqueous mixture comprising a hydrated natural gum binder component, mixing a tobacco material with the aqueous mixture to form a smokeless tobacco mixture, heating the smokeless tobacco mixture, depositing the heated smokeless tobacco mixture into a mold, and curing the smokeless tobacco mixture to form a smokeless tobacco composition pastille.Type: GrantFiled: December 1, 2010Date of Patent: October 3, 2017Assignee: R.J. Reynolds Tobacco CompanyInventors: Daniel Verdin Cantrell, Joshua D. Morton, Steven D. Hume, Barry Bratcher, Robert Frank Boutin, Thomas Hinkemeyer, Thaddeus J. Jackson
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Publication number: 20160333365Abstract: A new platform method to purify plant-based monoclonal antibodies is provided. Such a method includes an antibody purification platform that involves a standardized procedure for the production of a wide array of different antibodies within a simplified context. The versatility of the overall purification process accords a one-size-fits-all approach for myriad antibody products and includes plant tissue harvesting, extraction and clarification, filtrate generation, a succession of column chromatography procedures, and buffer exposure to provide the desired monoclonal antibodies in proper filtered and purified form for further incorporation and/or use within medicaments and other formulations. Thus, the purified monoclonal antibodies produced thereby such a method are also encompassed within this invention.Type: ApplicationFiled: October 3, 2014Publication date: November 17, 2016Inventors: Josh Morton, Barry Bratcher, Kelsi Swope, Emmett Ernest Hiatt, III, Steven D. Hume, Larry Zeitlin
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Patent number: 9220295Abstract: A process of extracting at least one target component from a plant material is provided. The process includes homogenizing a plant material in the presence of an extraction solvent to reduce the plant material to a plant liquid component and a plant pulp component. Each of the components may be further processed to extract specific components therefrom. Specifically, the plant liquid component can be processed to extract a plant-derived starch material, plant-derived proteins, plant-derived sugars, plant-derived sugars, and the like. The plant pulp material can be processed to extract pectin and cellulose. An associated system is also provided.Type: GrantFiled: March 25, 2011Date of Patent: December 29, 2015Assignee: R.J. Reynolds Tobacco CompanyInventors: Joshua D. Morton, Steven D. Hume, Barry Bratcher
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Publication number: 20130263870Abstract: A smokeless tobacco composition configured for insertion into the mouth of a user is provided. The smokeless tobacco composition includes a tobacco material, a sugar alcohol, and a natural gum binder component, wherein the composition is in the form of a pastille. A process for preparing a smokeless tobacco composition pastille configured for insertion into the mouth of a user is also provided. The process includes providing an aqueous mixture comprising a hydrated natural gum binder component, mixing a tobacco material with the aqueous mixture to form a smokeless tobacco mixture, heating the smokeless tobacco mixture, depositing the heated smokeless tobacco mixture into a mould, and curing the smokeless tobacco mixture to form a smokeless tobacco composition pastille.Type: ApplicationFiled: May 31, 2013Publication date: October 10, 2013Inventors: Daniel Verdin Cantrell, Joshua D. Morton, Steven D. Hume, Barry Bratcher, Robert Frank Boutin, Thomas Hinkemeyer, Thaddeus J. Jackson