Abstract: The present invention provides compounds of Formula I?, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).

Abstract: A gas turbine engine includes, among other things, a propulsor section including a rotor and blades, a gear train, a compressor section and a turbine section. A static structure includes a first case and a second case. The first case includes a first engine mount location. The second case includes a second engine mount location. The first engine mount location is axially near the gear train.

Abstract: Devices, systems, and techniques are disclosed for managing electrical stimulation therapy and/or sensing of physiological signals such as brain signals. For example, a system may assist a clinician in identifying one or more electrode combinations for sensing a brain signal. In another example, a user interface may display brain signal information and values of a stimulation parameter at least partially defining electrical stimulation delivered to a patient when the brain signal information was sensed.

Abstract: An IN delivery gas-phase impermeable device for delivery between 0.2 mL and 1.0 mL of a medication solution is disclosed. The device includes an injector barrel including a plurality of slit openings disposed circumferentially along the injector barrel, a center guide positioned lengthwise within the injector barrel, a cannula in fluid communication with the medication solution fixed in position by the center guide, and a vial configured to couple with the injector barrel. The vial includes a pliable rubber stopper with multiple seal rings, each seal ring having a geometry configured to form a gas-phase impermeable seal with an internal surface of the vial. The cannula bisects the pliable rubber stopper. The device includes a base configured to reversibly engage with one or more of the slit openings of the injector barrel during actuation of the device, which may involve compression of the base toward the injector barrel.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: An automated plate shaping and verification system allows for the accurate and efficient transformation of a metal plate from a starting shape to a target shape. Using a method for path planning, the system can select heating patterns based on modeling the expected deformation of a particular material type and thickness and identifying candidate heating paths that will sufficiently cause the plate to transform towards the target shape.

Abstract: An EGR cooler may include an EGR cooler housing having top, bottom and side walls, inlet and outlet end walls disposed at opposite ends, and a longitudinal axis extending in a direction of exhaust gas flow from the inlet end to the outlet end. A plurality of cooling tubes extend through the EGR cooler between the top and bottom walls, and are arranged in a cooling tube array to form an exhaust gas receiving area at an upstream side of the cooling tube array proximate the inlet end wall so that exhaust gas flowing into the EGR cooler through an exhaust gas inlet opening will flow into the exhaust gas receiving area and then disperse through the cooling tube array. A pitch distance between the cooling tubes may be greater proximate the longitudinal axis than proximate the side walls to promote flow through, instead of around, the cooling tube array.

Abstract: According to one aspect of the present disclosure, a method of controlling an exhaust gas recirculation (EGR) system of an engine system includes determining a first EGR command according to a first method during a steady state engine condition, determining a second EGR command according to a second method during a transient engine condition, wherein the first method is based at least in part on values from a NOx sensor, and the second method is not based on values from a NOx sensor. The method further includes adjusting an EGR valve of the EGR system based on the first EGR command during the steady state engine condition, and adjusting the EGR valve based on the second EGR command during the transient engine condition.

Abstract: According to one aspect of the present disclosure, a method of controlling an exhaust gas recirculation (EGR) system of an engine system includes determining a first EGR command according to a first method during a steady state engine condition, determining a second EGR command according to a second method during a transient engine condition, wherein the first method is based at least in part on values from a NOx sensor, and the second method is not based on values from a NOx sensor. The method further includes adjusting an EGR valve of the EGR system based on the first EGR command during the steady state engine condition, and adjusting the EGR valve based on the second EGR command during the transient engine condition.

Abstract: An EGR cooler may include an EGR cooler housing having top, bottom and side walls, inlet and outlet end walls disposed at opposite ends, and a longitudinal axis extending in a direction of exhaust gas flow from the inlet end to the outlet end. A plurality of cooling tubes extend through the EGR cooler between the top and bottom walls, and are arranged in a cooling tube array to form an exhaust gas receiving area at an upstream side of the cooling tube array proximate the inlet end wall so that exhaust gas flowing into the EGR cooler through an exhaust gas inlet opening will flow into the exhaust gas receiving area and then disperse through the cooling tube array. A pitch distance between the cooling tubes may be greater proximate the longitudinal axis than proximate the side walls to promote flow through, instead of around, the cooling tube array.

Abstract: An Exhaust Gas Recirculation (EGR) system for an engine system is provided. The EGR system includes an exhaust gas treatment module positioned upstream of an EGR cooler with respect to an exhaust gas flow direction. The exhaust gas treatment module is in selective fluid communication with an exhaust gas line of an engine. The EGR system also includes a bypass line in selective fluid communication with the exhaust gas line of the engine. The EGR system further includes a valve arrangement configured to route an exhaust gas flow through at least one of the exhaust gas treatment module and the bypass line.

Abstract: An Exhaust Gas Recirculation (EGR) system for an engine system is provided. The EGR system includes an exhaust gas treatment module positioned upstream of an EGR cooler with respect to an exhaust gas flow direction. The exhaust gas treatment module is in selective fluid communication with an exhaust gas line of an engine. The EGR system also includes a bypass line in selective fluid communication with the exhaust gas line of the engine. The EGR system further includes a valve arrangement configured to route an exhaust gas flow through at least one of the exhaust gas treatment module and the bypass line.

Abstract: A method for coloring powders is provided that includes mixing a base powder and non-incorporated pigments. A colored powder composition having a base powder particle and at least a partial shell of non-incorporated pigments about the base powder particle is also provided. Articles having a coating of the colored powder composition are also provided.

Abstract: A method for coloring powders is provided that includes mixing a base powder and non-incorporated pigments. A colored powder composition having a base powder particle and at least a partial shell of non-incorporated pigments about the base powder particle is also provided. Articles having a coating of the colored powder composition are also provided.

Abstract: A method for coloring powders is provided that includes mixing a base powder and non-incorporated pigments. A colored powder composition having a base powder particle and at least a partial shell of non-incorporated pigments about the base powder particle is also provided. Articles having a coating of the colored powder composition are also provided.

Abstract: A method for coloring powders is provided that includes mixing a base powder and non-incorporated pigments. A colored powder composition having a base powder particle and at least a partial shell of non-incorporated pigments about the base powder particle is also provided. Articles having a coating of the colored powder composition are also provided.

Abstract: A technique for updating elements in a data storage facility, including a single server or a multi-server system, such as by providing updated internal code packages to the elements. The update is performed using a fixed state machine, where the elements are updated in a coordinated manner within the constraints of the state machine. In a multi-server device, code packages are distributed to elements associated with the different servers in one traversal of the state machine, during distribute states of the state machine. The distributed code packages are activated in activate states of the state machine in multiple traversals of the state machine, so there is a serial activation. The code packages can be grouped in a flexible way by configuring an external update bundle used by the state machine. The distributing of the code is based on the grouping.

Abstract: A method to update code in an information storage and retrieval system comprising one or more processors, and existing code, where that existing code includes a Concurrent Code Load having (N) phases, where that Concurrent Code Load invokes an as yet unwritten Temporal Coupling File. The method provides a code update image comprising that Temporal Coupling File. If the (i)th phase of the Concurrent Code Load invokes the Temporal Coupling File, then the method reads instructions for that (i)th phase of the Concurrent Code Load from the Temporal Coupling File, and executes those instructions. The method completes each phase of the Concurrent Code Load, and then operates the system using the code update.

Abstract: A technique for updating elements in a data storage facility, including a single server or a multi-server system, such as by providing updated internal code packages to the elements. The update is performed using a fixed state machine, where the elements are updated in a coordinated manner within the constraints of the state machine. In a multi-server device, code packages are distributed to elements associated with the different servers in one traversal of the state machine, during distribute states of the state machine. The distributed code packages are activated in activate states of the state machine in multiple traversals of the state machine, so there is a serial activation. The code packages can be grouped in a flexible way by configuring an external update bundle used by the state machine. The distributing of the code is based on the grouping.

Abstract: A technique for updating elements in a data storage facility, including a single server or a multi-server system, such as by providing updated internal code packages to the elements. The update is performed using a fixed state machine, where the elements are updated in a coordinated manner within the constraints of the state machine. In a multi-server device, code packages are distributed to elements associated with the different servers in one traversal of the state machine, during distribute states of the state machine. The distributed code packages are activated in activate states of the state machine in multiple traversals of the state machine, so there is a serial activation. The code packages can be grouped in a flexible way by configuring an external update bundle used by the state machine. The distributing of the code is based on the grouping.