Patents by Inventor Steven D. Kahl

Steven D. Kahl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunogenic ryanodine derivative and related uses
    Patent number: 5492839
    Abstract: Disclosed is a novel photo-activatable derivative of ryanodine 9-hydroxy-21-(4-azidobenzoyloxy)-9-epiryanodine. This novel ryanodine derivative has been conjugated to keyhole limpet hemocyanin (KLH) and used for the production of antibodies with high affinity and specificity to ryanodine. A radioimmunoassay specific for ryanodine was developed using the anti-ryanodine antibodies, and a dissociation constant for ryanodine of 1 nM was determined. Also disclosed is the binding of a labeled, photoactivatable derivative of ryanodine (ABRy) with the ryanodine receptor of skeletal, cardiac and brain membranes. Digestion of the labeled ryanodine receptor revealed a labeled 76 kDa tryptic fragment which is critical for the formation of the high affinity ryanodine binding site.
    Type: Grant
    Filed: January 25, 1994
    Date of Patent: February 20, 1996
    Assignee: University of Iowa Research Foundation
    Inventors: Kevin P. Campbell, Derrick R. Witcher, Peter McPherson, Steven D. Kahl, John D. Windass, Terence Lewis, Philip Bentley
  • Diagnosing malignant hyperthermia susceptibility by detection of abnormal proteolytic enzyme digestion fragments of the ryanodine receptor
    Patent number: 5462857
    Abstract: The present invention relates to a method of diagnosing malignant hyperthermia susceptibility by detecting abnormal ryanodine receptor fragments following proteolytic enzyme digestion of ryanodine receptors isolated from the sarcoplasmic reticulum of mammalian skeletal muscle. The detection of abnormal ryanodine receptor fragments is indicative of malignant hyperthermia susceptibility.
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: October 31, 1995
    Assignee: University of Iowa Research Foundation
    Inventors: Kevin P. Campbell, C. Michael Knudson, Steven D. Kahl, Charles F. Louis, James R. Mickelson
  • Purified, native dystrophin
    Patent number: 5430129
    Abstract: The invention pertains to pure, native dystrophin of mammalian skeletal muscle and a method of purifying dystrophin from mammalian skeletal muscle. The invention further pertains to a method of diagnosing muscular dystrophy by detecting the loss or abnormal structure of pure, native dystrophin from mammalian skeletal muscle. The detection of a loss of dystrophin or an abnormal structure of dystrophin is indicative of muscular dystrophy.
    Type: Grant
    Filed: January 16, 1991
    Date of Patent: July 4, 1995
    Assignee: University of Iowa Research Foundation
    Inventors: Kevin P. Campbell, Steven D. Kahl, James M. Ervasti
  • Measuring non-dystrophin proteins and diagnosing muscular dystrophy
    Patent number: 5413910
    Abstract: The invention pertains to the dystrophin-glycoprotein complex of mammalian skeletal muscle and a method of isolating said complex. The components of the complex and methods of separating and isolating said components also pertain to the invention. In addition, the invention further relates to a method of diagnosing muscular dystrophy by detecting and quantifying the loss of a non-dystrophin component of the dystrophin-glycoprotein complex with said loss being indicative of muscular dystrophy.
    Type: Grant
    Filed: October 7, 1992
    Date of Patent: May 9, 1995
    Assignee: University of Iowa Research Foundation
    Inventors: Kevin P. Campbell, James M. Ervasti, Kay Ohlendieck, Mitchell G. Gaver, Steven D. Kahl
  • Diagnosing malignant hyperthermia susceptibility by detection of abnormal proteolytic enzyme digestion fragments of the ryanodine receptor
    Patent number: 5242801
    Abstract: The present invention relates to a method of diagnosing malignant hyperthermia susceptibility by detecting abnormal ryanodine receptor fragments following proteolytic enzyme digestion of ryanodine receptors isolated from the sarcoplasmic reticulum of mammalian skeletal muscle. The detection of abnormal ryanodine receptor fragments is indicative of malignant hyperthermia susceptibility.
    Type: Grant
    Filed: August 6, 1990
    Date of Patent: September 7, 1993
    Assignees: University of Iowa Research Foundation, Regents of the University of Minnesota
    Inventors: Kevin P. Campbell, C. Michael Knudson, Steven D. Kahl, Charles F. Louis, James R. Mickelson
  • Measuring non-dystrophin proteins and diagnosing muscular dystrophy
    Patent number: 5187063
    Abstract: The invention pertains to the dystrophin-glycoprotein complex of mammalian skeletal muscle and a method of isolating said complex. The components of the complex and methods of separating and isolating said components also pertain to the invention. In addition, the invention further relates to a method of diagnosing muscular dystrophy by detecting and quantifying the loss of a non-dystrophin component of the dystrophin-glycoprotein complex with said loss being indicative of muscular dystrophy.
    Type: Grant
    Filed: May 23, 1990
    Date of Patent: February 16, 1993
    Assignee: University of Iowa Research Foundation
    Inventors: Kevin P. Campbell, James M. Ervasti, Kay Ohlendieck, Mitchell G. Gaver, Steven D. Kahl