Patents by Inventor Steven D. Knight

Steven D. Knight has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imidazoyl-benzamide anti-cancer agents
    Patent number: 7582668
    Abstract: Provided are compounds of Formula I and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: September 1, 2009
    Assignees: Cytokinetics, Incorporated, SmithKline Beecham Corporation
    Inventors: Xiangping Qian, Luke W. Ashcraft, Jianchao Wang, Bing Yao, Hong Jiang, Gustave Bergnes, Bradley P. Morgan, David J. Morgans, Jr., Dashyant Dhanak, Steven D. Knight, Nicholas D. Adams, Cynthia A. Parrish, Kevin J. Duffy, Duke Fitch, Rosanna Tedesco
  • N-(4-(imidazo[1,2A]pyridin-YL)phenethyl)benzamide inhibitors of the mitotic kinesin CENP-E for treating certain cellular proliferation diseases
    Patent number: 7504413
    Abstract: Provided herein are certain substituted N-phenethylbenzamide of formula V: that may be useful for treating certain cellular proliferation diseases and disorders by modulating the activity of CENP-E.
    Type: Grant
    Filed: November 9, 2005
    Date of Patent: March 17, 2009
    Assignees: Cytokinetics, Inc., SmithKline Beecham Corporation
    Inventors: Xiangping Qian, Gustave Bergnes, Dashyant Dhanak, Steven D. Knight, Nicholas D. Adams, Cynthia A. Parrish
  • Certain chemical entities, compositions, and methods
    Publication number: 20080255182
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
    Type: Application
    Filed: January 7, 2008
    Publication date: October 16, 2008
    Inventors: Xiangping Qian, Andrew I. McDonald, Han-Jie Zhou, Luke W. Ashcraft, Bing Yao, Hong Jiang, Jennifer Kuo Chen Huang, Jianchao Wang, David J. Morgans, Bradley P. Morgan, Gustave Bergnes, Dashyant Dhanak, Steven D. Knight, Nicholas D. Adams, Cynthia A. Parrish, Kevin Duffy, Duke Fitch, Rosanna Tedesco
  • Sulfonamides
    Patent number: 7091204
    Abstract: The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
    Type: Grant
    Filed: May 7, 2002
    Date of Patent: August 15, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: Dashyant Dhanak, Timothy F. Gallagher, Steven D. Knight
  • Sulfonamides
    Patent number: 7026349
    Abstract: The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
    Type: Grant
    Filed: May 7, 2002
    Date of Patent: April 11, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: Dashyant Dhanak, Timothy F. Gallagher, Steven D. Knight
  • Pyrrolidine sulfonamides
    Patent number: 7019008
    Abstract: A compound of Formula (I): wherein: R1 is C1-6 alkyl, benzyl, or (CH2)n—C(O)NH2; wherein the benzyl may be unsubstituted or substituted by one or two C1-6 alkyl, halogen, C1-6 alkoxy, or methylenedioxy groups; R2 is benzimidazolyl, quinolinyl, benzofuranyl, napthyl, indolyl, benzothiophenyl, phenyl, furanyl, thienyl, or pyridyl substituted or unsubstituted by one, two or three halogen, C1-3 alkyl, C1-3 alkoxy, or methylenedioxy groups; X1 and X2 are independently hydrogen, halogen, C1-3 alkyl, C1-3 alkoxy, nitro, CF3, or CN; n is 1, 2, or 3; m is 1, 2 or 3; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: March 28, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: Dashyant Dhanak, Steven D. Knight, Jian Jin, Ralph A. Rivero, Anthony Sapienza
  • Sulfonamides
    Patent number: 6849635
    Abstract: The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
    Type: Grant
    Filed: May 7, 2002
    Date of Patent: February 1, 2005
    Assignee: SmithKline Beecham Corporation
    Inventors: Dashyant Dhanak, Timothy F. Gallagher, Steven D. Knight, Stanley J. Schmidt
  • Urotensin-II receptor antagonists
    Patent number: 6818655
    Abstract: The present invention relates to quinolines, pharmaceutical compositions containing them and their use as antagonists of urotensin II.
    Type: Grant
    Filed: July 25, 2003
    Date of Patent: November 16, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Dashyant Dhanak, Steven D. Knight, Gregory L. Warren
  • Sulfonamides
    Publication number: 20040198979
    Abstract: The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
    Type: Application
    Filed: November 7, 2003
    Publication date: October 7, 2004
    Inventors: Dashyant Dhanak, Timothy F. Gallagher, Steven D. Knight
  • Sulfonamides
    Publication number: 20040152893
    Abstract: The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
    Type: Application
    Filed: November 7, 2003
    Publication date: August 5, 2004
    Inventors: Dashyant Dhanak, Timothy F. Gallagher, Steven D Knight, Stanley J. Schmidt
  • Sulfonamides
    Publication number: 20040152891
    Abstract: The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
    Type: Application
    Filed: November 7, 2003
    Publication date: August 5, 2004
    Inventors: Dashyant Dhanak, Timothy F. Gallagher, Steven D. Knight
  • Pyrrolidine sulfonamides
    Publication number: 20040152692
    Abstract: The present invention relates to pyrrolidine sulfonamides, pharmaceutical compositions containing them and their use as urotensin II antagonists.
    Type: Application
    Filed: September 26, 2003
    Publication date: August 5, 2004
    Inventors: Dashyant Dhanak, Steven D Knight, Jian Jin, Ralph A Rivero
  • Sulfonamides
    Publication number: 20040152895
    Abstract: The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
    Type: Application
    Filed: November 7, 2003
    Publication date: August 5, 2004
    Inventors: Dashyant Dhanak, Timothy F Gallagher, Steven D Knight, Stanley J Schmidt
  • Sulfonamides
    Publication number: 20040152906
    Abstract: The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
    Type: Application
    Filed: November 7, 2003
    Publication date: August 5, 2004
    Inventors: Dashyant Dhanak, Timothy F. Gallagher, Steven D. Knight
  • Sulfonamides
    Publication number: 20040142948
    Abstract: The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
    Type: Application
    Filed: November 7, 2003
    Publication date: July 22, 2004
    Inventors: Dashyant Dhanak, Timothy F. Gallagher, Steven D. Knight
  • Pyrrolidine sulfonamides
    Publication number: 20040142923
    Abstract: The present invention relates to pyrrolidine sulfonamides, pharmaceutical compositions containing them and their use as urotensin II antagonists.
    Type: Application
    Filed: September 26, 2003
    Publication date: July 22, 2004
    Inventors: Dashyant Dhanak, Steven D. Knight, Jian Jin, Ralph A. Rivero
  • Pyrrolidine sulfonamides
    Publication number: 20040138224
    Abstract: The present invention relates to pyrrolidine sulfonamides, pharmaceutical compositions containing them and their use as urotensin II antagonists.
    Type: Application
    Filed: September 26, 2003
    Publication date: July 15, 2004
    Inventors: Dashyant Dhanak, Steven D Knight, Jian Jin, Ralph A Rivero, Anthony Sapienza
  • Pyrrolidine sulfonamides
    Publication number: 20040082566
    Abstract: The present invention relates to pyrrolidine sulfonamides, pharmaceutical compositions containing them and their use as urotensin II antagonists.
    Type: Application
    Filed: September 26, 2003
    Publication date: April 29, 2004
    Inventors: Dashyant Dhanak, Steven D Knight, Jian Jin, Ralph A Rivera, Anthony Sapienza
  • Urotensin-ll receptor antagonists
    Publication number: 20040063757
    Abstract: The present invention relates to quinolines, pharmaceutical compositions containing them and their use as antagonists of urotensin II.
    Type: Application
    Filed: July 25, 2003
    Publication date: April 1, 2004
    Inventors: Dashyant Dhanak, Steven D. Knight, Gregory L. Warren
  • Urotensin-II receptor antagonists
    Publication number: 20040053963
    Abstract: The present invention relates to novel quinolones and their use as urotensin antagonists.
    Type: Application
    Filed: June 11, 2003
    Publication date: March 18, 2004
    Inventors: Dashyant Dhanak, Steven D. Knight