Patents by Inventor Steven D. Marlin
Steven D. Marlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090035321Abstract: The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.Type: ApplicationFiled: December 4, 2006Publication date: February 5, 2009Inventors: Timothy A. Springer, Robert Rothlein, Steven D. Marlin, Michael L. Dustin
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Patent number: 7354588Abstract: The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.Type: GrantFiled: June 7, 1995Date of Patent: April 8, 2008Assignee: Dana Farber Cancer InstituteInventors: Timothy A. Springer, Robert Rothlein, Steven D. Marlin, Michael L. Dustin
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Publication number: 20040039186Abstract: This invention relates to the therapeutic induction of supra-normal apoptosis in activated inflammatory cells, or cells at a site of inflammation, by introducing into those cells a chimeric gene containing an apoptosis-inducing gene (AIG) driven by a promoter of an inducible gene activated in inflammation and a promoter enhancer such that the inflammatory cells are targeted. In one embodiment, the chimeric gene comprises at least one TNF&agr; promoter enhancer attached to a functional copy of a minimal TNF&agr; promoter and further attached to at least one copy of an apoptosis-inducing gene, wherein expression of the gene is driven by the TNF&agr; promoter. Examples of apoptosis-inducing genes include caspase-3, caspase-4, caspase-5, and Granzyme B. Advantageously, the TNFp-AIG chimeric gene is expressed in only those cells producing the inflammatory cytokine, TNF&agr;.Type: ApplicationFiled: January 31, 2003Publication date: February 26, 2004Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Revati J. Tatake, Steven D. Marlin, Randall W. Barton
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Patent number: 6537784Abstract: This invention relates to chimeric nucleic acids and to the therapeutic induction of apoptosis in activated inflammatory cells, or cells at a site of inflammation, by introducing into those cells the chimeric nucleic acid. The chimeric nucleic acid having at least one TNF&agr; promoter enhancer attached to a functional copy of a TNF&agr; promoter and further attached to at least one copy of an apoptosis-inducing gene, which is further attached to a 3′UTR. The apoptosis-inducing gene is Granzyme B. The invention also relates to methods of making and using self-regulated apoptosis chimeric nucleic acids and pharmaceutical compositions containing them for treating inflammatory diseases.Type: GrantFiled: January 12, 1999Date of Patent: March 25, 2003Assignee: Boehringer Ingelheim Pharmaceuticals Inc.Inventors: Revati J. Tatake, Steven D. Marlin, Randall W. Barton
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Patent number: 6525184Abstract: This invention relates to the therapeutic induction of apoptosis in activated inflammatory cells, or cells at a site of inflammation, by introducing into those cells a chimeric gene containing an apoptosis-inducing gene (AIG) driven by a promoter of an inducible gene activated in inflammation and a promoter enhancer such that the inflammatory cells are targeted. In one embodiment, the chimeric gene comprises at least one TNF&agr; promoter enhancer attached to a functional copy of a minimal TNF&agr; promoter and further attached to at least one copy of an apoptosis-inducing gene, wherein expression of the gene is driven by the TNF&agr; promoter. Attachment can be direct, distal, proximal or combinations thereof. Example apoptosis-inducing genes include caspase 3, caspase 4, caspase 5, Granzyme B. Advantageously, the TNFp-AIG chimeric gene is expressed in only those cells producing the inflammatory cytokine, TNF&agr;.Type: GrantFiled: February 27, 1998Date of Patent: February 25, 2003Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Revati J. Tatake, Steven D. Marlin, Randall W. Barton
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Patent number: 6358510Abstract: The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.Type: GrantFiled: June 7, 1995Date of Patent: March 19, 2002Assignee: Dana Farber Cancer InstituteInventors: Timothy A. Springer, Michael L. Dustin, Robert Rothlein, Steven D. Marlin
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Patent number: 5831036Abstract: The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.Type: GrantFiled: October 25, 1993Date of Patent: November 3, 1998Assignee: Dana Farber Cancer InstituteInventors: Timothy A. Springer, Robert Rothlein, Steven D. Marlin, Michael L. Dustin
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Patent number: 5612216Abstract: The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.Type: GrantFiled: January 25, 1994Date of Patent: March 18, 1997Assignee: Dana Farber Cancer InstituteInventors: Timothy A. Springer, Robert Rothlein, Steven D. Marlin, Michael L. Dustin
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Patent number: 5475091Abstract: The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.Type: GrantFiled: January 25, 1994Date of Patent: December 12, 1995Assignee: The Dana Farber Cancer InstituteInventors: Timothy A. Springer, Robert Rothlein, Steven D. Marlin, Michael L. Dustin
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Patent number: 5472849Abstract: A method for the detection of the presence of inflammation in a patient by measuring the amount of circulating intercellular adhesion molecule (cICAM-1) in a sample of one or more bodily fluids of the patient and then comparing the amount of cICAM-1 in the sample to standards normal for the bodily fluid or fluids assayed. The amount of cICAM-1 can be measured using anti-ICAM-1 antibodies. Higher than normal amounts of cICAM-1 indicate the presence of inflammation.Type: GrantFiled: November 24, 1993Date of Patent: December 5, 1995Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Robert Rothlein, Steven D. Marlin
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Patent number: 5354659Abstract: A method for the detection of the presence of inflammation in a patient by measuring the amount of circulating intercellular adhesion molecule (cICAM-1) in a sample of one or more bodily fluids of the patient and then comparing the amount of cICAM-1 in the sample to standards normal for the bodily fluid or fluids assayed. The amount of cICAM-1 can be measured using anti-ICAM-1 antibodies. Higher than normal amounts of cICAM-1 indicate the presence of inflammation.Type: GrantFiled: October 21, 1992Date of Patent: October 11, 1994Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Robert Rothlein, Steven D. Marlin
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Patent number: 5284931Abstract: Pharmaceutical compositions comprising antibodies to intercellular adhesion molecule-1 (ICAM-1 or CD54) are useful in methods of decreasing the severity of inflammation associated with the adhesion of leukocytes to cells bearing ICAM-1. Treatment with anti-ICAM-1 antibodies reduced the severity of inflammation associated with acute organ or tissue rejection and prolonged allograft survival time. Such compositions may optionally contain other immunsuppressive agents.Type: GrantFiled: April 27, 1990Date of Patent: February 8, 1994Assignee: Dana Farber Cancer InstituteInventors: Timothy A. Springer, Robert Rothlein, Steven D. Marlin, Michael L. Dustin
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Patent number: 5223396Abstract: A method for the detection of the presence of inflammation in a patient by measuring the amount of circulating intercellular adhesion molecule (cICAM-1) in a sample of one or more bodily fluids of the patient and then comparing the amount of cICAM-1 in the sample to standards normal for the bodily fluid or fluids assayed. The amount of cICAM-1 can be measured using anti-ICAM-1 antibodies. Higher than normal amounts of cICAM-1 indicate the presence of inflammation. Also contemplated is a method for the detection of organ transplant or tissue graft rejection.Type: GrantFiled: May 3, 1991Date of Patent: June 29, 1993Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Robert Rothlein, Steven D. Marlin