Abstract: Disclosed herein are compounds that inhibit the 3C-like protease of SARS-CoV-2. Also disclosed herein are pharmaceutical compositions comprising the compounds, and methods of using the compounds, e.g., in a method of treating a viral infection, such as a coronavirus infection.

Abstract: Disclosed herein are compounds that inhibit 3C-like protease and inhibit replication of viruses, including SARS-CoV-2. Also disclosed herein are pharmaceutical compositions comprising the compounds, and methods of using the compounds, e.g., in a method of treating a viral infection, such as a coronavirus infection.

Abstract: A brush seal system includes a component including a first mating surface. The brush seal system further includes a brush seal including a brush seal backing plate, a retaining ring, and a plurality of bristles retained between the brush seal backing plate and the retaining ring. The brush seal backing plate includes a second mating surface mounted to the first mating surface. The brush seal system further includes at least one cooling channel extending from an exterior side of the component to an interior side of the component so as to bypass the brush seal.

Abstract: An aerodynamic component of a gas turbine engine is provided and is fittable to a shell having a shell shape. The aerodynamic component includes a body having a component shape initially deviating from the shell shape prior to an assembly operation in which the aerodynamic component is to be fit to the shell. Deviation of the component shape from the shell shape aids in an establishment of a final desired shape of the aerodynamic component following the assembly operation.

Abstract: A brush seal system includes a component including a first mating surface. The brush seal system further includes a brush seal including a brush seal backing plate, a retaining ring, and a plurality of bristles retained between the brush seal backing plate and the retaining ring. The brush seal backing plate includes a second mating surface mounted to the first mating surface. The brush seal system further includes at least one cooling channel extending from an exterior side of the component to an interior side of the component so as to bypass the brush seal.

Abstract: A heat shield panel for use in a gas turbine engine combustor is disclosed. In various embodiments, the heat shield panel includes a hot side, a cold side spaced from the hot side, a rail member disposed on the cold side proximate an outer perimeter, the rail member having an outer wall and an inner wall and an orifice extending through the rail member, from the inner wall to the outer wall, the orifice having an entrance portion having an entrance opening positioned on the inner wall and extending at least to an intermediate portion of the rail member and an exit portion having an exit opening positioned on the outer wall and extending at least to the intermediate portion of the rail member, the entrance portion of the orifice being angled relative to the exit portion of the orifice.

Abstract: A brush seal system includes a component including a first mating surface. The brush seal system further includes a brush seal including a brush seal backing plate, a retaining ring, and a plurality of bristles retained between the brush seal backing plate and the retaining ring. The brush seal backing plate includes a second mating surface mounted to the first mating surface. The brush seal system further includes at least one cooling channel extending from an exterior side of the component to an interior side of the component so as to bypass the brush seal.

Abstract: A heat shield panel for use in a gas turbine engine combustor is disclosed. In various embodiments, the heat shield panel includes a hot side, a cold side spaced from the hot side, a rail member disposed on the cold side proximate an outer perimeter, the rail member having an outer wall and an inner wall and an orifice extending through the rail member, from the inner wall to the outer wall, the orifice having an entrance portion having an entrance opening positioned on the inner wall and extending at least to an intermediate portion of the rail member and an exit portion having an exit opening positioned on the outer wall and extending at least to the intermediate portion of the rail member, the entrance portion of the orifice being angled relative to the exit portion of the orifice.

Abstract: A heat shield panel for use in a gas turbine engine combustor is disclosed. In various embodiments, the heat shield panel includes a hot side, a cold side spaced from the hot side, a rail member disposed on the cold side proximate an outer perimeter, the rail member having an outer wall and an inner wall and an orifice extending through the rail member, from the inner wall to the outer wall, the orifice having an entrance portion having an entrance opening positioned on the inner wall and extending at least to an intermediate portion of the rail member and an exit portion having an exit opening positioned on the outer wall and extending at least to the intermediate portion of the rail member, the entrance portion of the orifice being angled relative to the exit portion of the orifice.

Abstract: An aerodynamic component of a gas turbine engine is provided and is fittable to a shell having a shell shape. The aerodynamic component includes a body having a component shape initially deviating from the shell shape prior to an assembly operation in which the aerodynamic component is to be fit to the shell. Deviation of the component shape from the shell shape aids in an establishment of a final desired shape of the aerodynamic component following the assembly operation.

Abstract: A heat shield panel for a gas turbine engine combustor is disclosed. The heat shield panel includes a hot side defining a first surface having an outer perimeter, a cold side defining a second surface spaced from the first surface and a plurality of holes, each hole including a central axis having vector components defined by a common vector.

Abstract: A multi-ring spacer includes a first ring having a first clocking position, a second ring coaxial with the first ring, and having a second clocking position. A total kink angle of the multi ring spacer is dependent on an angular deviation of the second ring's clocking position relative to the first ring's clocking position.

Abstract: A heat shield panel for use in a gas turbine engine combustor is disclosed. In various embodiments, the heat shield panel includes a hot side, a cold side spaced from the hot side, a rail member disposed on the cold side proximate an outer perimeter, the rail member having an outer wall and an inner wall and an orifice extending through the rail member, from the inner wall to the outer wall, the orifice having an entrance portion having an entrance opening positioned on the inner wall and extending at least to an intermediate portion of the rail member and an exit portion having an exit opening positioned on the outer wall and extending at least to the intermediate portion of the rail member, the entrance portion of the orifice being angled relative to the exit portion of the orifice.

Abstract: A vane has an airfoil extending between a radially outer platform and a radially inner platform. At least one of the platforms has nominally radially thinner portions, and a pad defining a radially thicker portion. The pad has a radial thickness that is greater than a thickness of the nominal radially thinner portions. The pad surrounds an outer periphery of the airfoil on a side of the radially outer platform. The pad has a varying radial thickness. A mid-turbine frame and a gas turbine engine are also disclosed.

Abstract: A brush seal system includes a component including a first mating surface. The brush seal system further includes a brush seal including a brush seal backing plate, a retaining ring, and a plurality of bristles retained between the brush seal backing plate and the retaining ring. The brush seal backing plate includes a second mating surface mounted to the first mating surface. The brush seal system further includes at least one cooling channel extending from an exterior side of the component to an interior side of the component so as to bypass the brush seal.

Abstract: A heat shield panel for a combustor of a gas turbine engine including a panel body having a first surface and a second surface. The second surface being configured to be oriented toward a combustor liner of the combustor. The heat shield further includes a plurality of first pin fins projecting from the second surface of the panel body. Each of the plurality of first pin fins has a rounded top opposite the second surface. The heat shield further includes a plurality of second pin fins projecting from the second surface of the panel body. Each of the plurality of second pin fins has a flat top opposite the second surface. The plurality of second pin fins are intermittently spaced amongst the plurality of first pin fins. The plurality of second pin fins are organized in a uniform distribution across the second surface of the heat shield panel.

Abstract: A gas turbine engine includes a turbine section including a first vane stage. The gas turbine engine further includes a combustor disposed forward of the first vane stage. The combustor includes a combustion chamber in fluid communication with the first vane stage. The combustion chamber is radially defined between a first shell and a second shell. The first shell includes a first seal assembly at an aft end of the first shell. The first seal assembly includes a conformal seal forming a first seal between the first shell and a forward face of the first vane stage. The second shell includes a second seal assembly at an aft end of the second shell. The second seal assembly includes a brush seal forming a second seal between the second shell and the forward face of the first vane stage.

Abstract: A combustor for use in a gas turbine engine, the combustor enclosing a combustion chamber having a combustion area. The combustor includes: a shell having a kink; and a kinked heat shield panel in facing spaced relationship with the shell, the kinked heat shield panel including a kink located proximate the kink in the shell, wherein the kinked heat shield panel further includes a first surface, a second surface opposite the first surface, and a mounting stud located proximate the kink of the kinked heat shield panel and extending away from the second surface.

Abstract: A gas turbine engine includes a combustor. A turbine section is in fluid communication with the combustor. The turbine section includes a first vane stage aft of the combustor. A plurality of vane cooling passages extending through a forward flange of the first vane stage to the radial inner surface for communicating cooling airflow into the core flow path forward of the leading edge. A seal assembly is disposed between the combustor and the forward flange of the vane stage. The seal includes a plurality of circumferentially spaced apart slots and a plurality of seal cooling passages that extend from the radially outer surface to the radially inner surface at each of the plurality of circumferentially spaced apart slots.

Abstract: A heat shield panel for use in a gas turbine engine combustor is disclosed. In various embodiments, the heat shield panel includes a hot side, a cold side spaced from the hot side, and a rail disposed about a periphery of the cold side, the rail including a first rail member having a first length extending along the panel, a first height extending from the cold side, and a first thickness that varies along the first length.