Abstract: The present invention relates to Ras inhibitors, intermediates in the synthesis thereto, and methods for preparing the Ras inhibitors and the intermediates.

Abstract: A portable hydration device for use with a portable hydration system is described. The portable hydration device comprises a housing having an inlet, configured to be in fluid communication with a reservoir of water, and an outlet configured to be in fluid communication with a mouthpiece; the housing defining a throughbore connecting the inlet and the outlet. The device also includes a receptacle configured to contain an additive and a selector. The selector is movable between an engaged position in which the selector is engaged with the receptacle and a disengaged position in which the selector is disengaged from the receptacle. In the engaged position the selector permits fluid communication between the receptacle and the throughbore and in the disengaged position the selector prevents fluid communication between the receptacle and the throughbore. The selector defines a throughbore, the selector throughbore being aligned with the housing throughbore in the engaged and the disengaged positions.

Abstract: A general-purpose air sterilizing system destroys activation of air-borne pathogens, designed with different embodiments. The methods used to build the apparatus allows destroying airborne pathogens like bacteria, mold, mildew, allergens and deactivates viruses such as SARS CoV-2. The apparatus supports air circulation system that contains filter which comprising array of Ultraviolet (UV) Light Emitting Diode (LEDs) of 262-nm wavelength, AKA UVC, are used.

Abstract: A general-purpose air sterilizing system destroys activation of air-borne pathogens, designed with different embodiments. The methods used to build the apparatus allows destroying airborne pathogens like bacteria, mold, mildew, allergens and deactivates viruses such as SARS CoV-2. The apparatus supports air circulation system that contains filter which comprising array of Ultraviolet (UV) Light Emitting Diode (LEDs) of 262-nm wavelength, AKA UVC, are used.

Abstract: A portable hydration device for use with a portable hydration system is described. The portable hydration device comprises a housing having an inlet, configured to be in fluid communication with a reservoir of water, and an outlet configured to be in fluid communication with a mouthpiece; the housing defining a throughbore connecting the inlet and the outlet. The device also includes a receptacle configured to contain an additive and a selector. The selector is movable between an engaged position in which the selector is engaged with the receptacle and a disengaged position in which the selector is disengaged from the receptacle. In the engaged position the selector permits fluid communication between the receptacle and the throughbore and in the disengaged position the selector prevents fluid communication between the receptacle and the throughbore. The selector defines a throughbore, the selector throughbore being aligned with the housing throughbore in the engaged and the disengaged positions.

Abstract: A method of preparing a thin film, the method comprising: (a) mixing a lipid, emulsifier, and solvent to provide a uniform first mixture; (b) contacting an active ingredient with the uniform first mixture to provide a thickened second mixture; (c) contacting a binder with the thickened second mixture to provide a slurry; and (d) hot extruding, casting, and condensing the slurry to provide the thin film; or cooling, shearing, mixing, casting, and condensing the slurry to provide the thin film.

Abstract: A medicant composition is provided. The composition includes a film layer and a powder matrix layer. The powder matrix layer includes a medicant. The powder matrix layer is applied to the film layer by admixing particulate to form a powder matrix and by then applying the powder matrix to the film layer by any desired method. The composition of the powder matrix is varied to alter the dissolution rate of the medicant, the adhesion of the medicant composition, and other physical properties of the powder matrix. The powder matrix layer can be cured.

Abstract: In one aspect, a method includes receiving a data packet at a routing node that includes a processor. The method also includes determining at least one value for the data packet, selecting a routing table from a plurality of routing tables stored at the routing node in response to the at least one value for the packet and forwarding the data packet in response to the routing table selected. Each routing table is associated with a respective one cost function.

Abstract: A medicant composition is provided. The composition includes a film layer and a powder matrix layer. The powder matrix layer includes a medicant. The powder matrix layer is applied to the film layer by admixing particulate to form a powder matrix and by then applying the powder matrix to the film layer by any desired method. The composition of the powder matrix is varied to alter the dissolution rate of the medicant, the adhesion of the medicant composition, and other physical properties of the powder matrix. The powder matrix layer can be cured.

Abstract: A crossing device aids in crossing from a near side to a far side of an obstacle. It comprises a lead assembly that is projected to the far side of the obstacle and that includes an anchor assembly and a pulley. The anchor assembly has a base, a launch tube that is secured to the base, a spike that is housed within the launch tube, and a propellant charge. The anchor assembly is anchored on the far side of the obstacle by remotely initiating the propellant charge. The explosion force drives the spike through the launch tube and the base, into a landing surface. A bridge is connected to the pulley and is pulled to span across the obstacle. The bridge, lead assembly, and anchor may be collected on the far side for additional uses.

Abstract: A medicament composition for the administration to pets is provided. The composition generally includes a film, a medicament and a flavoring composition that renders the film palatable to a pet.

Abstract: In one aspect, a method includes receiving, at a first node in a network, a resource reservation request from a second node in the network, determining, at the first node, if there is another node in the network that can be used to reach a destination and meet the resource reservation request and notifying the second node a result of the determining.

Abstract: In one aspect, a method includes receiving, at a first node in a network, a resource reservation request from a second node in the network, determining, at the first node, if there is another node in the network that can be used to reach a destination and meet the resource reservation request and notifying the second node a result of the determining.

Abstract: A multi-level power converter system includes a multi-level power converter configured to synthesize at least three direct current (DC) voltages into an alternating current (AC) output voltage, and includes a plurality of transistors. A controller generates pulse-width modulation (PWM) signals used to control a state of the plurality of transistors of the multi-level converter by comparing first and second carrier signals to a reference signals, wherein a period of the first and second carrier signals is randomly varied from a nominal period.

Abstract: Methods for modulating dissolution, bioavailability, bioequivalence and drug delivery profile of thin film drug delivery systems, controlled-release thin film dosage formats, and methods for their manufacture and use are disclosed.

Abstract: A medicant composition is provided. The composition includes a film layer and a powder matrix layer. The powder matrix layer includes a medicant. The powder matrix layer is applied to the film layer by admixing particulate to form a powder matrix and by then applying the powder matrix to the film layer by any desired method. The composition of the powder matrix is varied to alter the dissolution rate of the medicant, the adhesion of the medicant composition, and other physical properties of the powder matrix. The powder matrix layer can be cured.

Abstract: A medicant composition is provided. The composition includes a film layer and a powder matrix layer. The powder matrix layer includes a medicant. The powder matrix layer is applied to the film layer by admixing particulate to form a powder matrix and by then applying the powder matrix to the film layer by any desired method. The composition of the powder matrix is varied to alter the dissolution rate of the medicant, the adhesion of the medicant composition, and other physical properties of the powder matrix. The powder matrix layer can be cured.

Abstract: A method of preparing a thin film, the method comprising: (a) mixing a lipid, emulsifier, and solvent to provide a uniform first mixture; (b) contacting an active ingredient with the uniform first mixture to provide a thickened second mixture; (c) contacting a binder with the thickened second mixture to provide a slurry; and (d) hot extruding, casting, and condensing the slurry to provide the thin film; or cooling, shearing, mixing, casting, and condensing the slurry to provide the thin film.

Abstract: A method of preparing a thin film, the method comprising: (a) mixing a lipid, emulsifier, and solvent to provide a uniform first mixture; (b) contacting an active ingredient with the uniform first mixture to provide a thickened second mixture; (c) contacting a binder with the thickened second mixture to provide a slurry; and (d) hot extruding, casting, and condensing the slurry to provide the thin film; or cooling, shearing, mixing, casting, and condensing the slurry to provide the thin film.